Aromatic aminomethane compounds, as well as preparation and medical use thereof

Abstract

The invention relates to the field of pharmacochemistry, in particular to aroma-like methylamine-type compounds (I), wherein the definitions of Ar, X, L and R are the same as those in the Description. Pharmacological tests testifies that the aroma-like methylamine-type compounds can be used for curing a series of diseases caused by the abnormality of potassium channel function, such as the diseases of arrhythmia, ischemic injury and the like. The invention also discloses a preparation method of the compounds.

Description

technical field The invention relates to the field of medicinal chemistry, in particular to a class of arylmethylamine compounds, a preparation method thereof, a pharmaceutical preparation thereof and a medical application thereof. Background technique Arrhythmia is a major disease that seriously threatens people's health and quality of life. According to incomplete statistics, about millions of people die suddenly every year due to failure to effectively control primary or secondary arrhythmia, and the patients are getting younger. Therefore, the market size of antiarrhythmic drugs is increasing. expanding year by year. Antiarrhythmic drugs can be divided into four categories according to different mechanisms of action. Currently, Class III antiarrhythmic drugs—potassium ion channel blockers are mainly used in clinical applications, including dofetilide, sotalol, etc. The mechanism of action of the drug is to specifically block the fast delayed rectifier potassium channe...

AI Technical Summary

Problems solved by technology

On the other hand, traditional arrhythmia drugs are mostly aimed at ventricular arrhythmias that have begun to deteriorate, and block the rapidly activated delayed rectifier potassium channel (I Kr ) or sodium and calcium channels, ignoring the control of atrial arrhythmia symptoms in the early stage of arrhythmia disease and the prevention of atrial arrhythmia from worsening to ventricular arrhythmia, in view of the above problems, the ultra-fast delayed rectifier potassium channel (I Kur ) is a very promising target for the treatment of atrial arrhythmias and adjuvant therapy for ventricular arrhythmias due to its selective presence in the atrium

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