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Analgesic anti-inflammatory composite medicament and method for preparing same

The technology of a composition and medicine, applied in the field of the composition and preparation of corygnatein and tetrahydropalmatine, can solve the problems of poor effect on pain, etc., and achieve the effect of convenient administration, remarkable effect and stable blood drug concentration

Active Publication Date: 2011-01-12
GANSU CHEEZHENG TIBETAN MEDICINE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The analgesic effect of tetrahydropalmatine is weaker than that of pethidine, but stronger than that of general antipyretic and analgesic drugs. It has a better effect on chronic persistent pain and less effect on trauma and postoperative pain.
In addition to the analgesic effect, there are obvious sedative and hypnotic effects

Method used

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  • Analgesic anti-inflammatory composite medicament and method for preparing same
  • Analgesic anti-inflammatory composite medicament and method for preparing same
  • Analgesic anti-inflammatory composite medicament and method for preparing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0229] Example 1: Composition transdermal patch of uricine and tetrahydropalmatine

[0230] Gao Ujiasu: 1.5kg Tetrahydropalmatine: 1.5kg

[0231] lauryl nitrogen Ketone: 1kg Acrylic pressure sensitive adhesive: 7kg;

[0232] Take 1.5kg of corygine and 1.5kg of tetrahydropalmatine, add 7kg of acrylic pressure-sensitive adhesive and lauryl nitrogen Ketone 1kg, dissolved and mixed, was prepared into a solution; using the salivation process, the above solution was coated on the backing layer, evaporated to dryness of the solvent, and covered with a protective layer after cooling to obtain a transparent composition of urcin and tetrahydropalmatine. skin patch.

Embodiment 2

[0233] Example 2: Composition transdermal patch of gluconate and tetrahydropalmatine

[0234] Gao Ujiasu: 0.2kg Tetrahydropalmatine: 1.8kg

[0235] Menthol: 0.2kg Polyisobutylene pressure-sensitive adhesive: 9kg;

[0236] Take 0.2kg of quinine and 1.8kg of tetrahydropalmatine, add 9kg of polyisobutylene pressure-sensitive adhesive and 0.2kg of menthol, dissolve and mix, and prepare a solution; adopt the salivation process to coat the above solution on the backing layer, After the solvent is evaporated to dryness, after cooling, a protective layer is covered to obtain a transdermal patch of the combination of corygine and tetrahydropalmatine.

Embodiment 3

[0237] Example 3: Composition transdermal patch of gluconate and tetrahydropalmatine

[0238] Gao Ujiasu: 1.8kg Tetrahydropalmatine: 0.5kg

[0239] Propylene glycol: 1.8kg Polysiloxane pressure-sensitive adhesive: 4kg;

[0240] Take 1.8kg of quinine and 0.5kg of tetrahydropalmatine, add 4kg of polysiloxane pressure-sensitive adhesive and 1.8kg of propylene glycol, dissolve and mix, and prepare a solution; adopt the salivation process to coat the above solution on the backing layer , until the solvent is evaporated to dryness, and then covered with a protective layer after cooling to obtain a transdermal patch of the combination of goujingin and tetrahydropalmatine.

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Abstract

The invention discloses an analgesic anti-inflammatory composite medicament made from lappaconitine and tetrahydropalmatine, a patch made from the composite medicament and a method for preparing the pThe invention discloses an analgesic anti-inflammatory composite medicament made from lappaconitine and tetrahydropalmatine, a patch made from the composite medicament and a method for preparing the pastrointestinal tracts are avoided, the toxicity and the side effect of the composite medicament are reduced, and the bioavailability and the safe curative effect of the composite medicament are imo gastrointestinal tracts are avoided, the toxicity and the side effect of the composite medicament are reduced, and the bioavailability and the safe curative effect of the composite medicament are improved. The composite medicament is convenient to use without causing patients to be afflicted by pain and is very effective in relieving pain and diminishing inflammation.proved. The composite medicament is convenient to use without causing patients to be afflicted by pain and is very effective in relieving pain and diminishing inflammation.atch. The patch comprises a back lining layer, a medicament storage layer and a protection layer, wherein the medicament storage layer is made from raw materials including the lappaconitine, the tetraatch. The patch comprises a back lining layer, a medicament storage layer and a protection layer, wherein the medicament storage layer is made from raw materials including the lappaconitine, the tetrahydropalmatine and pressure-sensitive adhesive; and the patch is made by adding a proper amount of transdermal enhancerfrom in to the same three raw materials. Experiments and clinical research provehydropalmatine and pressure-sensitive adhesive; and the patch is made by adding a proper amount of transdermal enhancerfrom in to the same three raw materials. Experiments and clinical research provethat the composite medicament made from raw medicament materials of lappaconitine and tetrahydropalmatine according to a certain proportion can reduce the toxicity of the lappaconitine and improve thethat the composite medicament made from raw medicament materials of lappaconitine and tetrahydropalmatine according to a certain proportion can reduce the toxicity of the lappaconitine and improve the median lethal dose (LD 50). Due to the use of the patch made from the composite medicament, the blood concentration can be kept stable for a long time, the first-pass effect on liver and the damage tmedian lethal dose (LD 50). Due to the use of the patch made from the composite medicament, the blood concentration can be kept stable for a long time, the first-pass effect on liver and the damage to g

Description

technical field [0001] The invention relates to a pharmaceutical composition and a preparation method thereof, in particular to an anti-inflammation and analgesic composition of corygine and tetrahydropalmatine and a preparation method thereof. Background technique [0002] Pain is the most common multiple co-symptom in clinical diseases of medical research, and this conundrum is a great challenge for researchers and doctors. Nowadays, the drugs for pain treatment are mainly Western medicines, which are mainly divided into two types: non-steroidal anti-inflammatory analgesics and narcotic analgesics. Among these two types of drugs, although anesthetic drugs have strong analgesic effects, they have large side effects ( Addiction), although non-steroidal anti-inflammatory analgesics do not have such a large side effect of narcotic analgesics, but there are many negative adverse reactions such as gastrointestinal tract. The medical field is also constantly seeking anti-inflamm...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/439A61K31/4375A61K9/70A61P29/00A61J3/00
Inventor 刘海龙黄玉兰高虹
Owner GANSU CHEEZHENG TIBETAN MEDICINE CO LTD
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