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Methods for treating cancer comprising the administration of a vitamin d compound and an additional therapeutic agent

A technology for therapeutic agents, vitamins, applied in the field of glucocorticoids

Inactive Publication Date: 2009-09-09
库伽尔生物科技公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, the main limitation of using vitamin D as a therapeutic agent is its tendency to cause hypercalcemia

Method used

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  • Methods for treating cancer comprising the administration of a vitamin d compound and an additional therapeutic agent
  • Methods for treating cancer comprising the administration of a vitamin d compound and an additional therapeutic agent
  • Methods for treating cancer comprising the administration of a vitamin d compound and an additional therapeutic agent

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Embodiment Construction

[0039] The methods of treating cancer described herein comprise administering to a mammal, preferably a human, a vitamin D compound, such as ceocalcitol, and at least one therapeutic agent, such as an anticancer agent or a steroid, especially a corticosteroid or a glucocorticoid. The compositions described herein comprise a vitamin D compound and at least one additional therapeutic agent, such as an anticancer agent or a steroid, especially a glucocorticoid. Other anticancer therapies, such as administration of another anticancer agent, radiation therapy, chemotherapy, photodynamic therapy, surgery, or other immunotherapy, can be used with the methods and compositions.

[0040] vitamin D compound

[0041] Vitamin D is a fat-soluble vitamin that is essential as a positive regulator of calcium homeostasis. The active form of vitamin D is 1α, 25-dihydroxyvitamin D3, also known as calcitriol. In addition to affecting calcium homeostasis, numerous reports demonstrate the usefulne...

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Abstract

Methods and compositions for treating cancer are described herein. More particularly, the methods for treating cancer comprise administering a vitamin D compound, such as seocalcitol, in combination with at least one additional therapeutic agent, such as an anti-cancer agent or a steroid. Furthermore, disclosed are compositions comprising vitamin D compounds and at least one additional therapeutic agent, such as an anti-cancer agent or a steroid, e.g., corticosteroid or more specifically, a glucocorticoid.

Description

technical field [0001] This document relates to methods and compositions for treating cancer. More specifically, the method of treating cancer comprises administering a vitamin D compound in combination with at least one additional therapeutic agent, such as an anticancer agent or a steroid. Furthermore, compositions are disclosed comprising a vitamin D compound and at least one additional therapeutic agent, such as an anticancer agent or a steroid, such as a corticosteroid, or more particularly a glucocorticoid. Background technique [0002] Cancer is currently the second leading cause of death in the United States after heart disease. As the US population ages, the incidence of cancer is widely expected to increase, and if current trends continue, cancer is expected to emerge as the leading cause of death by 2010. As of now, it is estimated that one in two men in the United States will be diagnosed with cancer at some point in their lifetime, and one in three women in th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P35/00A61K31/592A61K31/593A61K31/573
CPCA61K45/06A61K31/59A61K31/337A61K31/593A61K31/573A61P35/00A61P43/00A61K2300/00A61K9/20
Inventor 艾伦·H·奥尔巴克阿里·S·贝尔德格伦
Owner 库伽尔生物科技公司
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