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Ophthalmic gel containing chondroitin sulfate and method for preparing same

A technology of chondroitin sulfate and ophthalmic gel, which is applied in the direction of medical preparations containing active ingredients, medical preparations with non-active ingredients, and pharmaceutical formulas, which can solve the problems of short retention time of eye drops, low bioavailability, Weak external stimuli and other issues to achieve the effect of avoiding drug loss, simple preparation process, and stable drug release

Active Publication Date: 2011-08-10
SHENYANG XINGQI PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are many domestic manufacturers producing compound chondroitin sulfate eye drops (eye drops containing chondroitin sulfate and taurine), but the retention time of the eye drops in the eyes is short, and 70% of them usually overflow from the eyes during use. , so its bioavailability is low
By increasing the viscosity of the drug, the loss of the drug can be improved and the curative effect can be increased. However, the human eye is relatively weak in tolerance to external stimuli, and it is difficult for general excipients to meet the requirements of thickeners for ophthalmic preparations.

Method used

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  • Ophthalmic gel containing chondroitin sulfate and method for preparing same
  • Ophthalmic gel containing chondroitin sulfate and method for preparing same
  • Ophthalmic gel containing chondroitin sulfate and method for preparing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1. Preparation of ophthalmic gel of the present invention

[0029] Composition of ophthalmic gel:

[0030] components

content

Chondroitin Sulfate

2.0 grams

taurine

0.25 grams

carbomer

4.0 grams

Borax

6.0 grams

Propylene Glycol

5.5 grams

hydrogenated castor oil

10.0 grams

Ethylparaben

0.10 grams

Co-made

500 g

[0031] Preparation Process:

[0032] Take the prescribed amount of carbomer, add an appropriate amount of water for injection, swell, and sterilize for later use; take an appropriate amount of water for injection, add the prescribed amount of ethylparaben to dissolve, add borax; take another prescribed amount of hydrogenated castor oil, add propylene glycol, Miscible with each other, mix well with the previous step, filter through 0.22 microns and add to carbomer; take the prescribed amount of chondroitin sulfate and taurine, add to dissolve, s...

Embodiment 2

[0033] Embodiment 2. Preparation of ophthalmic gel of the present invention

[0034] Composition of ophthalmic gel:

[0035] components

content

[0036] Chondroitin Sulfate

2.0 grams

taurine

0.25 grams

carbomer

4.5 grams

sodium hydroxide

4.0 grams

glycerin

4.2 grams

hydrogenated castor oil

8.0 grams

Benzalkonium chloride

0.12 grams

Co-made

500 g

[0037] Preparation Process:

[0038] Take the prescribed amount of carbomer, add an appropriate amount of water for injection, swell, and sterilize for later use; take an appropriate amount of water for injection, add the prescribed amount of benzalkonium chloride to dissolve, and add sodium hydroxide; Glycerin, miscible with each other, mixed with the previous step, filtered through 0.22 microns and added to carbomer; take the prescribed amount of chondroitin sulfate and taurine, add and dissolve, stir well, add t...

Embodiment 3

[0039] Embodiment 3. Preparation of ophthalmic gel of the present invention

[0040] Composition of ophthalmic gel:

[0041] components

content

Chondroitin Sulfate

2.0 grams

taurine

0.25 grams

carbomer

3.5 grams

hypromellose

1.5 grams

Sodium dihydrogen phosphate

3.5 grams

Mannitol

2.0 grams

hydrogenated castor oil

10.0 grams

Benzalkonium Bromide

0.10 grams

Co-made

500 g

[0042] Preparation Process:

[0043] Take the prescribed amount of carbomer and hypromellose, add an appropriate amount of water for injection, swell, and sterilize for later use; take an appropriate amount of water for injection, add the prescribed amount of benzalkonium bromide to dissolve, add sodium dihydrogen phosphate; take another prescription A certain amount of hydrogenated castor oil, add mannitol, miscible with each other, mix with the previous step, filter through 0.22 microns ...

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Abstract

The invention relates to an ophthalmic gel containing chondroitin sulfate and a method for preparing the same. The ophthalmic gel comprises chondroitin sulfate and taurine in effective dose and an aqueous gel substrate in proper amount. Compared with eyedrop, the ophthalmic gel has the advantages of good biocompatibility, small stimulation, simple preparation process and the like.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to an ophthalmic gel containing chondroitin sulfate and taurine and a preparation method thereof. Background technique [0002] Chondroitin sulfate is a mucopolysaccharide compound extracted from animal cartilage, which has a protective effect on corneal collagen fibers, promotes the growth of fibers in the matrix, enhances permeability, improves blood circulation, accelerates metabolism, promotes the absorption of permeate and inflammation Elimination of corneal trauma to promote healing. With strong water retention, it can improve the water metabolism of corneal tissue and improve the symptoms of eye dryness. It can be used for anticoagulation in surgery, and has a good effect on the treatment of trauma, scars and short scars. It is used for postoperative adhesions and has the functions of detoxification, analgesia and promotion of wound healing. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/737A61K9/00A61K47/38A61P27/02A61K31/185
Inventor 刘继东杨宇春高峨
Owner SHENYANG XINGQI PHARM CO LTD
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