Degradable blood vessel casting agent

A casting and blood vessel technology, applied in the field of bioengineering, can solve the problems such as the difficulty of preparing tissue engineering scaffolds with a blood vessel casting agent, and achieve the effects of good mechanical and physical properties, good compatibility and excellent plasticity

Inactive Publication Date: 2009-09-30
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a degradable casting agent to meet the needs of preparing tissue engineering scaffolds with physiological vascu

Method used

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  • Degradable blood vessel casting agent

Examples

Experimental program
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Effect test

Example Embodiment

[0018] Example 1

[0019] Take 1.0 g of poly-D and L-lactic acid with a molecular weight of 390,000 and place it in a beaker, add 10 ml of ethyl acetate, and after the poly-D and L-lactic acid are completely melted, a polylactic acid casting agent is obtained. Can be used as a vascular mold.

[0020] Use this casting agent to cast live liver blood vessels in rats, then cut the liver and place it at room temperature to dry naturally, then place it in a 25% hydrochloric acid solution to corrode for 3 days, slowly rinse with running water to remove cells and connective tissue, and then use soap After soaking in water for 1 day, a milky white rat liver vascular tree model was obtained. See its photos figure 1 .

Example Embodiment

[0021] Example 2:

[0022] Put 2.0 g of polyglycolic acid in a beaker and add 10 ml of acetone. After the polyglycolic acid is completely melted, the polyglycolic acid casting agent is obtained. Can be used as a vascular mold.

Example Embodiment

[0023] Example 3

[0024] Put 0.5 g of poly D, L lactic acid and 0.5 g of polyglycolic acid in a beaker, add 5 ml of chloroform, 1,4 dioxane, and after the poly D, L lactic acid and polyglycolic acid are completely melted, the polyglycolic acid D, L lactic acid and polyglycolic acid casting agents can be used as blood vessel castings.

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Abstract

The invention relates to a degradable blood vessel casting agent. The casting agent consists of casting material and an organic solvent. 1ml of the casting agent contains 0.05 to 0.5g of the casting material. The casting material is one of polylactic acid, polyglycollic acid and polycaprolactone or the combination of any two; and the organic solvent is acetone, ethyl acetate, chloroform or 1,4-dioxane. The preparation and application process of the casting agent is simple and easily operated. The concentration of the casting agent is timely regulated as required; and the casting agent can be used for feeding a cast many times during casting so as to maintain the natural form of a blood vessel maximally. After being injected into the blood vessel or a blood vessel die, the casting agent can be completely solidified through a plurality of drying methods; and then a blood vessel cast is obtained after the corrosive removal of tissues and cleaning or after opening the blood vessel die. The blood vessel cast prepared from the casting agent has certain toughness and mechanical strength. The casting agent has good biocompatibility, easy molding, and easy percolation and dissolution, and is suitable for the study on the preparation of a hepatic tissue engineering support with a physiological shape blood vessel network.

Description

technical field [0001] The invention relates to a degradable vascular casting agent. It belongs to the technical field of bioengineering. Background technique [0002] Vascular casting technology is a specialized technique for making anatomical specimens, which is widely used in making specimens of vascular network models in animals and human organs, and has high application value in medical teaching and scientific research. At present, the combination of this production technology and computer is used to synthesize a three-dimensional image of the vascular network for the research field of tissue engineering scaffolds. However, the application of the three-dimensional image of the blood vessel network obtained by this method to the preparation of tissue engineering scaffolds still requires special molding equipment. It can be completed, so it is limited due to the complexity of the research process and high cost. [0003] The cast agent is injected into the blood vessel, ...

Claims

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Application Information

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IPC IPC(8): C08L67/04G09B23/28
Inventor 万涛李世普贺建华文和赵飞
Owner WUHAN UNIV OF TECH
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