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High shearing production method for film coating agent

The technology of a film coating agent and production method is applied in the directions of pharmaceutical formulations, medical preparations with inactive ingredients, and drug delivery, etc., which can solve the problems of material loss, long process time, and high energy consumption, and achieve stable performance and color. Vivid, shortened working hours

Active Publication Date: 2011-05-25
TIANJIN BOKELIN MEDICINE PACKAGING TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the colorant needs to be made into a solution first and then dried. The process takes a long time, consumes a lot of energy, and will cause a large loss of materials.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A high-shear production method for a film coating agent, the innovation of which is that the production method includes the following steps:

[0033] (1) Refinement of the colorant: 200 g of medicinal titanium dioxide was added to a closed shearing device for refinement. Shearing equipment can use SRL, SHR, GH, SH and other models of high-speed shear mixers. The shearing equipment has paddles with adjustable speed. The high-speed rotation drives the material to rotate, mix at high speed, and finely disperse the material. The model of the shearing equipment in this embodiment is: GH high-speed shearing mixer. The blade speed of the shearing device is controlled at 2000 rpm, and the time is controlled at 15 minutes to obtain pharmaceutical titanium dioxide with a particle size of 1-30um.

[0034] (2) Coating of coloring agent: 20g surfactant Tween 60 is added distilled water to be diluted into the solution of 50% concentration, adopts high-pressure spray gun that surfac...

Embodiment 2

[0038] A high-shear production method for a film coating agent, the innovation of which is that the production method includes the following steps:

[0039](1) Thinning of the colorant: Add 200g of medicinal iron oxide into a closed shearing device for thinning treatment. The blade speed of the shearing device is controlled at 2500 rpm, and the time is controlled at 30 minutes to obtain medicinal iron oxide with a particle size of 1-30um.

[0040] (2) Coating of coloring agent: 10g surfactant Tween 80 is added distilled water and is diluted into the solution of 40% concentration, adopts high-pressure spray gun that surfactant solution is atomized and sprayed in shearing equipment, maintains the shearing equipment The rotation speed of the paddle is controlled at 2500 rpm, and the shearing treatment is continued for 10 minutes to form the coated colorant.

[0041] (3) Compounding of the coated coloring agent: 740g methyl cellulose is added to the shearing device, the paddle sp...

Embodiment 3

[0044] A high-shear production method for a film coating agent, the innovation of which is that the production method includes the following steps:

[0045] (1) Refining of the colorant: a mixture of 140g of color lake and 60g of pharmaceutical titanium dioxide was added to a closed shearing device for refining. The blade speed of the shearing device is controlled at 3500 rpm, and the time is controlled at 40 minutes to obtain a mixture of color lake and pharmaceutical titanium dioxide with a particle size of 1-30um.

[0046] (2) Coating of coloring agent: Dilute 0.2g of surfactant Span 20 with distilled water to a solution of 30% concentration, and use a high-pressure spray gun to atomize and spray the surfactant solution into the shearing equipment to maintain the shearing equipment The rotating speed of the paddle is controlled at 3500 rpm, and the shearing process is continued for 10 minutes to form the coated colorant.

[0047] (3) Compounding of the coated colorant: 755...

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PUM

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Abstract

The invention relates to a high shearing production method for a film coating agent. The innovation of the invention is that the production method comprises the following steps of: refining of a colorant, coating of the colorant, compounding of the coated colorant, and plasticization of a mixture. The invention provides the innovative high shearing production method for the film coating agent, adopts a high-speed shearing mode to perform dry dispersion on an insoluble colorant, coats a surfactant to prevent the colorant from agglomerating at the same time, finishescomplete mixing of a film former and even distribution of a plasticizer under low-speed shearing conditions, and has the advantages of high production efficiency, low energy consumption, good application performance of obtained finished products of the coating agents and the like.

Description

technical field [0001] The invention relates to the field of chemical pharmacy, in particular to a high-shear production method of a film coating agent. Background technique [0002] The surface of solid pharmaceutical preparations, food, candy or crop seeds is usually sprayed with a film coating agent, which can improve the taste, protect against moisture, improve product stability and bright and pleasing to the eye, especially for drugs, it can also improve its The release characteristics of active ingredients can achieve rapid release, sustained release or controlled release of drugs. Film coating agents are usually mixed with film-forming agents, plasticizers, colorants and other ingredients to form powder or granular materials. In order to ensure the stability of the properties of the coating agent, it is necessary to adopt reasonable processing methods to finely disperse the colorant, and to fully mix and penetrate the film-forming agent, plasticizer and colorant. Ho...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/38A61K47/34A61K47/32A61K9/36A61K47/26
Inventor 赵永建邵广川王岳辉冯萍
Owner TIANJIN BOKELIN MEDICINE PACKAGING TECH
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