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Novel Celosia argentea saponins compounds and application thereof

A kind of technology of ginseng saponins and compounds, which is applied in the field of medicine, and achieves the effects of remarkable activity, simple preparation method and low cost

Inactive Publication Date: 2009-11-04
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The inventor has applied for a patent (Patent No.: ZL200610026789.3) for the components of the saponins of the quinces, the glucosides of the quinces, the glucosides C and glucosinolates, but so far no cyanosins C and cyanosides have been found. D's related reports

Method used

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  • Novel Celosia argentea saponins compounds and application thereof
  • Novel Celosia argentea saponins compounds and application thereof
  • Novel Celosia argentea saponins compounds and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Embodiment 1. Preparation of cyanoside C and cyanoside D

[0014] With 50kg of Fructus L. japonica in Bozhou, Anhui, pulverized and extracted by percolation with 50% ethanol as usual, the extract was concentrated under reduced pressure to obtain a concentrated solution, and the concentrated solution was passed through a D101 macroporous resin column, followed by water, 30% ethanol, 60% ethanol and 95% ethanol gradient elution, 60% ethanol eluate was collected and concentrated under reduced pressure, dried, it was subjected to silica gel column chromatography three times, dichloromethane-methanol-water (9:1:0.1~7:3: 0.3) Solvent system elution, and then reverse phase column ODS-C 18 Purified with Sephadex LH-20 to obtain 25 mg of cyanoside C and 43 mg of cyanoside D, respectively.

[0015] Structure Identification

[0016] 1. Qingruoside C

[0017] White powder, m.p.: 245~247℃, ESI-MS: m / z 797.67[M] - , the molecular weight of the compound was determined to be 798. ...

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Abstract

The invention relates to the technical field of medicaments, in particular to novel Celosia argentea saponins compounds extracted from Celosia argentea L, namely Celosia argentea C and Celosia argentea D. The chemical structural formulas of the compounds are shown by the diagram, wherein the base group R is L-rhamnopyranosyl(1-2)-D-arabinopyranosl or D-glucopyranosy(1-4)-L-rhamnopyranosyl-D-arabinopyranosl. The animal experiments verify that the compounds have the activity of preventing and treating hepatic diseases, cardiovascular and cerebrovascular diseases, metabolic diseases, dementia, depression or anxiety. The compounds have a simple preparation method, low cost, and obvious activity. The invention provides the new compounds for the medicaments capable of preventing and treating hepatic diseases, cardiovascular and cerebrovascular diseases, metabolic diseases, dementia, depression or anxiety.

Description

technical field [0001] The invention relates to the technical field of medicine, and relates to a new Celosia saponin compound Celosia argentea L., Celosia argentea L. disease, dementia, depression or anxiety medication. Background technique [0002] Semen Celosiae is the dry mature seed of Celosia argentea L. in the family Amaranthcea. Bitter in taste, slightly cold in nature, it has the effects of clearing the liver, improving eyesight, dispelling wind-heat, lowering blood pressure and anti-inflammation. It is often used in the treatment of conjunctival congestion and swelling, keratitis, corneal clouding, iridocyclitis, vertigo, skin itching due to wind-heat, and scabies. The inventor has applied for a patent (Patent No.: ZL200610026789.3) for the components of the saponins of the quinces, the glucosides of the quinces, the glucosides C and glucosides. D related reports. Contents of the invention [0003] The present invention provides a new quincenoside compound cy...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J63/00A61K31/7024A61P1/16A61P9/00A61P3/00A61P25/28A61P25/24A61P25/22
Inventor 郭美丽孙振亮游孟涛张福金
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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