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Application of hypertonic injection to preparation of medicament accelerating wound healing

A wound healing and drug technology, which is applied in the field of the use of hypertonic injections in the preparation of wound healing-promoting drugs, can solve the problems of undisclosed hypertonic injections, etc., and achieve the effects of reducing inflammatory response, being safe and convenient to use, and promoting healing.

Inactive Publication Date: 2009-11-18
BEIJING SHENKELIANHUA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

No disclosure or disclosure of the medical use of hypertonic injections for promoting wound healing

Method used

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  • Application of hypertonic injection to preparation of medicament accelerating wound healing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] 1. Formulation:

[0030] Hydroxyethyl starch 40 76 grams

[0031] Sodium chloride 42 grams

[0032] Add water for injection to 1000ml

[0033] 2. Preparation method:

[0034] Dissolve 76g of hydroxyethyl starch 40 in 500ml of water for injection, add 5g of activated carbon, stir and heat at 90°C for 12 minutes, filter and add 42g of sodium chloride and stir to dissolve, add water for injection to 1000ml, add 5-10 grams of activated carbon, stirred and heated at 90°C for 10 minutes, filtered with a 0.22μm microporous membrane. Fill the resulting filtrate into 20ml, 50ml, 100ml, 250ml, 300ml, 500ml, 750ml, 1000ml or 1500ml plastic bags, plastic bottles or glass bottles, seal and pass through 1.05kg / cm 2 and sterilizing at 121-123° C. for 15-30 minutes to obtain a hypertonic injection pharmaceutical composition.

Embodiment 2

[0036] 1. Formulation:

[0037] Dextran 70 60g

[0038] Sodium chloride 75 grams

[0039] Add water for injection to 1000ml

[0040] 2. Preparation method:

[0041] Dissolve 60g of dextran 70 in 500ml of water for injection, add 5g of activated carbon, stir and heat at 90°C for 12 minutes, add 75g of sodium chloride after filtration and stir to dissolve, add water for injection to 1000ml, add 5-10 gram of activated carbon, stirred and heated at 90°C for 10 minutes, and filtered through a 0.22 μm microporous membrane. Fill the resulting filtrate into 20ml, 50ml, 100ml, 250ml, 300ml, 500ml, 750ml, 1000ml or 1500ml plastic bags, plastic bottles or glass bottles, seal and pass through 1.05kg / cm 2 and sterilizing at 121-123° C. for 15-30 minutes to obtain a hypertonic injection pharmaceutical composition.

Embodiment 3

[0043] 1. Formulation:

[0044] Hydroxyethyl starch 200 / 0.5 60g

[0045]Sodium chloride 72 grams

[0046] Add water for injection to 1000ml

[0047] 2. Preparation method:

[0048] Dissolve 60g of hydroxyethyl starch 200 / 0.5 in 500ml of water for injection, add 5g of activated carbon, stir and heat at 90°C for 12 minutes, add 72g of sodium chloride after filtration and stir to dissolve, add water for injection to 1000ml , add 5-10 grams of activated carbon, stir and heat at 90° C. for 10 minutes, and filter with a 0.22 μm microporous membrane. Fill the resulting filtrate into 20ml, 50ml, 100ml, 250ml, 300ml, 500ml, 750ml, 1000ml or 1500ml plastic bags, plastic bottles or glass bottles, seal and pass through 1.05kg / cm 2 and sterilizing at 121-123° C. for 15-30 minutes to obtain a hypertonic injection pharmaceutical composition.

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Abstract

The invention relates to the application of hypertonic injection to the preparation of medicament accelerating wound healing. The hypertonic sodium chloride hydroxyethyl starch 40 injection, the hypertonic sodium chloride dextran 70 injection or the hypertonic sodium chloride hydroxyethyl starch 200 / 0.5 injection is preferentially used. The medicament is used for accelerating the healing of scratch, contusion, puncture, burn, incision, operation, frostbite, bite wound or wound caused by acidic material, alkaline material or corrosive material particularly in the perioperative period as the injection.

Description

technical field [0001] The present invention relates to a new medical application of hypertonic injection, in particular to the application of hypertonic injection in the preparation of medicine for promoting wound healing. It belongs to the field of medicine. Background technique [0002] A wound is one in which the integrity of the skin is compromised and the normal protective functions of the body cannot be maintained. In daily life, people often suffer injuries and wounds due to negligence or some accidents. This will not only cause pain, but more importantly, any small wound on the body may be infected and damaged by pathogens if it is not handled properly. The degree of wound infection is closely related to the size, depth, and degree of contamination of the wound. Mildly infected wounds only have local symptoms of redness, swelling, heat, and pain. In addition to obvious local symptoms on the wound, those with severe infection may also have systemic poisoning symp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/718A61P17/02
Inventor 申静
Owner BEIJING SHENKELIANHUA TECH
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