Compound fluconazole ointment and preparation method thereof

Abstract

The invention relates to a compound fluconazole ointment prepared from fluconazole, neomycinsulphate, vaseline, lanolin, liquid paraffin, stearic acid, span-80, span-85, tween-80, sorbic acid, A-200, A-380, glycerol, DMF, ethyl acetate and distilled water. The invention uses new-generation triazole type medicine fluconazole to substitute nystatin in erfuling, combines fluconazole and neomycinsulphate to treat deep mycotic infection and has favorable curative effect. The ointment has enlarged antimicrobial spectrum, enhanced bacterium resistance and reduced toxic or side effect and can achievethe effect of deep therapy. Medicine-sensitive and clinical experiments indicate that the invention can effectively control the itch disease of the auditory canals of animals and the infection of mould fungi and microzyme in the skin and the auditory canals, is also effective to the local mycotic infection of dogs and cats and also can treat any possible primary and secondary bacterial infection.The compound fluconazole ointment is applied to the surfaces of the skin and the auditory canals and can effectively relieve inflammatory reactions and itch.

Description

technical field [0001] The invention relates to a compound fluconazole ointment for treating ear canal or skin fungus infection of pets such as dogs and cats and a preparation method thereof. Background technique [0002] Mycosis of the ear canal is mostly caused by the increase in environment and humidity that is conducive to the growth of fungi or that chronic otitis media is easily combined with fungal infections. Dogs, cats and other pets have a high probability of suffering from ear canal diseases and skin infections. At present, there is a shortage of drugs for the treatment of ear canal fungal infections in the domestic market. The commonly used ointment preparation for the treatment of pet ear canal infection is the Erfuling ointment of France Weilong Oridermyl. The main components of the Erfuling ointment are neomycin sulfate and nystatin. Nystatin is mostly used for the treatment of superficial fungi, and topical application is not absorbed by the skin and mucous ...

AI Technical Summary

Problems solved by technology

The main components of the Erfuling ointment are neomycin sulfate and nystatin. Nystatin is mostly used for the treatment of superficial fungi, and local application is not absorbed by the skin and mucous membranes, and it is highly toxic and lacks specificity.