Devices and methods for detecting ss-haematin and haemozoin

A detection device, hemoglobin technology, applied in the direction of measuring device, diagnostic recording/measurement, diagnosis using light, etc., can solve the problems of expensive, limited use, non-quantifiable, etc.
CN101600962AActive Publication Date: 2009-12-09COTTON MOUTON DIAGNOSTICS LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
COTTON MOUTON DIAGNOSTICS LTD
Publication Date
2009-12-09

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Abstract

In the application, the change in the magnetic state of the haemoglobin caused by the malarial infection is exploited by detecting suitable properties of haemozoin which are dependent on the application of a magnetic field. FIG. 1 shows apparatus, shown generally at (10), for performing magneto-optical detection using photo-acoustic techniques. The apparatus (10) comprises a light source (12), producing a beam of optical radiation (14) which passes through a polariser (16), a variable LC retarder (0 or 180 DEG retardance) (18), and a (chopper 20), before impinging on a sample (22) held in a sample holder (24). The sample is in direct contact with an acoustic detector (26). The apparatus (10) further comprises an electromagnet (28), and a Gauss meter (30) can be utilised to measure the applied magnetic field strength. Advantages associated with this approach are the-possibility of making in vivo measurements, and the avoidance of problems of optical scattering associated with conventional optical measurements on turbid liquids such as whole blood.
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Description

technical field

[0001] The present invention relates to devices and methods for the detection of beta-heme (haematin) and malaria pigment (haemozoin), and in particular (but by no means meant exclusively) to the detection of malaria. Background technique

[0002] Malaria remains a serious health problem in many parts of the world. Unfortunately, in areas where malaria is endemic, the best diagnostic tools available require use in a laboratory setting. As a result, effective treatment is often not available due to lack of timely and accurate diagnosis and high cost and eradication. Even in Europe, the number of illnesses and deaths is increasing year by year due to the increasing preference of Europeans for holidays in malaria-endemic areas but at the same time their reluctance to take antimalarial prophylaxis. Native Europeans are not immune, and as a result, the infection can (and often does) cause rapid death because it is not diagnosed early. Moreover, the situation is...

Claims

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