Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Devices and methods for detecting ss-haematin and haemozoin

A detection device, hemoglobin technology, applied in the direction of measuring device, diagnostic recording/measurement, diagnosis using light, etc., can solve the problems of expensive, limited use, non-quantifiable, etc.

Active Publication Date: 2009-12-09
COTTON MOUTON DIAGNOSTICS LTD
View PDF0 Cites 9 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these tests are expensive, not quantifiable, and of limited use in detecting low-level parasitemia (<100 parasites / microliter)

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Devices and methods for detecting ss-haematin and haemozoin
  • Devices and methods for detecting ss-haematin and haemozoin
  • Devices and methods for detecting ss-haematin and haemozoin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0070] An important aspect of the invention is its use in the detection of Plasmodium, although the invention is applicable to the detection of malaria pigments and beta-heme itself. The malaria parasite enters the erythrocyte (red blood cell) and converts the hemoglobin into malarin, changing its magnetic state in the process. The red blood cells then rupture, releasing malaria pigment into the plasma, while the malaria parasite continues to infect the red blood cells. The present inventors have found that it is possible to detect malaria parasites by detecting the presence of malaria pigments in blood.

[0071] In some particularly preferred embodiments, changes in the magnetic state of hemoglobin caused by malarial infection are exploited by detecting the proper properties of the malaria pigments, which depend on the application of a magnetic field.

[0072] In a preferred embodiment, photoacoustic detection is used. Advantages associated with this approach are that in vi...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
wavelengthaaaaaaaaaa
Login to View More

Abstract

In the application, the change in the magnetic state of the haemoglobin caused by the malarial infection is exploited by detecting suitable properties of haemozoin which are dependent on the application of a magnetic field. FIG. 1 shows apparatus, shown generally at (10), for performing magneto-optical detection using photo-acoustic techniques. The apparatus (10) comprises a light source (12), producing a beam of optical radiation (14) which passes through a polariser (16), a variable LC retarder (0 or 180 DEG retardance) (18), and a (chopper 20), before impinging on a sample (22) held in a sample holder (24). The sample is in direct contact with an acoustic detector (26). The apparatus (10) further comprises an electromagnet (28), and a Gauss meter (30) can be utilised to measure the applied magnetic field strength. Advantages associated with this approach are the-possibility of making in vivo measurements, and the avoidance of problems of optical scattering associated with conventional optical measurements on turbid liquids such as whole blood.

Description

technical field [0001] The present invention relates to devices and methods for the detection of beta-heme (haematin) and malaria pigment (haemozoin), and in particular (but by no means meant exclusively) to the detection of malaria. Background technique [0002] Malaria remains a serious health problem in many parts of the world. Unfortunately, in areas where malaria is endemic, the best diagnostic tools available require use in a laboratory setting. As a result, effective treatment is often not available due to lack of timely and accurate diagnosis and high cost and eradication. Even in Europe, the number of illnesses and deaths is increasing year by year due to the increasing preference of Europeans for holidays in malaria-endemic areas but at the same time their reluctance to take antimalarial prophylaxis. Native Europeans are not immune, and as a result, the infection can (and often does) cause rapid death because it is not diagnosed early. Moreover, the situation is...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/487A61B5/00A61B5/1455
CPCG01N21/21A61B5/05G01N2201/0697A61B5/0095G01N2021/218A61B5/0059G01N2201/067G01N21/1717A61B5/6816A61B5/6838G01N2333/445G01N2021/1727A61B5/6826
Inventor 大卫·麦克尔·纽曼约翰·赫普汀斯特
Owner COTTON MOUTON DIAGNOSTICS LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com