Synthetic method and application of N, N'-bis-[3-hydroxy-4-(2-benzothiazole)phenyl] carbamide

A technology for the synthesis of benzothiazoles, which is applied in the chemical field, can solve the problems of difficult post-processing, low reaction yield, and difficult preparation, and achieve the effects of high yield, high detection sensitivity, and mild reaction conditions
CN101602745AInactive Publication Date: 2009-12-16DALIAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
DALIAN UNIV
Publication Date
2009-12-16
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to the field of chemistry, in particular to a synthetic method and application of N, N'-bis-[3-hydroxy-4-(2-benzothiazole)phenyl] carbamide. The molecular structural formula of the N,N'-2-[3-hydroxy-4-(2-benzothiazole)phenyl] carbamide is shown at the right; and the synthetic method of the N, N'-bis-[3-hydroxy-4-(2-benzothiazole)phenyl] carbamide comprises the step that 2-(4-amido-2-hydroxybenzene radical) benzothiazole, 4-AHBA for short, and carbonyl imidazole, CDI for short, are used as raw materials and react in toluene, benzene or xylene solvents to obtain the N, N'-bis-[3-hydroxy-4-(2-benzothiazole)phenyl] carbamide, for short 4-DHBTU. The reaction equation is shown at the right upper part. The invention has available reaction raw materials, mild reaction conditions and high yield; any other catalysts and (or) reaction auxiliary agents do not need to be added in the reaction process, the operation is simple and safe, the phenolic hydroxyl radical of the 4-AHBA does not need to be protected, and the recovery of a byproduct of the imidazole is convenient; and the 4-DHBTU is used as a fluorescent probe and used for the detection of Zn, the concentration lower limit of the Zn is measured and can reach 1*10mol / L, and Fe, Fe, Cd, Co, Mn, Cu, Ni, Ag, Sn, La and Pb all do not interfere the measurement of the concentration of the Zn.
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Description

technical field

[0001] The invention relates to the field of chemistry, in particular to a kind of excited state intramolecular proton transfer-urea derivative N, N'di-[3-hydroxyl-4-(2-benzothiazole)phenyl]urea (4-DHBTU) A new synthetic method; and the compound as a fluorescent probe in Zn 2+ application in detection. Background technique

[0002] Excited-state intramolecular proton transfer (ESIPT)-urea derivatives are widely used in chemical sensors, laser dyes, and UV light stabilizers. Typical methods for the synthesis of urea derivatives include the addition of amines to isocyanates and the reaction of amines with carbamoyl halides. However, due to the disadvantages of difficult preparation of raw materials, instability, low reaction yield, and difficult post-processing, the application range of these methods is limited to a certain extent. Contents of the invention

[0003] The object of the present invention is to provide a novel excited state intramolecular prot...

Claims

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