Decoquinate soluble powder and preparation method thereof

Abstract

The invention provides ecoquinate soluble powder and a preparation method thereof. The preparation method comprises the steps: evenly mixing ecoquinate and a solid dispersion carrier together; heating the mixture to a fusing state at the temperature of 120DEG C to 150 DEG C; then, airing and crashing the mixture at room temperature; adding anhydrous dextrose to obtain the ecoquinate soluble powder. The decoquinate soluble powder comprises 1 percent to 20 percent of ecoquinate, 4 percent to 80 percent of solid dispersion carrier and anhydrous dextrose. The prepared soluble powder has good solubility and high stability, the property and the solubility of the soluble powder are not changed after being stored for 6 mouths under an accelerating test condition (40DEG C+ / -2DEG C) or being stored for 1 year at room temperature (25DEG C+ / -2DEG C ), the content of the ecoquinate soluble powder is reduced and meets the requirements of galenic pharmacy, the effective period of the ecoquinate soluble powder can be as long as 3 years by calculation, the content reduction is not obvious under an illumination experiment condition, and the content of drug active ingredients can be maintained above 90 percent for four hours in water. A prepared drug preparation has good effect and convenient use and has good popularization and application value.

Description

technical field [0001] The invention relates to a soluble powder process for livestock and poultry, in particular to a soluble powder of anticoccidial drug preparation decoquinate and a preparation method thereof. Background technique [0002] Chicken coccidiosis is mainly caused by intestinal parasites of the genus Eimeria. Chicken coccidiosis has the following characteristics: one is ubiquitous and occurs widely. Coccidiosis occurs in almost all places where chickens are raised, especially in today's development of large-scale and intensive poultry farming, the impact of coccidiosis on poultry has been quite prominent. If coccidiosis cannot be effectively controlled, the incidence rate of chickens can reach 50% to 70%, the mortality rate can reach 20% to 30%, and when it is severe, it can reach 80%, and it is easy to induce other diseases. Coccidiosis has become a global disease hindering the development of intensive chicken production. The second is that it is very har...

AI Technical Summary

Problems solved by technology

The second is that it is very harmful. The harm caused by coccidiosis to chickens can be summarized in three aspects: 1. It causes a large number of morbidity and death of chickens; 2. It hinders the growth and development of chickens, and the weight loss can reach 30-70%; 3. , reduce feed remuneration

However, with the widespread use of anticoccidial drugs and improper use methods, chicken coccidia have developed a certain degree of drug resistance to almost all used anticoccidial drugs, resulting in shortened service life of anticoccidial drugs and the prevention and control of coccidiostats. Failure or poor effect, such as salinomycin, sulfa drugs, maduramycin, monensin, loxanthine, etc. Coccidia drug resistance has become the most serious problem in the prevention and control of chicken coccidiosis. Caused huge economic losses to the poultry industry

In addition, since the European Union, Japan, the United States, etc., the list of drugs that are not allowed to be added to imported poultry products includes a variety of anticoccidial drugs, resulting in great restrictions on the application of anticoccidial drugs

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