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Composition for external application to skin

一种外用组合物、皮肤的技术，应用在皮肤疾病、药物组合、护理皮肤的制剂等方向，能够解决很可能涂抹于靠近鼻子的脸部等、保湿性的持续能力差、保湿效果不高等问题，达到优异保湿效果、使用感优异、保湿持续性优异的效果

Inactive Publication Date: 2010-02-10
SHISEIDO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since they are low-molecular-weight compounds, they can be expected to penetrate into the stratum corneum and function by themselves, but the moisturizing effect of these compounds themselves is not high
Moreover, since these compounds have high crystallinity and low solubility to solvents other than water, when they are mixed into external skin compositions, they will precipitate with water evaporation after being applied, and the retention of moisture retention is poor. At the same time, penetration into the stratum corneum is suppressed
In addition, especially amino acids can cause sensory irritation, such as glycine, β-alanine, GABA (γ-aminobutyric acid), etc., especially users with sensitive skin will feel skin irritation when applying it, so cooperate with Quantity is limited
In addition, there is also a problem of odor. For example, low-molecular-weight basic amino acids such as lysine have an amine-like odor. Therefore, the amount of compounding in skin external compositions that are likely to be applied to the face near the nose is still limited.

Method used

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  • Composition for external application to skin
  • Composition for external application to skin
  • Composition for external application to skin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0038] The present invention will be described in more detail below by listing examples. The present invention is not limited thereto.

manufacture example

[0040] Dissolve 2.2 g of N,N'-dibenzyloxycarbonyl-L-lysine in 40 mL of dichloromethane, add 1.9 g of β-alanine benzyl ester tosylate, 1.5 mL of triethylamine at room temperature , 1.0 g of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride, 0.8 g of 1-hydroxybenzotriazole, stirred for 3 hours. Diluted with 100 mL of dichloromethane, washed with 50 mL of purified water, 50 mL of 2M hydrochloric acid, and 50 mL of saturated brine, dried over anhydrous magnesium sulfate, and concentrated after filtration. 200 mL of methanol was added to the obtained residue, and 0.5 g of palladium carbon (5%, humidity 50%) was added, stirred at room temperature for 2 hours under a hydrogen atmosphere, filtered and concentrated to obtain 1.1 g (96%) of the target compound.

[0041] [Skin stratum corneum moisturizing effect test]

Embodiment 1

[0044] L-lysyl-β-alanine 5.0% by mass

[0045] 1N hydrochloric acid adjusted to pH7.5

[0046] Cosmetic alcohol 50.0

[0047] purified water remaining

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PUM

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Abstract

Disclosed is a humectant or composition for external application to skin, which contains one or more compounds selected from the group consisting of lysyl-ss-alanine represented by the general formula(1) below and salts thereof.

Description

technical field [0001] The present invention relates to compositions for external use on skin. [0002] More specifically, it relates to a moisturizer which is excellent in safety, excellent in usability, excellent in permeability, acts directly on the stratum corneum to increase the moisture content in the stratum corneum, and is excellent in continuous moisturizing effect, and relates to directly acting on the stratum corneum to increase the moisture content of the stratum corneum A composition for external use on skin that has moisture in the layer, is excellent in safety, stability, usability, moisturizing effect, and wrinkle prevention and improvement effect. Background technique [0003] Aging is going on in the organs of the whole body. Among them, for the skin that can be noticed by the naked eye, especially the face that is particularly easy to attract attention, the wrinkles and fine lines that occur at the same time as aging cause many middle-aged and elderly peop...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/44A61K31/197A61P17/16A61Q1/02A61Q1/12A61Q19/00A61Q19/08
CPCA61K8/64A61Q19/007A61K31/197A61K8/44A61P17/16A61P19/00A61K31/198
Inventor 常长诚落合信彦上沼三纪子末继胜
Owner SHISEIDO CO LTD
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