Multi-unit cell tension and compression device

Abstract

A multi-unit cell stretching and compressing device is composed of a control unit, a key unit, a display unit, a drive unit, a power loading unit, a cell culture unit and a power supply for supplying working current to the control unit and the drive unit. The power loading unit includes a motor, a screw, a nut, a beam, a guide mechanism, a cell culture membrane tension in-situ detector and a cell culture membrane compression in-situ detector. There are at least two cell culture units, and each cell culture unit is connected to the beam respectively. . The cell culture unit has a preloading function, and its components include the bottom of the box, the box body, the glass window, the fixed end clamp, the fixed end locking screw, the movable end clamp, the clamp guide bar, the movable end clamp, and the movable end lock. Screws and preloaded screws. This kind of cell force tension and compression device can simultaneously apply one-dimensional periodic or continuous dynamic tension or compression force to cells in multiple cell culture units during the growth process, and the tension or compression strain is adjustable, Stretch or compress frequency adjustable.

Description

technical field [0001] The invention relates to an apparatus for applying one-dimensional (uniaxial) stretching (stretching) force or compressive force to cells in the growth process. Background technique [0002] The growth and development of body tissues and cells are in a complex mechanical microenvironment, and mechanical stimuli play an important role in regulating the physiological and pathological states and functions of cells. Using cell mechanics methods to study the responses of various tissues and cells under different mechanical loads to explore the mechanism of tissue growth and remodeling under normal and abnormal mechanical states has become one of the hotspots in international research. [0003] To carry out research on cell mechanics methods, a cell mechanics loader is required. The patent application with the publication number CN 1425905A provides a four-point bending cell mechanical loading instrument, which satisfies the loading requirements of small st...

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Problems solved by technology

The patent application with the publication number CN 1425905A provides a four-point bending cell mechanical loading instrument, which satisfies the loading requirements of small strains to a certain extent, but with the deepening of cell mechanics research, such strains have been Can not meet the needs of large strain research

The patent application with the publication number CN 1932510A provides a cell tension loading device, and the patent application with the authorized announcement number CN100514059C provides a sinusoidal tension cell loading device. Although these two cell loading devices can meet the needs of large strain , but they can only apply one-dimensional periodic stretching force (stretch force) to cells, but cannot apply one-dimensional continuous stretching force to cells, let alone one-dimensional periodic or continuous compressive force on cells, and its Only one cell culture unit can be stretched at a time, so the scope of application is limited and research efficiency is affected

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