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Column temperature monitoring apparatus and chromatographic apparatus

A technology for monitoring equipment and chromatographic columns, applied in the field of chromatographic equipment, can solve the problems of insufficient pre-heating, insufficient pre-heating, and reduced analysis accuracy, and achieve the effects of consistent analysis conditions, improved accuracy, and improved analysis accuracy.

Inactive Publication Date: 2010-02-24
SHIMADZU SEISAKUSHO CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Even in this configuration, insufficient preheating reduces analytical precision: whether preheating is sufficient needs to be judged experimentally based on the temperature of the air in the constant temperature bath, room temperature, and other factors
Therefore, wrong judgments lead to insufficient preheating and possible loss of analytical precision

Method used

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  • Column temperature monitoring apparatus and chromatographic apparatus
  • Column temperature monitoring apparatus and chromatographic apparatus
  • Column temperature monitoring apparatus and chromatographic apparatus

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Embodiment Construction

[0062] A liquid chromatography (LC) apparatus using a column temperature monitoring apparatus according to an embodiment of the present invention will be described with reference to the accompanying drawings. figure 1 It is a configuration diagram of the main part of the LC device.

[0063] In the LC apparatus, a liquid sending pump 2 sucks the mobile phase held in a mobile phase container 1 and sends the mobile phase to a column 4 through an auto sampler 3 at a constant flow rate. The auto sampler 3 includes a syringe, and selects a specific sample from various samples that have been prepared in advance, and injects the sample into the mobile phase. The injected sample carried by the mobile phase is introduced into the chromatography column 4 . While passing through column 4, the sample is briefly separated and eluted from there. As described above, the chromatography column 4 is contained in the constant temperature bath 5 which can be controlled at a constant temperature....

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Abstract

A column temperature monitoring apparatus is provided in which the analysis reproducibility and analysis accuracy are improved by increasing the accuracy of the control of a column temperature. A sensor unit 10 is attached to a column 4 in such a manner that a temperature sensor 11 touches the outer surface of the column 4, and the temperature data read by the temperature sensor 11 is provided toa temperature controlling / processing unit 20 provided in a constant temperature bath 5 via a wired or wireless communication path 30. The temperature controlling / processing unit 20 temperature-controls the column by controlling the heating current supplied to a heater 51 so that the actually obtained column temperature reaches the target temperature indicated from the controller / processor 7. In the column temperature monitoring apparatus according to the present invention, a temperature controlling is performed based not on the temperature of air inside the constant temperature bath or a heatblock but on the temperature of the outer surface of the column, which enhances the accuracy of the column temperature's detection.

Description

technical field [0001] The invention relates to a chromatographic column temperature monitoring device for controlling the temperature of a chromatographic column in liquid chromatography and gas chromatography and a chromatographic device using the chromatographic column temperature monitoring device. Background technique [0002] In liquid chromatography (LC) analysis, the component retention properties of the chromatographic column, the viscosity of the mobile phase, and other properties are affected by temperature. Therefore, it is important to keep the column temperature constant in order to obtain high analytical reproducibility. In addition, in order to ensure the consistency of analytical results (ie, chromatograms) obtained on the same sample by multiple LC devices, the accuracy of column temperature control is very important. Given these considerations, in LC analysis (especially, now mainstream high-performance liquid chromatography (HPLC) analysis), a constant t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/54G01N30/02
CPCG01N2030/3084G01N2030/3007G01N30/30
Inventor 北川尚卫
Owner SHIMADZU SEISAKUSHO CO LTD
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