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Method for producing storage-stable solutions from pelargonium extracts

A technology of geranium extract and storage stability, which is applied in the field of preparation of storage stability solution of geranium extract, and can solve problems such as insufficient storage stability

Active Publication Date: 2015-03-25
DR VILMAR SHVABE GMBKH EHND KO KG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, solutions of geranium extracts such as liquid herbal formulations containing these extracts of geranium angustiflora and / or geranium nephrifolia in the form of solutions have the disadvantage of insufficient storage stability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0035] Example 1 (comparative example) :

[0036]A solution containing 80% by weight of the above ethanol-aqueous Pelargonium angustifolia extract and 20% by weight of glycerin was filled into a brown glass bottle under normal atmospheric conditions (21% oxygen). The fill volume is 20ml and the headspace volume of the bottle is 5ml. The bottle is equipped with a drop dispenser and tightly sealed with a screw cap. The oxygen content in the headspace was 0.053 parts by volume of oxygen per part by volume of solution. After storage for 9 months at 25°C / 60% relative humidity, the proanthocyanidin content of the solution as determined by the Folin-Siocart method and the content of compounds I and II as determined by HPLC both decreased.

[0037] substance

example 2

[0038] Example 2 (reduction in headspace volume):

[0039] A solution containing 80% by weight of the above ethanol-aqueous Pelargonium angustifolia extract and 20% by weight of glycerin was filled into a brown glass bottle under normal atmospheric conditions (21% oxygen). The fill volume is 23ml and the headspace volume of the bottle is 2ml. The bottle is equipped with a drop dispenser and tightly sealed with a screw cap under normal atmospheric conditions. The oxygen content in the headspace was 0.018 parts by volume of oxygen per part by volume of solution. After storing for 9 months at 25° C. / 60% relative humidity, the proanthocyanidin content of the solution measured by the Folin-Theo Carter method and the content of compounds I and II measured by HPLC were not as good as in example 1 ( Comparative example) significantly reduced.

[0040] substance

example 3

[0041] Example 3 (Protective gas intake with nitrogen gas)

[0042] A solution containing 80% by weight of the above ethanol-aqueous Pelargonium angustifolia extract and 20% by weight of glycerol was poured into a brown glass bottle under normal atmospheric conditions. The fill volume is 20ml and the headspace volume of the bottle is 5ml. The bottle is covered with a nitrogen blanket, equipped with a drop dispenser and tightly sealed with a screw cap. The measured oxygen content in the headspace after sealing was 7%. The oxygen content in the headspace was 0.018 parts by volume of oxygen per part by volume of solution. After storing for 9 months at 25° C. / 60% relative humidity, the proanthocyanidin content of the solution measured by the Folin-Theo Carter method and the content of compounds I and II measured by HPLC were not as good as in example 1 ( Comparative example) significantly reduced.

[0043] substance

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PUM

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Abstract

Solution production involves reducing oxygen quantity to 0.025, preferably 0.005 volume parts per volume part of the solution at atmospheric pressure in the head area of a container. The container is used for storing the solution of Pelargonium extract. Content is reduced by proanthocyanidin and 2H-1-benzopyran-2-one after 9 months storage at 25[deg] C and a relative air humidity of 60%. The oxygen quantity is reduced by mechanical blowing with an inert gas, by a reduced volume of the head area or by addition of an oxygen-removing agent. The agent consists of one or multiple substances.

Description

technical field [0001] The present invention relates to a process for the preparation of a storage-stable solution of geranium extract, characterized in that the amount of oxygen at atmospheric pressure in the headspace of a package for storing the geranium extract solution is reduced to at most 0.025 parts by volume per part by volume of the solution ( Preferably 0.015 parts by volume, especially preferably 0.005 parts by volume), wherein the contents of proanthocyanidins and 2H-1-benzopyran-2-one are each reduced after storage at 25° C. and 60% relative humidity for 9 months Up to 10% by weight (preferably up to 7% by weight, especially preferably up to 5% by weight, especially up to 3% by weight), the amount of oxygen is reduced by: a) feeding with inert gas, and / or b) reducing volume of small headspace, and / or c) addition of an oxygen scavenger consisting of one or more substances and having an nature. Background technique [0002] The geranium extract solution used in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/00A61K36/185
CPCA61K36/185A61K47/10A61K47/02A61K47/12
Inventor 斯得凡·桔门荷尔曼·豪尔马克·斯瓯尔
Owner DR VILMAR SHVABE GMBKH EHND KO KG