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Preparation method of hyaluronic acid-chitosan biomembrane

A technology of hyaluronic acid and biofilm, which is applied in medical science, surgery and other directions to achieve the effect of reducing medical expenses, inhibiting fibroblast proliferation and low price

Inactive Publication Date: 2010-03-24
上海建华精细生物制品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the scarring of the filtration channel after glaucoma surgery is the biggest obstacle to the success of glaucoma surgery due to the biologically inherent wound healing mechanism

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Take purified aseptic pyrogen-free hyaluronic acid 2g, carboxymethyl chitosan 0.25g, polyvinyl alcohol 0.25g, dissolve in water;

[0025] Add 6.5ml of a 1% solution of butanediol diglycidyl ether as a crosslinking agent, add water to 100ml, and stir evenly.

[0026] Salivation method film.

[0027] Dry in a vacuum desiccator.

[0028] After the film dries, cut into small pieces with a sterile razor blade.

[0029] Packed aseptically and soaked in PBS buffer solution of pH 7.4 when used.

Embodiment 2

[0031] Take purified aseptic pyrogen-free hyaluronic acid 1.5g, carboxymethyl chitosan 0.15g, polyvinyl alcohol 0.15g, dissolve in water;

[0032] Add 5ml of a 1% solution of butanediol diglycidyl ether as a crosslinking agent, add water to 100ml, and stir evenly.

[0033] Salivation method film.

[0034] Dry in a vacuum desiccator.

[0035] After the film dries, cut into small pieces with a sterile razor blade.

[0036] Packed aseptically and soaked in PBS buffer solution of pH 7.4 when used.

Embodiment 3

[0038] Example 2

[0039] Take purified aseptic pyrogen-free hyaluronic acid 2g, carboxymethyl chitosan 0.15g, polyvinyl alcohol 0.15g, dissolve in water;

[0040] Add 5ml of a 1% solution of butanediol diglycidyl ether as a crosslinking agent, add water to 100ml, and stir evenly.

[0041] Salivation method film.

[0042] Dry in a vacuum desiccator.

[0043] After the film dries, cut into small pieces with a sterile razor blade.

[0044] Packed aseptically and soaked in PBS buffer solution of pH 7.4 when used.

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Abstract

The invention provides a preparation method of a hyaluronic acid-chitosan biomembrane, wherein the biomembrane, which contains hyaluronic acid and carboxymethyl shitosan, is prepared by the crosslinking reaction of hyaluronic acid, carboxymethyl shitosan and polyvinyl alcohol in the presence of a crosslinking agent. The hyaluronic acid-chitosan biomembrane of the invention has good biological compatibility and longer half-life, and is favorable to improve the success rate of the glaucoma filtration operation and widely popularize the non - penetrating trabecular operation.

Description

technical field [0001] The invention relates to a preparation method of a hyaluronic acid-chitosan biofilm. Background technique [0002] Hyaluronic Acid (HA) gel is widely used in ophthalmology, orthopedics, gynecology, plastic surgery and other fields. It has been in clinical practice for more than ten years, and its safety and effectiveness have been recognized by all medical circles. generally accepted. Natural exogenous hyaluronic acid has a molecular weight of about 100,000 to 5 million Daltons, and its retention time in the body is about 3 to 15 days, which largely limits its application in certain fields. [0003] Chitosan is the second largest polysaccharide in the biological world after cellulose. Domestic and foreign studies have confirmed that chitosan has bioadhesion and various biological activities, including chitosan can promote the growth of epithelial cells , Inhibit the proliferation of fibroblasts, inhibit the proliferation of tumor cells, inhibit the g...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/04A61L31/14
Inventor 孔淑静任彩霞丁玲
Owner 上海建华精细生物制品有限公司
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