Compound preparation for treating cold and preparation method thereof

A compound preparation and preparation technology are applied in the field of medicinal compound preparations for treating colds and their preparation, and the fields of medicinal compound preparations and preparations thereof, which can solve the problems of unstable clinical efficacy, fluctuation of blood drug concentration, and trouble for patients.

Inactive Publication Date: 2010-03-31
BEIJING SIHUAN KEBAO PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] As we all know, the preparation quality of a drug will greatly affect the clinical application value of the drug. No matter what kind of preparation, the blood drug concentration after entering the body must be within the therapeutic window to exert a normal therapeutic effect. produce toxic side effects
It has been found through research that for drugs with a short half-life, large doses of drugs must be administered multiple times in clinical practice to achieve the therapeutic purpose, which not only causes "peak-valley" fluctuations in blood drug concentr

Method used

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  • Compound preparation for treating cold and preparation method thereof
  • Compound preparation for treating cold and preparation method thereof
  • Compound preparation for treating cold and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0052] Below in conjunction with embodiment and attached Figure 1~3 The present invention is described in further detail.

[0053] The following examples are only used to illustrate the present invention, but not to limit the present invention in any way.

[0054] Table 1

[0055]

[0056] Table 2

[0057]

[0058]

[0059] table 3

[0060]

[0061]

[0062] The weights described in Examples 1-9 were prepared as follows:

[0063] 1. Sustained-release dosage form: Weigh the pharmacologically active components, matrix materials, and pharmaceutical additives of the sustained-release dosage form, grind them separately, pass through an 80-mesh sieve, mix well, and add conventional solvents for the sustained-release dosage form to make a soft material , use a 16-mesh sieve to granulate, dry the wet granules at 40-50°C for 2-3 hours, until the water content is below 2%, granulate with a 14-mesh sieve, add the sieved lubricant, mix well, and calculate the tablet we...

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PUM

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Abstract

The invention relates to a compound preparation for treating cold and a preparation method thereof, belonging to the technical field of medicines. The compound preparation contains a sustained-releasedosage form prepared by respectively selecting an ingredient from an adrenomimetic drug and an antipyretic-analgesic and anti-inflammatory drug, and a fast-release membranous layer formed by any ingredient of an antihistamine drug, wherein the membranous layer is coated on the sustained-release dosage form, the antihistamine drug has fast effect and long time of drug effect, better treating effect can be achieved by fast release of the fast-release membranous layer, and simultaneously, the constant drug level of the adrenomimetic drug and the antipyretic-analgesic and anti-inflammatory drug is maintained in blood by sustained-release releasing. Therefore, the compound preparation can overcome the symptoms related to the cold, including the symptoms of nasal obstruction, sneeze, nasal bleeding, sputum itching, lacrimation and the like with pain and fever.

Description

technical field [0001] The invention relates to a medicinal compound preparation and a preparation method thereof, in particular to a medicinal compound preparation for treating colds and a preparation method thereof, belonging to the technical field of medicines. Background technique [0002] Influenza is the most common multiple disease of human beings, and it is a respiratory infectious disease that seriously endangers human health. According to statistics, adults suffer from 3 to 4 colds per year, and children have as many as 6 or more. The clinical manifestations of influenza can be divided into simple type, pneumonia type, poisoning type and gastrointestinal type, and can cause various complications. , the hazard is serious. [0003] my country is a cold-prone area, and there are outbreaks or epidemics in some areas almost every year, and its incidence rate ranks first in infectious diseases. Influenza viruses are easy to mutate and form new strains, which brings gre...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61K47/38A61K31/4545A61K31/335A61P29/00A61P11/02A61K31/137A61K31/167A61K31/192
Inventor 张建立曹相林王冬梅
Owner BEIJING SIHUAN KEBAO PHARM CO LTD
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