Concentrated freeze-dried yolk antibody composite preparation for infectious bursal disease and preparation process thereof

A technology for bursal disease and chicken infectivity, applied in the direction of antibodies, antiviral agents, allergic diseases, etc., can solve the problems of difficult implementation, high price, and difficult clinical wide acceptance, etc., and achieve long-lasting and effective prevention and control effects , good therapeutic effect

Active Publication Date: 2010-04-07
LIAONING YIKANG BIOLOGICAL CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] For example, interferon, cytokines, etc., are difficult to be widely accepted clinically due to their high price, and it is even more difficult to implement them in chicken infectious bursal disease

Method used

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  • Concentrated freeze-dried yolk antibody composite preparation for infectious bursal disease and preparation process thereof
  • Concentrated freeze-dried yolk antibody composite preparation for infectious bursal disease and preparation process thereof
  • Concentrated freeze-dried yolk antibody composite preparation for infectious bursal disease and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0094] Example 1. Multi-flavored Chinese medicine polysaccharide type chicken infectious bursal disease concentrated freeze-dried egg yolk antibody compound preparation

[0095] 1. Ingredients:

[0096] Anti-Avian Infectious Bursal Disease Virus Yolk Antibody 99.5 kg

[0097] Chinese medicine polysaccharide 0.5 kg

[0098] The Chinese medicinal polysaccharide is extracted from the Chinese medicinal composition in the following weight ratios: Angelica 10, Codonopsis 50, Astragalus 50, and Poria 30.

[0099] 2. Preparation:

[0100] (1) Preparation of highly immune eggs resistant to chicken infectious bursal disease virus.

[0101] (1.1) Laying hens free of specific pathogens are kept in isolation in clean farms;

[0102] (1.2) Carry out 3 immunizations to laying hens, each time each chicken is injected with infectious bursal disease vaccine, the injection volume is 0.5ml, 1.5ml and 2.0ml, each time is one week apart;

[0103] (1.3) 21 days after completing the third immunization, collect the...

Embodiment 2

[0135] Example 2. Three traditional Chinese medicine polysaccharide type chicken infectious bursal disease concentrated freeze-dried egg yolk antibody compound preparation

[0136] 1. Ingredients:

[0137] 65 kg of egg yolk antibody against infectious bursal disease virus;

[0138] 6 kg of polysaccharides from Chinese medicine;

[0139] 10 kg of sucrose;

[0140] 2. Preparation:

[0141] The preparation method of egg yolk antibody and polysaccharide is the same as in Example 1, except that the extraction source of polysaccharide is changed to the following parts by weight of Chinese medicine raw materials: 10 parts of Angelica sinensis, 20 parts of Codonopsis, and 10 parts of Poria;

[0142] The synthesis process and method of the compound preparation are the same as in Example 1, except that the synthetic raw materials become 65 kg of anti-avian bursal disease virus egg yolk antibody, 6 kg of polysaccharides and 10 kg of sucrose.

[0143] 3. Quality standards:

[0144] The same as in Examp...

Embodiment 3

[0145] Example 3. Two-flavor traditional Chinese medicine polysaccharide type chicken infectious bursal disease concentrated freeze-dried egg yolk antibody compound preparation

[0146] 1. Ingredients:

[0147] 40 kg of yolk antibody against chicken infectious bursal disease virus;

[0148] 20 kg of polysaccharides;

[0149] 6 kg of skimmed milk powder;

[0150] 2. Preparation:

[0151] The preparation method of egg yolk antibody and polysaccharide is the same as in Example 1, except that the extraction source of polysaccharide is changed to the following raw materials of traditional Chinese medicine by weight: 10 parts of Poria and 30 parts of Astragalus;

[0152] The synthesis process and method of the composite preparation are the same as in Example 1, except that the synthetic raw materials become 40 kg of anti-avian bursal disease virus egg yolk antibody, 20 kg of polysaccharides and 6 kg of skimmed milk powder.

[0153] 3. Quality standards:

[0154] The same as in Example 1.

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Abstract

The invention provides a concentrated freeze-dried yolk antibody composite preparation for infectious bursal disease, which contains the following components in part by weight: 10.0 to 99.5 parts of infectious bursal disease virus resistant yolk antibody and 0.5 to 20.0 parts of Chinese medicinal polysaccharide, wherein the Chinese medicinal polysaccharide is extracted from one or a composition of more than two of the following Chinese medicines in part by weight: 10 to 50 parts of Chinese angelica, 50 to 100 parts of szechwon tangshen root, 50 to 80 parts of membranous milkvetch root and 30 to 50 parts of Indian buead. The preparation is a freeze-dried preparation prepared by combining the components such as the infectious bursal disease virus resistant yolk antibody and the polysaccharide under the guidance of immunity engineering of Chinese medical science, is clinically used for the infectious bursal disease, has the effect of treating infectious bursal disease virus infection, and excites the immunity and disease resistance of organisms; and simultaneously, the polysaccharide component in the preparation has powerful protection effect on the yolk antibody.

Description

Technical field [0001] The invention relates to an antibody compound preparation, in particular to a concentrated freeze-dried egg yolk antibody compound preparation for chicken infectious bursal disease, and a preparation method thereof. Background technique [0002] Chicken infectious bursal disease is the enemy of the chicken industry. Anti-infective drugs currently used in the prevention and treatment of infectious bursal disease in chickens include antibiotics, chemically synthesized drugs, Chinese medicines and their preparations, high immune yolk antibodies and other anti-infective biological agents. [0003] (1) Antibiotics [0004] Such anti-infective drugs are mainly metabolites produced by microorganisms such as bacteria, fungi, and actinomycetes, as well as artificial synthetic or semi-synthetic antibiotics. They have strong inhibitory or killing effect on pathogenic microorganisms, broad antibacterial spectrum and good curative effect. They are mainly used to assist in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/395A61P31/14A61P37/04C08B37/00C07K16/10A61K31/715
Inventor 李尚波苗玉和胥桂华张勇飞赵冰武洁梅
Owner LIAONING YIKANG BIOLOGICAL CORP LTD
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