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Medicinal composition for treating cardio-cerebrovascular diseases

A technology for cardiovascular and cerebrovascular diseases and compositions, applied in the field of pharmaceutical compositions, can solve problems such as reperfusion injury, thrombolysis-reperfusion injury, and unsatisfactory curative effect, so as to reduce toxicity and increase cardio-cerebral Blood flow, the effect of improving the therapeutic effect

Inactive Publication Date: 2010-05-19
ZHEJIANG ACAD OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] For the causes of cardiovascular and cerebrovascular diseases, the existing treatment methods are mainly thrombolytic therapy and brain protection therapy. However, while thrombus dissolves and blood flow in tissues and organs is restored, reperfusion injury will occur to varying degrees, leading to more serious s consequence
At present, the commonly used western medicine preparations are mainly anticoagulant preparations (represented by aspirin) and fibrinolytic preparations (such as various fibrinolytic enzymes, urokinase, t-PA, etc.). The disease has a certain curative effect, but it only has a good curative effect on fresh thrombus, and the curative effect on old thrombus, especially those with sequelae, is not very satisfactory, and neither of them can solve the reperfusion injury caused by thrombolysis at the same time.

Method used

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  • Medicinal composition for treating cardio-cerebrovascular diseases
  • Medicinal composition for treating cardio-cerebrovascular diseases
  • Medicinal composition for treating cardio-cerebrovascular diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～6

[0023] The dried ginkgo leaves are crushed and extracted with ethanol, the extract is recovered from ethanol and concentrated, then added to a macroporous adsorption resin column soaked in ethanol, eluted with water and ethanol in sequence, the ethanol eluate is collected, ethanol is recovered, and dried , that is, Ginkgo biloba extract. After testing, the weight percent content of total flavonoids in the ginkgo leaf extract is 26%, the weight percent content of total bilobalactones is 6.5%, and the weight percent content of total ginkgolic acid is 5ppm.

[0024] Take Panax notoginseng, add ethanol, reflux and extract 3 times, 2 hours each time, recover the ethanol from the extract until it has no ethanol smell, add water until each ml is equivalent to 2 grams of the original medicinal material, refrigerate for 24 hours, filter, and add the filtrate to the used Soak in ethanol on the macroporous adsorption resin column. The treatment process is to soak in ethanol for 48 hours,...

Embodiment 1

[0040] Example 1 group: take the pharmaceutical composition prepared in Example 1, set up a dosage group of 15 mg / kg according to the dosage of SD rats;

Embodiment 2

[0041] Example 2 group: take the pharmaceutical composition prepared in Example 2, set up a dosage group of 15 mg / kg according to the dosage of SD rats;

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Abstract

The invention discloses a medicinal composition for treating cardio-cerebrovascular diseases, which comprises the following raw materials in percentage by weight: 0.1 to 99.8 percent of ginkgo biloba P.E; 0.1 to 99.8 percent of sanchi extract; and 0.1 to 99.8 percent of aspirin. By utilizing the synergistic action of the ginkgo biloba P.E, the sanchi extract and the aspirin, the medicinal composition can effectively improve cardio-cerebrovascular circulation after the cerebral infarction and the miocardial infarction, dilate cardiac and cerebral vessels, and increase cardio-cerebral blood flow volume, and also can effectively improve microcirculation and reduce damage caused by ischemia-reperfusion after the cerebral infarction and the miocardial infarction.

Description

technical field [0001] The invention relates to the field of pharmaceutical compositions, in particular to a pharmaceutical composition for treating cardiovascular and cerebrovascular diseases. Background technique [0002] Cardiovascular and cerebrovascular diseases refer to diseases with cerebral ischemic injury symptoms as the main clinical manifestation caused by cerebral blood vessel rupture, bleeding or thrombus formation, also known as cerebrovascular accident or stroke, commonly known as cerebral apoplexy. The disease is common in the acute attack of middle-aged people, and 70% to 80% of the patients are due to cerebral arteriosclerosis and other reasons that narrow the lumen of the cerebral artery, reduce or completely block the blood flow, hinder the blood circulation in the brain, and damage the brain tissue. A series of symptoms (such as ischemic cerebrovascular disease) caused by the injury, and severe cases may cause disturbance of consciousness and limb paraly...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61P9/10A61P7/02A61K31/616
Inventor 蔡钟钦
Owner ZHEJIANG ACAD OF TRADITIONAL CHINESE MEDICINE
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