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Red porcelain mold for preparing micropin and preparation method thereof

A mold and purple sand technology, applied in the field of medical equipment, can solve the problems of poor hydrophilicity and air permeability, difficult polymer solution, soft mold hardness, etc., and achieve the effect of easy operation, convenient purchase and low price

Inactive Publication Date: 2011-02-16
SHANGHAI JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

PDMS is a good molding material that can be used to prepare microporous molds, but the disadvantage of this technology is that the microporous array must be matched with the needle mold first, and the hardness of the mold is relatively soft and easy to deform. From a physical and chemical point of view, hydrophilicity and air permeability are not good, and it is not easy to use the method of suction filtration for polymer solutions

Method used

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  • Red porcelain mold for preparing micropin and preparation method thereof
  • Red porcelain mold for preparing micropin and preparation method thereof
  • Red porcelain mold for preparing micropin and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Embodiment 1: Preparation of microneedle mold by piercing method

[0046] Spread the purple sand mud on a glass plate (wooden, iron, zinc, steel, slate, or copper), and use another glass (wooden, iron, zinc, steel, slate, or copper) to press it lightly Form into 1cm thick smooth purple clay sheet, place it at room temperature to air dry for 15min, use a pin (its shape is cylindrical, conical, elliptical conical, tetrahedral conical, hexagonal conical, polygonal pyramid, any other polygonal shape or Several kinds) punch holes to make the expected array. After air-drying, it can be used by calcining in a muffle furnace. The calcination procedures of purple clay tablets of different sizes are shown in Table 1.

[0047] Table 1. Calcination procedures for purple clay tablets of different sizes

[0048]

[0049]

Embodiment 2

[0050] Embodiment 2: The purple sand mold of microneedle is prepared by hole grid method

[0051]Spread the purple clay on a glass plate (wooden, iron, zinc, steel, slate, or copper), and press it lightly with another glass plate (wooden, iron, zinc, steel, slate, or copper) Make a smooth purple clay sheet with a thickness of 1cm, spread the steel wire gauze on the purple clay sheet, and lightly press it with a glass sheet (wood, iron, zinc, steel, stone, or copper plate) to make the steel wire gauze and the surface of the purple clay sheet completely fit , using pins (the shape of which is cylindrical, conical, elliptical conical, tetrahedral conical, hexagonal pyramidal, polygonal pyramidal, any one or several other polygonal shapes) to pierce holes through the steel wire mesh, every Pull out the second time just until the steel wire catches the embroidery needle without deformation, and then pierce another hole until the expected array is completed. Then gently peel off th...

Embodiment 3

[0054] Embodiment 3: The purple sand mold of microneedle is prepared by yin and yang mold method

[0055] Several (≥3) porogens are fixedly arranged into a needle array with an area of ​​5cm*5cm, and an isolation layer is placed on the needle array to adjust the micropore depth to 0.8mm. Put the purple sand mud on the isolation layer and extrude it to completely fit the needle array, and after fixing for 4 hours, peel off the purple sand mud from the needle array and let it dry naturally or freeze-dry at room temperature to obtain a mold blank. After the air-dried mold blank is calcined, a purple sand mold for preparing microneedles is obtained. The thickness and calcination procedure of the mold blank are shown in Table 3.

[0056] Table 3. Thickness and calcination procedure of mold blank

[0057] Die blank thickness (cm)

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Abstract

The invention relates to a red porcelain mold for preparing a micropin and a preparation method thereof, and belongs to the technical field of medical appliances. The red porcelain mold is an array composed of a plurality of micropores, and the diameter of the micropore opening is 0.1-1 mm; the depth of the pore bottom is 0.3-3 mm; and the pore bottom can be in the structure of one or several of cylinder, tetrahedron cone, cone, hexagonal pyramid or other polygonal pyramids. The preparation materials used in the invention can be purchased conveniently and is low in price, all the involved instruments are daily necessities, thus, the invention is easy to realize in a common laboratory or workshop. The technique of the invention is simple and easy to operate; and the prepared mold can be used for preparing micropins by a centrifugal method and a suction filtration method.

Description

technical field [0001] The invention relates to a mold in the technical field of medical devices and a preparation method thereof, in particular to a purple sand mold for preparing microneedles and a preparation method thereof. Background technique [0002] The transdermal absorption of drugs is considered to be an effective drug delivery method to eliminate the pain caused by injection, but ordinary transdermal drug delivery often encounters barriers to the skin epidermis and stratum corneum and cannot meet the requirements. The appearance of microneedles solves the problem. solved this problem. The biggest advantage of microneedle transdermal technology is that it can pierce the biggest obstacle to drug absorption-the epidermis and its stratum corneum without hurting the dermis and nerves. The puncture of the epidermis by microneedling does not cause pain, and even the minimal trauma to the epidermis is that the reversible deformation of the skin is greater than the traum...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B28B1/48C04B33/00
Inventor 金拓尹忠袁伟恩杨泗兴
Owner SHANGHAI JIAOTONG UNIV
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