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Optical measurement method for molecular detection using relaxation measurement in optically anisotropic nanoparticles

An optical anisotropy, nanoparticle technology, applied in material analysis by optical means, nanotechnology for materials and surface science, nanotechnology for sensing, etc., can solve problems such as protein can not be

Inactive Publication Date: 2015-04-01
AIT AUSTRIAN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Of course, the application of molecular beacons is limited to the detection of relatively short DNA and RNA strands, i.e. proteins, for example, cannot be detected in this way

Method used

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  • Optical measurement method for molecular detection using relaxation measurement in optically anisotropic nanoparticles
  • Optical measurement method for molecular detection using relaxation measurement in optically anisotropic nanoparticles
  • Optical measurement method for molecular detection using relaxation measurement in optically anisotropic nanoparticles

Examples

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Embodiment Construction

[0063] All possible measuring configurations have in common that by means of any light source 1 a parallel light beam 2 is generated which is deflected towards the measuring unit 5 . In this case, the light source 1 can be not only monochromatic, ie, for example a laser, but also polychromatic, ie, for example an incandescent lamp, which emits polarized or unpolarized light.

[0064] The measuring cell 5 comprises a solution which, besides additional substances, contains target molecules to be analyzed and optically anisotropic nanoparticles 62 . The optical anisotropy axis of the nanoparticles can be oriented by an external stimulus, i.e. in particular by a field, which is generated by a suitable electromagnetic field generating device 6, the field 61 of which can vary in amplitude and / or Change in direction.

[0065] By means of at least one polarizer 3 and / or analyzer 4, at least one preferred direction is defined, relative to which the optical anisotropy induced by the na...

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Abstract

The method involves utilizing suspension and / or dispersion of a micro- or nano particle for relaxation behavior-determination, where the micro- or nano particle has an optical anisotropy. Linear, polarized and non polarized light is radiated in the suspension and / or the dispersion. The light that is either emitted by stimulation or directly received in a radiation-direction by absorption from the suspension and / or the dispersion is subjected to an Opto-metric analysis. An independent claim is also included for a device for executing a method for molecular detection of micro- or nano particle.

Description

technical field [0001] The present invention relates to a novel detection method in a molecular detection method in which the target molecule to be detected is specifically bound (anbinden) to nanoparticles suspended in a suitable solution and correspondingly functioning On the surface. The hydrodynamic diameter of the particle is enlarged by this connection. If the particle orientation is now changed by an external stimulus, the expansion of the hydrodynamic diameter leads to altered Brownian relaxation properties of the nanoparticles. The measurement of this relaxation property thus allows the quantification of the concentration of target molecules located in solution. Background technique [0002] In order to determine the molecular occupancy (Molekuelbelegung) of nanoparticles, the measurement of the relaxation properties was first published by Weitschies at al. in document WO96 / 23227A1, which describes ferromagnetic or ferromagnetic nanoparticles whose magnetic moment...

Claims

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Application Information

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IPC IPC(8): G01N33/543G01N21/17
CPCG01N2021/258G01N33/54346G01N21/1717B82Y15/00B82Y30/00
Inventor H·布鲁克尔J·肖特O·贝思格
Owner AIT AUSTRIAN INST OF TECH
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