Medicinal composition for treating bacterial vaginitis
A vaginitis and composition technology, applied in the field of pharmaceutical preparations, can solve problems such as inability to guarantee the curative effect, frequent medication times, and medication time limitations, and achieve the effects of improving medication compliance, reducing medication times, and ensuring effective treatment.
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Embodiment 1
[0051] Prescription composition:
[0052] Clindamycin Phosphate 2%
[0053] Belosham F127 15%
[0054] Carbomer 934 0.5%
[0055] Hypromellose K4M 1.5%
[0056] Methylparaben 0.15%
[0057] Propylparaben 0.05%
[0058] Edetate Disodium 0.01%
[0059] water balance.
[0060] Preparation:
[0061] Take clindamycin phosphate, methylparaben, propylparaben and edetate disodium, add water to dissolve and stir evenly, add poloxamer, carbomer and hypromellose while stirring , place it at 4°C, keep stirring, and after fully swollen, use 1mol / l NaOH solution and 1mol / l HCl solution to adjust the pH to 3-7, and distribute it in the vaginal applicator, 5g each, that is have to.
Embodiment 2
[0063] Prescription composition:
[0064] Clindamycin Phosphate 1%
[0065] Beloxamer F68 5%
[0066] Hypromellose K4M 8%
[0067] Methylparaben 0.1%
[0068] Propylparaben 0.1%
[0069] Edetate Disodium 0.05%
[0070] Apple Flavor 0.01%
[0071] water balance.
[0072] Preparation:
[0073] Take clindamycin phosphate, methylparaben, propylparaben, apple essence and edetate disodium, add water to dissolve and stir evenly, add poloxamer and hypromellose while stirring, Keep stirring, and after fully swollen, use 1mol / l NaOH solution and 1mol / l HCl solution to adjust the pH to 3-7, dispense it into vaginal applicators, 5g each, and get ready.
Embodiment 3
[0075] Prescription composition:
[0076] Clindamycin Phosphate 1%
[0077] Belosham F68 31%
[0078] Sodium Carboxymethyl Cellulose 2%
[0079] Methylparaben 0.2%
[0080] Edetate disodium 0.1%
[0081] Peach flavor 0.01%
[0082] water balance.
[0083] Preparation:
[0084] Take clindamycin phosphate, methylparaben, peach essence and disodium edetate, add water and stir to dissolve, add poloxamer and sodium carboxymethylcellulose while stirring, and place at 4°C , after being fully dispersed, adjust the pH to 3-7 with 1mol / l NaOH solution and 1mol / l HCl solution, and pack them into vaginal applicators, 10g each, to get ready.
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