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Medicinal composition for treating bacterial vaginitis

A technology for vaginitis and composition, applied in the field of pharmaceutical preparations, can solve the problems of inability to guarantee curative effect, time limit for medication, vaginal irritation and side effects, and achieve the effects of improving medication compliance, ensuring effective treatment, and prolonging contact time.

Active Publication Date: 2012-05-23
SHENZHEN SOUTH CHINA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] 1) easy to leak
After the common preparation is used, it is easy to leak out under the action of vaginal secretions and excretions. On the one hand, the drug will be lost and the curative effect cannot be guaranteed. On the other hand, it will bring great inconvenience to the patient and reduce the compliance of the patient;
[0007] 2) frequent use of medication
Due to the problems of leakage and fast drug release, the drug has a short action time in the vagina and low curative effect, so in most cases, it needs to be used once a day for more than 7 consecutive days, and the frequency of administration is frequent;
[0008] 3) It is easy to cause vaginal irritation and side effects
Because most of the drug is leaked, it needs to be used repeatedly, and the dosage is large, often causing vaginal irritation and side effects
[0009] 4) Medication time is limited

Method used

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  • Medicinal composition for treating bacterial vaginitis
  • Medicinal composition for treating bacterial vaginitis
  • Medicinal composition for treating bacterial vaginitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Prescription composition:

[0052] Clindamycin Phosphate 2%

[0053] Belosham F127 15%

[0054] Carbomer 934 0.5%

[0055] Hypromellose K4M 1.5%

[0056] Methylparaben 0.15%

[0057] Propylparaben 0.05%

[0058] Edetate Disodium 0.01%

[0059] water balance.

[0060] Preparation:

[0061]Take clindamycin phosphate, methylparaben, propylparaben and edetate disodium, add water to dissolve and stir evenly, add poloxamer, carbomer and hypromellose while stirring , place it at 4°C, keep stirring, and after fully swollen, use 1mol / l NaOH solution and 1mol / l HCl solution to adjust the pH to 3-7, and distribute it in the vaginal applicator, 5g each, that is have to.

Embodiment 2

[0063] Prescription composition:

[0064] Clindamycin Phosphate 1%

[0065] Beloxamer F68 5%

[0066] Hypromellose K4M 8%

[0067] Methylparaben 0.1%

[0068] Propylparaben 0.1%

[0069] Edetate Disodium 0.05%

[0070] Apple Flavor 0.01%

[0071] water balance.

[0072] Preparation:

[0073] Take clindamycin phosphate, methylparaben, propylparaben, apple essence and edetate disodium, add water to dissolve and stir evenly, add poloxamer and hypromellose while stirring, Keep stirring, and after fully swollen, use 1mol / l NaOH solution and 1mol / l HCl solution to adjust the pH to 3-7, dispense it into vaginal applicators, 5g each, and get ready.

Embodiment 3

[0075] Prescription composition:

[0076] Clindamycin Phosphate 1%

[0077] Belosham F68 31%

[0078] Sodium Carboxymethyl Cellulose 2%

[0079] Methylparaben 0.2%

[0080] Edetate disodium 0.1%

[0081] Peach flavor 0.01%

[0082] water balance.

[0083] Preparation:

[0084] Take clindamycin phosphate, methylparaben, peach essence and disodium edetate, add water and stir to dissolve, add poloxamer and sodium carboxymethylcellulose while stirring, and place at 4°C , after being fully dispersed, adjust the pH to 3-7 with 1mol / l NaOH solution and 1mol / l HCl solution, and pack them into vaginal applicators, 10g each, to get ready.

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PUM

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Abstract

The invention relates to a medicinal composition for treating bacterial vaginitis, which comprises main medicaments, substrates, a bioadhesive material, a release rate regulator and other additives. The medicinal composition for treating bacterial vaginitis has specific biological adhesion, keeps longer time, reduces leakage of the medicaments, prolongs the contact time of the medicaments and thevagina mucosa, and guarantees the curative effect. The composition has specific vagina slow release performance, and can continuously release the medicaments for 2 to 7 days. Compared with the commonpreparation, the medicinal composition prolongs the releasing time of the medicaments, can reduce the administration times, and is convenient for the patient to take. As simultaneously the medicinal composition has the characteristics of biological adhesion and slowly-released long effect, the medicinal composition has no requirement for the administration time, and the administration can be carried out at any time.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a pharmaceutical composition for treating bacterial vaginosis. Background technique [0002] Gynecological inflammation is a common disease in women. About 87% of adult women in the world have been infected with gynecological inflammation to varying degrees. Common clinical gynecological inflammations include vaginitis, cervicitis, pelvic inflammatory disease, endometritis, etc. Among them, the incidence of vaginitis The highest, accounting for about one-third of gynecological inflammation. [0003] Vaginitis mainly includes three types, namely fungal vaginitis, bacterial vaginosis and trichomonas vaginitis, among which bacterial vaginosis and fungal vaginitis have the highest incidence rate, and these two kinds of vaginitis are widely distributed in different countries and regions. The incidence rate is different, the incidence rate of bacterial vaginosis is...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7056A61P15/02
Inventor 杨书华禇志杰王栋巩洪刚常建晖邓树海
Owner SHENZHEN SOUTH CHINA PHARMA
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