Medicine composite for treating vaginitis
A composition and vaginitis technology, applied in the field of pharmaceutical preparations, can solve the problems of affecting the curative effect, easy leakage, low curative effect, etc., and achieve the effects of improving drug compliance, prolonging contact time, and prolonging release time
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[0072] Example 1.
[0073] Composition of prescription:
[0074] Butoconazole nitrate 2%
[0075] Poloxamer F127 17%
[0076] Carbomer 934 0.5%
[0077] Hypromellose K4M 1.5%
[0078] Methyl Paraben 0.15%
[0079] Water balance
[0080] Preparation:
[0081] Take methyl paraben, add water to dissolve and stir evenly, while stirring, add poloxamer, carbomer, hypromellose, and place it at 4°C. After it is fully dissolved, add the 200 mesh sieve Stir the butoconazole nitrate evenly, distribute it into the vaginal applicator, and get 5g each.
Example Embodiment
[0082] Example 2.
[0083] Composition of prescription:
[0084] Butoconazole nitrate 100mg
[0085] Hypromellose K4M 400mg
[0086] Carbomer 947 100mg
[0087] Polyethylene glycol 4000 200mg
[0088] Preparation:
[0089] 1. Take butoconazole nitrate through a 200-mesh sieve, hypromellose, polyethylene glycol and carbomer respectively through an 80-mesh sieve, mix well, add 80% ethanol solution to make a suitable softener, and go through an 18-mesh sieve Prepare granules and dry them at 40~50℃ to obtain dry granules;
[0090] 2. The dry granules are sieved through a 20-mesh sieve, and talc powder (added at 1% of the total granules) is added as a glidant and lubricant, mixed well, and the granule content is determined;
[0091] 3. Compress tablets, each containing 100mg of butoconazole nitrate, and pack it immediately.
Example Embodiment
[0092] Example 3.
[0093] Composition of prescription:
[0094] Butoconazole nitrate 1%
[0095] Hydroxypropyl beta cyclodextrin 40%
[0096] Poloxamer F127 17%
[0097] Hypromellose K4M 2%
[0098] Methyl paraben 0.5%
[0099] Propylparaben 0.5%
[0100] Disodium edetate 0.01%
[0101] Water margin.
[0102] Preparation:
[0103] Take butoconazole nitrate and hydroxypropyl beta cyclodextrin, add water and continue stirring to dissolve, add disodium edetate, methyl paraben and propyl paraben, stir to dissolve, add poloxat while stirring Hypromellose and hypromellose are placed at 4°C. After they are fully dispersed, they are divided into a vaginal applicator, 10g each, ready to be obtained.
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