Trisubstituted chiral lactam derivative and preparation method and application thereof

A lactam and substituent technology, applied in the field of tri-substituted chiral γ-lactam derivatives, can solve the problems of ineffectiveness of disease development and potential safety hazards.
CN101747253AInactive Publication Date: 2010-06-23INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A +1
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
Publication Date
2010-06-23
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a trisubstituted chiral lactam derivative with the antagonistic effect of a CCR4 shown in a general formula I. The definition of each substituent group in a general formula I is shown as a specification. The invention also relates to a preparation method of a compound shown in the general formula I, a medicament composition containing the compound in the general formula Iand an application of the compound in the general formula I in the preparation of medicaments. The medicaments are used for treating and preventing diseases related to the CCR4.
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Description

technical field

[0001] The present invention relates to novel trisubstituted chiral γ-lactam derivatives capable of antagonizing human chemokine receptor 4 (abbreviated as hCCR4), the preparation method of these compounds, the pharmaceutical composition containing the above compounds, and the use of the compounds Use in the preparation of medicines for treating and / or preventing hCCR4-mediated diseases or conditions. technical background

[0002] CCR4 (Chemokine Receptor 4, Chemokine Receptor 4) was first discovered by Christine A.Power et al. in 1995 (Christine AP et al. J.Biol.Chem.1995, 270(8):19495-19500), which belongs to chemotaxis One of the members of the factor receptor (CCR) family, it is a 7-transmembrane G-protein coupled receptor. It has two naturally occurring specific ligands: MDC (Macrophage-derived chemokine) and TARC (thymus and activation regulated chemokine) (Sadatoshi Maeda et al. Veterinary Immunology and Immunopathology 2002(90): 145-154). The newly ...

Claims

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