Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Intradermal influenza vaccine

A technology of influenza vaccine and influenza, which is applied in the field of infectious diseases and drugs, and can solve the problems of non-use

Active Publication Date: 2010-06-23
CRUCELL SWITZERLAND AG
View PDF15 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, aluminum is not usually used in flu vaccines due to adverse side effects such as pain at the injection site

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Intradermal influenza vaccine
  • Intradermal influenza vaccine
  • Intradermal influenza vaccine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Embodiment 1

[0048] In another preferred embodiment, the vaccine comprises 1-10 μg of HA antigen from a single strain (or from each of the 3 influenza strains in the case of a trivalent vaccine), eg about 3.0 μg. In a more preferred embodiment, the virion-based influenza vaccine is Berna Biotech AG under the trademark V vaccine commercialized vaccine. Preferably, the invention relates to a method according to the invention, wherein the vaccine does not contain HA from influenza strains A / New Caledonia / 20 / 99, A / Moscow / 10 / 99 and B / Hong Kong / 330 / 2001 Trivalent combination of antigens. As indicated herein, administration is preferably performed using a delivery device suitable for intradermal delivery of the vaccine. A device suitable for intradermal delivery may be a single hypodermic needle. It was found that some devices were prepared so that the needle could not pass through the cortex, which would result in sub-optimal intradermal delivery. In other words, some devices contain relati...

Embodiment 2

[0051] These studies showed that when virion-based influenza vaccines were administered intradermally to humans at a concentration of 3 μg of each strain (two A strains and one B strain), seroconversion and GMT criteria were positive for all three strains. is met, and the seroprotection rate of at least two A strains is met. This is very unexpected and in stark contrast to what was disclosed in WO2004 / 016281, where it was shown that this type of vaccination did not meet the standards set by the authorities for any of the three strains used therein. Example 2. Dose Escalation (and Intramuscular vs. Intradermal) Studies with Virosome-Based Influenza Vaccines in Human Individuals

[0052] A second clinical study involving human subjects was conducted to evaluate the humoral immune response to an intradermally administered seasonal virion-adjuvanted influenza vaccine. This included a single-center, randomized dose-escalation study in which a volume of 0.1 mL of trivalent V Infl...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to virosome-based influenza vaccines for the manufacture of medicaments that are administered intradermally in humans. The invention provides (trivalent) compositions comprising low doses of hemagglutinin (HA) antigen in a virosomal preparation that fulfill the immune response standards with respect to seroconversion rates, GMT-fold increase and protection rates, for use in vaccination set-ups.

Description

field of invention [0001] The invention relates to the field of medicine, especially the field of infectious diseases. More specifically, the invention relates to the use of vaccines comprising virosomes in the manufacture of medicaments for the prophylactic treatment of influenza infections. Background of the invention [0002] Influenza viruses (members of the Orthomyxoviridae family) are the causative agents of annual epidemics of acute respiratory disease. Influenza epidemics and pandemics continue to claim human life and affect the global economy. In the U.S. alone, 50 million Americans get the flu each year. It is estimated that the number of deaths per year worldwide (1972-1992) is 60,000 (CDC statistics). In addition to seasonal epidemics, there have been three major influenza pandemics in the last century. A classic example of a severe influenza pandemic is the "Spanish Flu" of 1918-1919, which killed an estimated 40-50 million people worldwide. Other pandemics...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/145A61K9/127
CPCA61K9/0019A61K2039/54C12N2760/16123C12N7/00C12N2760/16134A61K39/295A61K2039/5258C12N2760/16234A61K39/145A61K39/12A61K2039/70A61P31/16A61K39/135A61K9/127
Inventor C·赫尔佐克H·拉扎尔
Owner CRUCELL SWITZERLAND AG
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com