The invention relates to the field of traditional Chinese medicine, in particular to a hepatitis B virus resistant traditional Chinese medicine composition composed of the following concrete components in parts: 15-20 parts of radix astragali, 12-15 parts of bupleurum, 12-15 parts of phellodendron bark, 6-12 parts of picrorhiza rhizome, 15-20 parts of giant knotweed, 15-20 parts of dyers woad leaf, 15-20 parts of asket fern, 12-15 parts of white atractylodes rhizome, 15-20 parts of tuckahoe, 15-20 parts of oldenlandia diffusa, 15-20 parts of red sage root and 5-8 parts of liquorice. The hepatitis B virus resistant traditional Chinese medicine composition can be prepared into capsules, decoction or extract, has the effects of clearing away heat and toxic material, strengthening the spleen and removing dampness through diuresis, has very strong efficacies of resisting hepatitis B virus, reducing HBVDNA (Hepatitis B Virus Deoxyribose Nucleic Acid) and promoting seroconversion of HBsAg (Hepatitis B Surface Antigen), and has multiple effects of protecting the liver, preventing pathological changes and the like.