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Liver-soothing lipid-lowing drug composition and preparation method thereof

A technology of composition and drug, applied in the field of pharmaceutical composition capable of soothing the liver and lowering lipid and its preparation, can solve the problem of lack of specific drug treatment for fatty liver

Active Publication Date: 2012-04-18
ZHEJIANG STRONG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Judging from various clinical reports, Western medicine still lacks specific drug treatment for fatty liver, but Chinese medicine, especially dehumidification, turbidity, and blood circulation and blood stasis drugs are effective.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Implementation 1. Capsules

[0064] Salvia 833g Alisma 833g Cassia 417g

[0065] Lotus leaf 417g Bupleurum 250g

[0066] (1) Take the above five flavors and add 8 times the amount of water to decoct 3 times, each time for 1 hour;

[0067] (2) Filtrate, combine the decoction, concentrate to a clear paste with a relative density of 1.10-1.14 (60°C), add ethanol to make the alcohol content reach 60%, and place overnight;

[0068] (3) Take the supernatant to recover ethanol, concentrate to an extract with a relative density of 1.14-1.20 (60°C), and spray dry;

[0069] (4) Add appropriate amount of β-cyclodextrin and magnesium stearate, mix well, dry press into granules, put into capsules, make 1000 granules, pack, and get ready.

Embodiment 2

[0070] Embodiment 2, capsule

[0071] Salvia 500g Alisma 500g Cassia 200g

[0072] Lotus leaf 200g Bupleurum 100g

[0073] (1) Take the above five flavors and add 8 times the amount of water to decoct 3 times, each time for 1 hour;

[0074] (2) Filtrate, combine the decoction, concentrate to a clear paste with a relative density of 1.10-1.14 (60°C), add ethanol to make the alcohol content reach 60%, and place overnight;

[0075] (3) Take the supernatant to recover ethanol, concentrate to an extract with a relative density of 1.14-1.20 (60°C), and spray dry;

[0076] (4) Add appropriate amount of β-cyclodextrin and magnesium stearate, mix well, dry press into granules, put into capsules, make 1000 granules, pack, and get ready.

Embodiment 3

[0077] Embodiment 3, capsule

[0078] Salvia 500g Alisma 500g Cassia 200g

[0079] Lotus leaf 200g Bupleurum 100g

[0080] (1) Take the above five flavors and add 6 times the amount of water to decoct 3 times, each time for 1 hour;

[0081] (2) Filtrate, combine the decoction, concentrate to a clear paste with a relative density of 1.10-1.14 (60°C), add ethanol to make the alcohol content reach 60%, and place overnight;

[0082] (3) Take the supernatant to recover ethanol, concentrate to an extract with a relative density of 1.14-1.20 (60°C), and spray dry;

[0083] (4) Add appropriate amount of β-cyclodextrin and magnesium stearate, mix well, dry press into granules, put into capsules, make 1000 granules, pack, and get ready.

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PUM

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Abstract

The invention relates to Chinese medicine field, in particular to a liver-soothing lipid-lowing drug composition and a preparation method thereof, wherein the drug composition is prepared through salvia miltiorrhiza, rhizome alismatis, semen cassiae, lotus leaf and radix bupleuri.

Description

Technical field: [0001] The invention relates to the field of traditional Chinese medicines, in particular to a pharmaceutical composition capable of soothing the liver and lowering lipids and a preparation method thereof. Background technique: [0002] Fatty liver (FL) is a pathological state of excessive fat accumulation in the liver caused by various reasons. When the lipid accumulation in the liver cells exceeds 5%, or when more than 1 / 3 of the liver cells per unit area is histologically fatty, it is called fatty liver. Although there is no special record of this disease in the literature of traditional Chinese medicine, according to its lesion characteristics, it generally belongs to the categories of "accumulation", "hypochondriac pain", "phlegm turbidity" and "blood stasis" in traditional Chinese medicine. [0003] In recent years, the incidence of fatty liver has been increasing year by year and tends to be younger. According to statistics from European and American...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/884A61K9/48A61P1/16
Inventor 王永新
Owner ZHEJIANG STRONG PHARMA CO LTD