Preparation method of acetone alcohol

A technology of acetol and propylene glycol, applied in chemical instruments and methods, oxidation preparation of carbonyl compounds, metal/metal oxide/metal hydroxide catalysts, etc., can solve the problems of difficult preparation, high price and high production cost

Inactive Publication Date: 2010-07-14
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The former has mild reaction conditions, low and simple synthesis or production equipment requirements, high product yield and high purity, but the price of the main raw material monobromoacetone leads to excessive production costs, which is the biggest shortcoming of the method; the latter has high requirements

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1 (catalyst preparation)

[0018] The preparation process of catalyst A is as follows: at room temperature, Mg(NO 3 ) 2 and K of 1.5mol / L 2 CO 3 Equal volumes of the solution were mixed, reacted, aged for 6 hours, filtered, and dried to obtain basic magnesium carbonate; the basic magnesium carbonate was placed in a muffle furnace and calcined at 550°C for 4 hours to obtain the MgO catalyst. N 2 The BET specific surface area measured by physical adsorption and desorption method is 58m 2 / g.

Embodiment 2

[0019] Embodiment 2 (catalyst preparation)

[0020] The preparation process of catalyst B is as follows: at 60°C, Mg(NO 3 ) 2 and K of 1.5mol / L 2 CO 3 Equal volumes of the solution were mixed, reacted, aged for 6 hours, filtered, and dried to obtain basic magnesium carbonate; the basic magnesium carbonate was placed in a muffle furnace and calcined at 550°C for 4 hours to obtain the MgO catalyst. N 2 The BET specific surface area measured by physical adsorption and desorption method is 110m 2 / g.

Embodiment 3

[0021] Embodiment 3 (catalyst preparation)

[0022] The preparation process of catalyst C is as follows: at 100°C, Mg(NO 3 ) 2 and K of 1.5mol / L 2 CO 3 Equal volumes of the solution were mixed, reacted, aged for 6 hours, filtered, and dried to obtain basic magnesium carbonate; the basic magnesium carbonate was placed in a muffle furnace and calcined at 550°C for 4 hours to obtain the MgO catalyst. N 2 The BET specific surface area measured by physical adsorption and desorption method is 150m 2 / g.

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Abstract

The invention relates to a method for preparing acetone alcohol by gas phase dehydrogenation of 1,2-propanediol. The method is used for generating the acetone alcohol by gas phase dehydrogenation of the 1,2-propanediol by using alkali-earth oxides as catalysts. The conversion per pass of the 1,2-propanediol is greater than 60%, and the selectivity of the acetone alcohol in products is greater than 90wt%. The method has the advantages of simple process, low cost and no pollution, and is an environment-friendly acetone alcohol production line.

Description

technical field [0001] The invention relates to a method for preparing acetol by using 1,2-propanediol as a raw material. Specifically, the alkaline earth metal oxide is used as a catalyst to catalyze the gas phase dehydrogenation of 1,2-propanediol to generate acetol. Background technique [0002] Acetol, also known as 1-hydroxy-2-propanone (hydroxyacetone) or acetylmethanol, is used to synthesize H in the digestive system 2 The intermediate 4-methylimidazole of the blocking drug cimetidine, the intermediate of the quinolone antibacterial drug levofloxacin (s)-(+)-2-aminopropanol, the intermediate of racemic histidine 4-Hydroxymethylimidazole, also used in biotin (vitamin H) and antipyretic and analgesic drugs such as aspirin acetonate and chiral intermediates (1)-(-)-1,2- Synthesis of Propylene Glycol. The synthetic method of acetol is mainly: monobromoacetone esterification / alcoholysis and 1,2-propanediol oxygen or K 2 CrO 7 / H 2 SO 4 Oxidation method, etc. The fo...

Claims

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Application Information

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IPC IPC(8): C07C49/17C07C45/27B01J23/02
Inventor 于政锡许磊刘中民张新志张世刚王莹利毕怡
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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