Liquid oral composition, and method for improvement in bactericidal activity of cationic bactericidal agent

Abstract

Disclosed is a liquid oral composition comprising: (A) cetylpyridinium chloride in an amount of 0.01 to 0.1 mass%; (B) sodium lauroylsarcosine in an amount of 0.02 to 0.3 mass%; and (C) a poly(oxyethylene) hydrogenated castor oil having an average molar number of ethylene oxide units added of 40 to 100 moles in such an amount that the [(A) / (B)] ratio becomes 0.3 to 3 by mass and the [(C) / ((A)+(B))] ratio becomes 1.0 to 20 by mass. The liquid oral composition enables the rapid penetration of a bactericidal agent into a cariogenic biofilm to exhibit an excellent bactericidal activity on a cariogenic bacterium, is reduced in the occurrence of lees or turbidness during the storage at a lower temperature, has good appearance stability, and is effective for the prevention of dental caries.

Description

technical field [0001] The present invention relates to a liquid composition for oral cavity and a method for improving bactericidal activity of a cationic bactericide, wherein the bactericide in the liquid composition for oral cavity effectively permeates into caries pathogenic biofilm in the oral cavity and exhibits excellent performance against caries pathogenic bacteria At the same time, the occurrence of precipitation and turbidity is suppressed during low-temperature storage, and the appearance stability is good. Background technique [0002] In the oral cavity, a biofilm formed by dental caries pathogenic bacteria such as Streptococcus mutans adheres to the tooth surface, and the tooth is demineralized (destroys the enamel) by the acid generated in the biofilm, resulting in dental caries. [0003] Therefore, as a means for preventing dental caries, in the field of liquid oral compositions, a means of killing dental caries pathogenic bacteria by mixing various bacteric...

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Problems solved by technology

[0004] However, although these cationic bactericides exert a good bactericidal effect on the planktonic bacteria in the oral cavity, they have the following problems: the ability to penetrate into the oral biofilm is weak, and in particular, they cannot fully exert their effect on caries-pathogenic bacteria in the oral biofilm. The bactericidal effect

[0007] However, even though these techniques are effective against peridental pathogenic biofilms, it is difficult to exert a sufficient bactericidal effect against dental caries pathogenic bacteria such as Streptococcus mutans in dental caries pathogenic biofilms.

[0008] In addition, Example 2 of Patent Document 9 and Example 10 of Patent Document 10 exemplify a mouthwash in which cetylpyridinium chloride and sodium palmitoyl sarcosinate are mixed with polyethylene oxide. The composition of alkanes hardened castor oil, but since the palmitoyl group of sodium palmitoyl sarcosinate has a large number of carbon atoms in this mouthwash, precipitation and turbidity occur during low-temperature storage, and it cannot be said that it does not ensure sufficient appearance stability.

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