Application of amitriptyline

A technology of amitriptyline and tripline, which is applied in the direction of medical preparations containing active ingredients, organic active ingredients, drug combinations, etc., can solve the problems that amitriptyline has not been reported in multiple myeloma, and achieve the purpose of inhibiting cell Effects of splitting, promoting apoptosis and inhibiting proliferation

Inactive Publication Date: 2010-07-21
SUZHOU UNIV
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0004] There is no report about the use of amitriptyline

Method used

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  • Application of amitriptyline
  • Application of amitriptyline
  • Application of amitriptyline

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Embodiment 1

[0038] The human myeloma cell line used in the present invention was provided by Dr. Aaron Schimmer, Ontario Cancer Institute, University of Toronto.

[0039] Specific implementation method:

[0040](1) Construction of antidepressant drug library: select all antidepressants from the small molecule chemical library LOPAC1280 (Sigma Company) and Prestwick (Prestwick Chemical Inc.) to form a library consisting of 28 antidepressant drugs including amitriptyline The library composed of drugs and related drugs includes: Alaproclate, Amitriptyline, Amoxapine, Bupropion, Citalopram, Clomipramine , Cyclobenzapine, Desipramine, Fluoxetine, Fluvoxamine, Imipramine, Indatraline, Ketoser Ketanserine, Maprotiline, Metergoline, Methiothepin, Methysergide, Mianserin, Nortriptyline, Piperazine, Pirenzepine, Protriptyline, Quipazine, Reserpine, Ritanserin, Trazodone, Trimipramine, Zimelidine, etc.

[0041] (2) Fluorescein analysis of the transcriptional activity of the cyclin D2 promoter: t...

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Abstract

The invention belongs to the field of tumor medicines, in particular to application of amitriptyline to the preparation of medicines for treating multiple myeloma. The amitriptyline can not only treat the depression of a patient, but also can effectively control the proliferation of myeloma cells and induce the apoptosis of the myeloma cells. Meanwhile, the amitriptyline inducing the apoptosis of the myeloma cells has synergistic effect with dexamethasone, the synergistic effect of the amitriptyline and the dexamethasone is improved by 20-30 percent compared with single molecule treatment.

Description

technical field [0001] The invention belongs to the field of tumor drugs, in particular to the application of amitriptyline in the preparation of drugs for treating multiple myeloma. Background technique [0002] Multiple myeloma is a type of malignant tumor with abnormal proliferation of plasma cells. A large number of proliferating myeloma cells often invade the bone, bone marrow, kidney, immune and other systems. Since there is no complete cure and medicine, the clinical mortality rate is 100%. Patients with multiple myeloma are often depressed, often accompanied by depression. Molecular and cytogenetic studies have found abnormal expression of cyclin D in multiple myeloma cells without exception. For example, cyclin D2 (Cyclin D2) is abnormally high expressed in more than 50% of myeloma cell lines and patients. This abnormality is related to the abnormality of the transcription factor c-maf of Cyclin D2, which is a molecular indicator of poor prognosis. In our previo...

Claims

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Application Information

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IPC IPC(8): A61K31/135A61K31/573A61P35/00
Inventor 毛新良
Owner SUZHOU UNIV
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