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Preparation method of sugar-free traditional Chinese medicine oral liquid for treating angina pectoris

A technology for coronary heart disease angina pectoris and traditional Chinese medicine oral liquid, which is applied in the field of medicine to achieve the effects of improving stability, good dispersion effect, prolonging drug efficacy and shelf life

Active Publication Date: 2010-07-21
LUNAN HOPE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to solve the sugar content in Xintong Oral Liquid and the adverse effects faced by some patients with coronary heart disease and angina pectoris while suffering from diabetes mellitus, the inventors improved the original specifications of the sugar-containing type through experimental research. Add sucrose for flavoring, use cyclodextrin inclusion technology for flavoring, develop sugar-free oral liquid specifications, realize the industrialization of inclusion technology in the production process of traditional Chinese medicine oral liquids, and overcome the limitations of traditional flavoring technology Insufficient, the taste of the preparation is improved, the compliance of patients with medication is improved, and the water solubility of the low-polarity active ingredient is increased through the formation of clathrates, and the quality stability of the preparation is improved, thereby realizing the present invention

Method used

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  • Preparation method of sugar-free traditional Chinese medicine oral liquid for treating angina pectoris
  • Preparation method of sugar-free traditional Chinese medicine oral liquid for treating angina pectoris
  • Preparation method of sugar-free traditional Chinese medicine oral liquid for treating angina pectoris

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Example 1: Preparation of sugar-free Xintong Oral Liquid

[0042] A extraction and concentration process:

[0043] 22 parts of kudzu root and 15 parts of danshen were reflux extracted twice with 8 times the amount of 70% ethanol, each time for 2 hours, and filtered to obtain the alcohol extract;

[0044] 22 parts of kudzu root, 15 parts of salvia miltiorrhiza after alcohol extraction, 26 parts of astragalus, 14 parts of codonopsis, 10 parts of radix radix, 8 parts of Polygonum multiflorum, 8 parts of epimedium, 8 parts of angelica, 8 parts of saponins, and 14 parts of seaweed 14 parts of kelp, 14 parts of oysters, 4 parts of Citrus aurantium, add 8 times the amount of water together, decoct 2 times, decoct for 2.0 hours respectively, combine the decoction liquid, filter, and the filtrate is concentrated under reduced pressure to a relative density of 1.20 (60 ℃) clear paste; combined with the alcohol extracts of Pueraria root and Salvia miltiorrhiza, add ethanol to mak...

Embodiment 2

[0047] Example 2: Preparation of sugar-free Xintong Oral Liquid

[0048] A extraction and concentration process:

[0049] 11 parts of kudzu root and 7 parts of salvia miltiorrhiza were extracted twice with 8 times the amount of 40% ethanol under reflux, each time for 2 hours, and filtered to obtain the alcohol extract;

[0050] 11 parts of kudzu root, 7 parts of salvia miltiorrhiza after alcohol extraction, 13 parts of astragalus, 7 parts of codonopsis, 5 parts of Ophiopogon japonicus, 4 parts of Polygonum multiflorum, 4 parts of epimedium, 4 parts of angelica, 4 parts of saponins, 7 parts of seaweed 7 parts of kelp, 7 parts of oyster, 2 parts of Citrus aurantium, add 8 times the amount of water together, decoct 2 times, decoct for 2.0 hours respectively, combine the decoction liquid, filter, and the filtrate is concentrated under reduced pressure to a relative density of 1.20 (60 ℃) clear cream; combined with the alcohol extracts of Pueraria root and Salvia miltiorrhiza, add...

Embodiment 3

[0053] Example 3: Preparation of Sugar-Free Xintong Oral Liquid

[0054] A extraction and concentration process:

[0055] 44 parts of kudzu root and 30 parts of salvia miltiorrhiza were extracted twice with 8 times the amount of 80% ethanol under reflux, each time for 2 hours, and filtered to obtain the alcohol extract;

[0056] 44 parts of kudzu root, 30 parts of salvia miltiorrhiza after alcohol extraction, 52 parts of astragalus, 28 parts of codonopsis, 20 parts of radices, 16 parts of Polygonum multiflorum, 16 parts of epimedium, 16 parts of angelica, 16 parts of saponins, 28 parts of seaweed 28 parts of kombu, 28 parts of oysters, 8 parts of citrus aurantium, add 8 times the amount of water together, decoct 2 times, decoct for 2.0 hours respectively, combine the decoction liquid, filter, and the filtrate is concentrated under reduced pressure to a relative density of 1.20 (60 ℃) clear cream; combined with the alcohol extracts of Pueraria root and Salvia miltiorrhiza, add...

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Abstract

The invention discloses a preparation method of sugar-free traditional Chinese medicine oral liquid for treating angina pectoris. In order to overcome the defects of the traditional taste modifying process for preparing the sugar-free oral liquid, the invention adopts the beta-cyclodextrin inclusion technique to modify taste, develops a sugar-free oral liquid specification, realizes the industrialization of the production process of the Chinese medicine oral liquid to which the inclusion technique is applied, improves the taste of the preparation, improves the medicine use compliance of patients, ensures the clinical efficacy of the product, and simultaneously, increases the water-solubility of low-polarity active components by the formation of an inclusion compound, and improves the quality stability of the preparation.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a preparation method of a sugar-free traditional Chinese medicine oral liquid for treating angina pectoris of coronary heart disease. Background technique [0002] Angina pectoris of coronary heart disease is a clinical syndrome caused by temporary myocardial ischemia and hypoxia, with episodic chest pain or chest discomfort as the main manifestation. Angina pectoris often occurs when labor, emotional excitement or other factors increase myocardial oxygen consumption. During the onset of angina pectoris, ECG often shows temporary ST segment changes or accompanied by T wave changes. Coronary angiography shows coronary artery stenosis. [0003] Coronary heart disease is the most common heart disease clinically, with an incidence rate of 3-4%, and its mortality rate accounts for about 20% of cardiovascular disease deaths. With the acceleration of the pace of work and life of the...

Claims

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Application Information

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IPC IPC(8): A61K36/8968A61K9/00A61P9/10A61K35/56A61K35/618
Inventor 赵志全
Owner LUNAN HOPE PHARM CO LTD
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