Unlock instant, AI-driven research and patent intelligence for your innovation.

Chemotactic factor receptor CXCR4 non-peptide antagonist medicaments for radiodiagnosis and treatment

A technology of chemokine receptors and therapeutic drugs, which is applied in the field of drugs for the diagnosis and treatment of CXCR4-related diseases, and can solve problems affecting AMD3100, etc.

Inactive Publication Date: 2010-07-21
GENERAL HOSPITAL OF PLA
View PDF0 Cites 9 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This toxicity affects the clinical application of AMD3100 as a common drug for tumor treatment

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Chemotactic factor receptor CXCR4 non-peptide antagonist medicaments for radiodiagnosis and treatment
  • Chemotactic factor receptor CXCR4 non-peptide antagonist medicaments for radiodiagnosis and treatment
  • Chemotactic factor receptor CXCR4 non-peptide antagonist medicaments for radiodiagnosis and treatment

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0021] Example 1, drug AMD3100 ( 99m Tc), its structural formula is as follows:

[0022]

[0023] Its preparation method: weigh 100 μg of AMD3100 hydrobromide, add 50 μg of SnCl 2 , and then add an appropriate amount of freshly rinsed high technetium ( 99m Tc) salt, heated at 80°C for one minute, separated and purified, can be used as radiodiagnosis (SPECT) and therapeutic drugs.

example 2

[0024] Example 2, drug AMD3100 ( 111 In)

[0025]

[0026] Preparation method: Weigh 100 μg of AMD3100 hydrobromide, add freshly prepared 111 InCl 3 , to adjust the acidity, after heating at 80°C for one minute, it can be used as a drug for radiodiagnostic SPECT.

example 3

[0027] Example 3, Radiopharmaceutical AMD3100 ( 64 Cu)

[0028]

[0029] Preparation method: Weigh 100 μg of AMD3100 hydrobromide, add freshly prepared 64 CuCl 2 , to adjust the acidity, after heating at 80°C for one minute, it can be used as a radiological diagnosis (SPECT) and therapeutic drug.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses chemotactic factor receptor CXCR4 non-peptide antagonist medicaments for radiodiagnosis and treatment, which are prepared by complexing AMD3100 serving as the parent with radioactive metal ions or labeling by using positron nuclides. The medicaments are used for diagnosing and treating CXCR4 related diseases, such as AIDS, malignant tumor, arthritis and stem cell therapy. The medicaments can be used for diagnosing and treating AIDS, malignant tumor, arthritis and stem cell therapy.

Description

technical field [0001] The invention relates to a medicine for diagnosing and treating CXCR4-related diseases, in particular to a medicine for radiodiagnosis and treatment of chemokine receptor CXCR4 non-peptide antagonist. The radioactive compound is suitable for diagnosis and treatment of diseases related to CXCR4, such as diagnosis (SPECT and PET) and treatment of diseases such as AIDS, malignant tumors, arthritis and stem cell therapy. Background technique [0002] At present, tumor receptor imaging agents are divided into: the first class of neuropeptides, including neurosecretory receptors, gastrin-releasing peptides, vasoactive peptides, etc., such as: 111 In / 90 Y-Octreotide, 131 I-MIBG, 68 Ga-VIP, etc. These imaging provide a new and effective method for the diagnosis / treatment of breast cancer, neuroblastoma and other high incidence or high mortality tumors of various pathological types; the second type is sex hormone receptor class, mainly 18 F-estradiol ( 1...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K51/00A61P19/02A61P31/18A61P35/00A61P43/00A61K103/20A61K103/10A61K103/00
Inventor 张锦明田嘉禾沈丽
Owner GENERAL HOSPITAL OF PLA