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Bioactive artificial tooth root capable of slowly releasing rare-earth element cerium

An artificial tooth root, bioactive technology, applied in the direction of dentistry, dental preparations, dental prosthesis, etc., to achieve high bonding strength and promote the effect of deposition growth

Inactive Publication Date: 2012-04-11
NANTONG MINGNUO ELECTRIC TECH CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Technical problem: The purpose of this invention is to address the above-mentioned shortcomings of artificial tooth root materials, and propose an artificial tooth root that has a slow-release function of rare earth element cerium, and can significantly improve the ability of the artificial tooth root surface to induce osteogenesis at the initial stage of implantation and its preparation method

Method used

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  • Bioactive artificial tooth root capable of slowly releasing rare-earth element cerium
  • Bioactive artificial tooth root capable of slowly releasing rare-earth element cerium
  • Bioactive artificial tooth root capable of slowly releasing rare-earth element cerium

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] (1) First choose pure titanium to process the artificial tooth root;

[0028] (2) Hydrothermal treatment of the surface of the artificial tooth root: the artificial tooth root is polished and polished, then ultrasonically cleaned with acetone, 70% alcohol, and distilled water, and the hydrothermal reaction is carried out with a sodium hydroxide aqueous solution with a concentration of 10mol / L, and the working temperature is 120 degrees Celsius. After 6 hours, a sodium titanate bioactive coating with a microporous structure was obtained on the surface of the artificial tooth root, and its SEM photos and XRD spectra are shown in figure 1 and figure 2 .

[0029] (3) Cerium doping treatment by dipping method: the artificial tooth root prepared above covered with microporous sodium titanate bioactive layer was immersed in soluble cerium salt (NH 4 ) 2 Ce(NO 3 ) 6 The rare earth element cerium was doped into the aqueous solution by ion exchange, (NH 4 ) 2 Ce(NO 3 ) ...

Embodiment 2

[0033] (1) First choose Ti6Al4V alloy to process the artificial tooth root;

[0034](2) Hydrothermal treatment of the surface of the artificial tooth root: the artificial tooth root is polished and polished, then ultrasonically cleaned with acetone, 70% alcohol, and distilled water, and the hydrothermal reaction is carried out with a sodium hydroxide aqueous solution with a concentration of 10mol / L, and the working temperature is 120 degrees Celsius. The time is 6 hours.

[0035] (3) Cerium-doped treatment by dipping method: the artificial tooth root prepared above covered with microporous sodium titanate bioactive layer was immersed in soluble cerium salt Ce(NO 3 ) 4 The rare earth element cerium, Ce(NO 3 ) 4 The concentration of the aqueous solution is 0.05mol L -1 , the liquid surface of the solution should be submerged over the artificial tooth root, the soaking time should not be less than 24 hours, and then washed several times with deionized water to eliminate the r...

Embodiment 3

[0039] (1) First choose pure titanium to process the artificial tooth root;

[0040] (2) Hydrothermal treatment of the surface of the artificial tooth root: the artificial tooth root is ground and polished, then ultrasonically cleaned with acetone, 70% alcohol, and distilled water, and the hydrothermal reaction is carried out with a sodium hydroxide aqueous solution with a concentration of 10mol / L, and the working temperature is 150 degrees Celsius. After 72 hours, a sodium titanate bioactive coating with a microporous structure was obtained on the surface of the artificial tooth root.

[0041] (3) Cerium doping treatment by dipping method: the artificial tooth root prepared above covered with microporous sodium titanate bioactive layer was immersed in soluble cerium salt (NH 4 ) 2 Ce(NO 3 ) 6 The rare earth element cerium was doped into the aqueous solution by ion exchange, (NH 4 ) 2 Ce(NO 3 ) 6 The concentration of the aqueous solution is 0.05mol L -1 , the liquid su...

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Abstract

The invention discloses a bioactive artificial tooth root capable of slowly releasing cerium (a rare-earth element), which consists of a pure titanium and titanium alloy artificial tooth root substrate and a cellular sodium titanate bioactive layer loaded with rare-earth element cerium and bone morphogenetic protein (BMP). The sodium titanate bioactive layer with a cellular structure is combined with the surface of the metal substrate, and prepared by the mutual alternate stacking of the sodium titanate cellular structures generated by the hydro-thermal reaction of the surface of the titaniumand titanium alloy substrate and solution of sodium hydroxide, the cerium and the sodium are subjected to cation exchange and then doped into a coating, the BMP is compounded in the cellular structure under the action of a centrifugal force and a capillary. The preparation method thereof comprises the following steps: processing the artificial tooth root by selecting the pure titanium and titanium alloy; obtaining the sodium titanate layer with the cellular structure on the surface of the artificial tooth root by adopting lye hydrothermal synthesis technology; doping the rare-earth element cerium in the cellular sodium titanate layer through solution soaking ion exchange; finally, loading the bone morphogenetic protein in the cerium-doped cellular sodium titanate bioactive layer by adopting centrifugal load technology.

Description

technical field [0001] The invention relates to a biologically active artificial tooth root capable of slow-releasing rare earth element cerium, in particular to a base made of pure titanium or titanium alloy, and a microporous sodium titanate bioactive coating obtained by using lye hydrothermal synthesis technology. The invention relates to an artificial tooth root impregnated with ion exchange and doped with cerium, using centrifugal loading technology to load bone morphogenetic protein and a preparation method thereof, belonging to the technical field of artificial tooth root materials. Background technique [0002] Dental implants are internationally recognized as the first choice for restoration of missing teeth. They are similar to real teeth in terms of function, shape, and use effects, and can be called "artificial teeth." Dental implants are composed of artificial tooth roots and porcelain crowns. Pure titanium and its alloys are widely used in the manufacture of ar...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K6/04A61K6/02
Inventor 储成林饶席浦跃朴
Owner NANTONG MINGNUO ELECTRIC TECH CO LTD
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