Colon delivery tablet by using pectin / corn protein as coating

A technology of corn gluten and pectin, which is applied in drug delivery, pharmaceutical formulations, and medical preparations of non-active ingredients, etc. Accurate medicine, easy to form and make tablets, avoid flammable and explosive effects

Inactive Publication Date: 2010-08-04
XUZHOU HONGKANG TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

5-Fluorouracil (5-Fu) alone or in combination with chemotherapy is currently an effective method against colon and rectal cancer. However, due to the strong stimulation of the gastrointestinal tract and the inability of the drug to reach the cancerous lesion, the drug's tolerance is reduced and the treatment fails. , so the injection method is still used clinically
However, the current research and reports all have defects such as early release of the drug in the stomach or small intestine, complicated preparation process, and difficult industrialization.

Method used

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  • Colon delivery tablet by using pectin / corn protein as coating
  • Colon delivery tablet by using pectin / corn protein as coating
  • Colon delivery tablet by using pectin / corn protein as coating

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Colonic administration tablet coated with zein, pectin and microcrystalline cellulose and its preparation:

[0059]Described tablet core (1000) is made up of the component of following parts by weight (unit: gram):

[0060] 5-fluorouracil 50.0

[0061] Pharmaceutical microcrystalline cellulose 28.7

[0062] Pharmaceutical lactose 14.3

[0063] Medicinal Sodium Carboxymethyl Starch 5.0

[0064] Medicinal Talc 2.0;

[0065] The coating layer (1000 tablets) is made of the following components by weight:

[0066] Corn protein 160

[0067] Pectin 80

[0068] Pharmaceutical microcrystalline cellulose 60.

[0069] The above-mentioned zein refers to gliadin extracted from corn, purchased from Wujiang Baji Pharmaceutical Excipient Factory.

[0070] The preparation method of the above-mentioned colon administration tablet coated with zein, pectin and microcrystalline cellulose:

[0071] Accurately weigh 5-fluorouracil, microcrystalline cellulose, lactose, sodium carboxym...

Embodiment 2

[0073] Colonic administration tablet coated with zein, pectin and microcrystalline cellulose and its preparation:

[0074] Described tablet core (1000) is made up of the component of following parts by weight (unit: gram):

[0075] Curcumin 60.0

[0076] Pharmaceutical microcrystalline cellulose 22.0

[0077] Medicinal lactose 11.0

[0078] Medicinal Sodium Carboxymethyl Starch 6.0

[0079] Medicinal talcum powder 1.0;

[0080] The coating layer (1000 tablets) is made of the following components by weight:

[0081] Corn protein 150

[0082] Pectin 75

[0083] Microcrystalline Cellulose for Medicinal Use 75.

[0084] The above-mentioned zein refers to gliadin extracted from corn, purchased from Wujiang Baji Pharmaceutical Excipient Factory.

[0085] The preparation method of the above-mentioned colon administration tablet coated with zein, pectin and microcrystalline cellulose:

[0086] Precisely weigh curcumin, microcrystalline cellulose, lactose, sodium carboxymethyl...

Embodiment 3

[0088] Colonic administration tablet coated with zein, pectin and microcrystalline cellulose and its preparation:

[0089] Described tablet core (1000) is made up of the component of following parts by weight (unit: gram):

[0090] 5-aminosalicylic acid 55.0

[0091] Pharmaceutical microcrystalline cellulose 26.0

[0092] Medicinal lactose 13.0

[0093] Medicinal Sodium Carboxymethyl Starch 4.0

[0094] Medicinal talcum powder 1.0;

[0095] The coating layer (1000 tablets) is made of the following components by weight:

[0096] Corn protein 170

[0097] Pectin 85

[0098] Pharmaceutical microcrystalline cellulose 45.

[0099] The above-mentioned zein refers to gliadin extracted from corn, purchased from Wujiang Baji Pharmaceutical Excipient Factory.

[0100] The preparation method of the above-mentioned colon administration tablet coated with zein, pectin and microcrystalline cellulose:

[0101] Accurately weigh 5-aminosalicylic acid, microcrystalline cellulose, lacto...

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PUM

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Abstract

The invention discloses a colon delivery tablet by using pectin / corn protein as a coating, which is prepared by a tablet core containing an active drug and a coating layer, wherein the tablet core is prepared by the following components by weight part: 50.0 +/- 20 parts of active drug, 28.0 +/- 10 parts of medicinal microcrystalline cellulose, 14.0 +/- 6 parts of pharmaceutical lactose, 5.0 +/- 2 parts of medicinal sodium carboxymethyl starch and 2.0 +/- 1 parts of medical talc powder, and the coating layer is prepared by the following components by weight part: 160 +/- 40 parts of corn protein, 80 +/- 20 parts of pectin and 60 +/- 15 parts of medicinal microcrystalline cellulose. A colon drug delivery system formed by the colon delivery tablet realizes the purposes of accurate positioning of colon and controlled-release release of drug, and the colon delivery table has simple and convenient preparation process, easy industrialization, and great development and application prospects.

Description

technical field [0001] The invention relates to a colon drug tablet capable of sustained release in the colon, in particular to a colon drug tablet coated with pectin / zein. Background technique [0002] Colonic administration has many advantages and uses. Oral colonic drug delivery preparations are often used to treat local colonic diseases, such as ulcerative colitis, hemorrhagic colitis, Crohn's disease and colon cancer, etc., which can directly release the drug in the lesion area, so that the drug can work more effectively. [0003] Colon cancer and rectal cancer are second only to lung cancer in the incidence of cancer, and the incidence is increasing year by year. Unfortunately, colon cancer is thought to be inherently resistant to many chemotherapy drugs, either alone or in combination. Currently the most effective treatment is surgery, but there is only a 58% survival rate at 5 years after surgery. Therefore, it is urgent to improve the early diagnosis rate and pro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K9/38A61K47/38
Inventor 郭红霞
Owner XUZHOU HONGKANG TECH
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