Colon delivery tablet by using pectin / corn protein as coating

Abstract

The invention discloses a colon delivery tablet by using pectin / corn protein as a coating, which is prepared by a tablet core containing an active drug and a coating layer, wherein the tablet core is prepared by the following components by weight part: 50.0 + / - 20 parts of active drug, 28.0 + / - 10 parts of medicinal microcrystalline cellulose, 14.0 + / - 6 parts of pharmaceutical lactose, 5.0 + / - 2 parts of medicinal sodium carboxymethyl starch and 2.0 + / - 1 parts of medical talc powder, and the coating layer is prepared by the following components by weight part: 160 + / - 40 parts of corn protein, 80 + / - 20 parts of pectin and 60 + / - 15 parts of medicinal microcrystalline cellulose. A colon drug delivery system formed by the colon delivery tablet realizes the purposes of accurate positioning of colon and controlled-release release of drug, and the colon delivery table has simple and convenient preparation process, easy industrialization, and great development and application prospects.

Description

technical field [0001] The invention relates to a colon drug tablet capable of sustained release in the colon, in particular to a colon drug tablet coated with pectin / zein. Background technique [0002] Colonic administration has many advantages and uses. Oral colonic drug delivery preparations are often used to treat local colonic diseases, such as ulcerative colitis, hemorrhagic colitis, Crohn's disease and colon cancer, etc., which can directly release the drug in the lesion area, so that the drug can work more effectively. [0003] Colon cancer and rectal cancer are second only to lung cancer in the incidence of cancer, and the incidence is increasing year by year. Unfortunately, colon cancer is thought to be inherently resistant to many chemotherapy drugs, either alone or in combination. Currently the most effective treatment is surgery, but there is only a 58% survival rate at 5 years after surgery. Therefore, it is urgent to improve the early diagnosis rate and pro...

AI Technical Summary

Problems solved by technology

5-Fluorouracil (5-Fu) alone or in combination with chemotherapy is currently an effective method against colon and rectal cancer. However, due to the strong stimulation of the gastrointestinal tract and the inability of the drug to reach the cancerous lesion, the drug's tolerance is reduced and the treatment fails. , so the injection method is still used clinically

However, the current research and reports all have defects such as early release of the drug in the stomach or small intestine, complicated preparation process, and difficult industrialization.

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