Artificial blood vessel antibacterial material

An antibacterial material, artificial blood vessel technology, applied in medical science, prosthesis, coating, etc., can solve problems such as low water solubility

Inactive Publication Date: 2010-08-11
王深明 +6
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Aiming at the shortcomings of the prior art, the purpose of the present invention is to provide an antibacterial material for artificial blood vessels to solve the problem of low water solubility of the existing materials

Method used

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  • Artificial blood vessel antibacterial material
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Embodiment Construction

[0014] see figure 1 , figure 2 and image 3 , the organic ligand involved in the present invention intends to select heteroatoms containing oxygen, nitrogen, sulfur, etc., a flexible slender base ligand with a salicylaldehyde coordination end group, and a flexible base ligand containing two 8-hydroxyl (mercapto) group coordination end groups. Linear ligands with controllable flexibility and flexible, semi-rigid and rigid benzimidazole-based nitrogen-atom-containing organic ligands. Six series of new organic-silver complexes were obtained through the direct reaction of this series of organic ligands and silver salts. The results show that the L5 series silver complexes have the strongest antibacterial properties, with a molecular weight of 269.25 and a molecular formula of AgNO 3 ·HOC 2 h 5 , refer to the structure diagram image 3 , has good DNA compatibility, and may develop into a new type of antibacterial medical biomaterial with high biological safety. At the same ...

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Abstract

The invention discloses a preparation method of artificial blood vessel antibacterial material, comprising the following steps: selecting an organic ligand, such as benzimidazolyl and the like with a coordination end group; carrying out chemical reaction on the organic ligand and silver salt under the proper reaction condition to generate organic silver coordination compound. The artificial blood vessel antibacterial material of the invention can be a novel antibacterial material for preventing and curing artificial (vessel) material infection, can satisfy artificial blood vessel antibacterial coating modification and has prospective medical clinical care and application value.

Description

technical field [0001] The invention relates to an antibacterial material, in particular to an artificial blood vessel antibacterial material. Background technique [0002] In the past 30 years, the research on monovalent monetary metals and their complexes and their biological activities has attracted great attention. Inorganic series of antibacterial agents use the bactericidal or antibacterial ability of silver, copper, zinc, titanium, mercury, lead and other metals and their ions, and load them on inorganic carriers to make antibacterial agents. Among them, silver ion not only has good antibacterial properties, but also has good washing resistance, and is non-toxic and non-irritating to the human body. Therefore, silver-loaded inorganic antibacterial agents are widely concerned by people. At present, silver ions and their There are many compounds. [0003] Although silver-based antibacterial agents are the most widely used type of inorganic antibacterial agents, due to...

Claims

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Application Information

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IPC IPC(8): C07F1/10A61L27/28A61L27/54
Inventor 王深明胡作军蔡跃鹏董文飞贺薇刘瑞明张德元
Owner 王深明
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