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Gravity mixing bioreactor obliquely rotating along central shaft of culture vessel

A bioreactor and culture bottle technology, which is applied in the field of gravity mixing bioreactors that tilt and rotate along the central axis of the culture container, can solve the problems of easy contamination of microorganisms, heavy labor, and more dirt, and achieve the effect of simple operation

Active Publication Date: 2012-07-04
博晖生物制药股份有限公司
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Problems solved by technology

[0002] Due to the shortcomings of traditional spinner bottle culture cells, such as large labor load, large number of bottles required, easy contamination of microorganisms, high energy consumption and more dirt, microcarrier cell culture technology has attracted increasing attention.
Imported bioreactors are expensive, while domestic bioreactors are cheaper, and the cultivation effect and stability are not guaranteed.

Method used

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  • Gravity mixing bioreactor obliquely rotating along central shaft of culture vessel
  • Gravity mixing bioreactor obliquely rotating along central shaft of culture vessel
  • Gravity mixing bioreactor obliquely rotating along central shaft of culture vessel

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Embodiment Construction

[0014] In order to make the features and advantages of the present invention more comprehensible, the present invention will be further described in detail below in conjunction with the accompanying drawings and specific embodiments.

[0015] figure 1 , figure 2 In order to realize the side view of the two models of this design idea, the crossbeam (4) in the frame (1) is connected with one or more rows, one or more columns parallel to each other and 5 to 80 degrees from the horizontal plane. The columnar transmission shaft group (3) of angle, the active rotation columnar transmission shaft of every column or every row cylindrical culture bottle fixing device (3) is connected by belt or gear (5), and is connected to common via belt or gear (6). The motor (2) is controlled by the control circuit to drive the motor to actively rotate the cylindrical drive shaft to rotate.

[0016] image 3 It is a front view of a horizontally placed columnar culture vessel fixing device. Ther...

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Abstract

The invention discloses a gravity mixing bioreactor obliquely rotating along a central shaft of a culture vessel, which is a bioreactor capable of causing a culture flask with cylindrical body to implement microcarrier cell culture. In a frame playing the role of fixation and support, an electric motor drives a plurality of cylindrical transmission shafts, which are parallel to each other and form an angle from 5 to 80 degrees in relation to horizontal plane, to rotate so as to drive the cylindrical culture flask to rotate. The cylindrical transmission shafts of the reactor are divided into active rotation transmission shafts and passive rotation transmission shafts adjacent thereto, two adjacent transmission shafts and support bases at the bottoms thereof jointly support the cylindrical culture vessel to rotate. Transmission in transmission belt or gear can be achieved between cylindrical active rotation transmission shafts in rows or columns as well as between cylindrical active rotation transmission shafts in rows or columns and the electric motor. The gravity mixing bioreactor can comprise a circuit control part and can be accommodated in a small temperature controller or placed in a temperature control room.

Description

technical field [0001] Microcarrier cell culture is the main method of large-scale cell culture. Conventional bioreactors for microcarrier cell culture are expensive, complex in structure, and require professional operators to use. The bioreactor involved in the present invention is economical and practical, and easy to operate , making microcarrier cell culture as easy as normal cell flask cell culture. Background technique [0002] Due to the disadvantages of traditional spinner bottle culture, such as heavy labor, a large number of bottles required, easy contamination of microorganisms, high energy consumption, and a lot of dirt, microcarrier cell culture technology has attracted increasing attention. Imported bioreactors are expensive, while domestic bioreactors are cheaper, and the cultivation effect and stability are not guaranteed. Contents of the invention [0003] In order to solve the above-mentioned problems, the present invention provides a microcarrier biorea...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12M3/00
Inventor 杨国松纪广辉
Owner 博晖生物制药股份有限公司
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