Medicine for treating slow arrhythmia sick sinus syndromes

A technology for sinoatrial node syndrome and arrhythmia, applied in drug combinations, cardiovascular system diseases, pharmaceutical formulations, etc., can solve problems such as blockage of evil spirits, blockage, and blockage of yang qi stagnation, and achieve great popularization and application. value, improving cardiac function, and improving quality of life

Active Publication Date: 2010-09-08
吉林康乃尔药业有限公司 +1
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  • Abstract
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  • Claims
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AI Technical Summary

Problems solved by technology

Traditional Chinese medicine treatment of bradyarrhythmia mostly determines the application of treatment methods and prescriptions based on the principles of syndrome differentiation, examination of causes and treatment. etc. are commonly used, but at present, most doctors focus on warming yang and nourishing qi in the treatment. When understanding the pathogenesis of this disease, they fail to pay enough attention to chronic illness and physical w

Method used

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  • Medicine for treating slow arrhythmia sick sinus syndromes
  • Medicine for treating slow arrhythmia sick sinus syndromes
  • Medicine for treating slow arrhythmia sick sinus syndromes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1, preparation for the treatment of bradyarrhythmia sick sinus syndrome medicine (Qiangxinfumai granule)

[0038] One, the present embodiment has prepared the medicine of two dosage forms of granule and powder, and the mass ratio of each raw material in each dosage form is as follows respectively:

[0039] 1. Drug I: 4g red ginseng, 2g sunburned aconite, 5g sunburnt licorice, 2g cassia twig, 2g Panax notoginseng, 6g Poria cocos.

[0040] 2. Drug II: 8g red ginseng, 6g sunburned aconite, 9g sunburnt licorice, 6g cassia twig, 6g Tianqi, 10g poria cocos.

[0041] 3. Drug III: 12g red ginseng, 10g sunburned aconite, 13g sunburned licorice, 10g cassia twig, 10g Tianqi, 14g poria cocos.

[0042] 2. The preparation method of the drug

[0043] (1) Preparation method of granules

[0044] Take 352g of red ginseng, 264g of sunburnt aconite, 396g of sunburnt licorice, 264g of cassia twig, 264g of Panax notoginseng, and 440g of poria cocos.

[0045] Grind Panax notogi...

Embodiment 2

[0053] Embodiment 2, detect the effect of medicine of the present invention by basic research

[0054] In this example, the following experiments were carried out on the drug I, drug II, and drug III in the form of granules.

[0055] The data and results were statistically processed by SPSS software. The t-test was used for the comparison of the means of two samples, and the complete random analysis of variance was used for the multi-sample data.

[0056] 1. In vivo animal experiments:

[0057] Adult big-eared white rabbits, first grade, male or female, 12 weeks old, weighing 2.2-3.0kg (purchased from Beijing Fuhao Experimental Animal Breeding Center, license number: SCXK (Beijing) 2005-2009), were randomly divided into 5 groups, 8 in each group, as follows:

[0058] Normal control group: normal saline 10ml / kg, no modeling, silk thread only passed under the root of the right coronary artery and left without ligation;

[0059] Model control group: normal saline 10ml / kg, no a...

Embodiment 3

[0150] Embodiment 3, detect the effect of medicine of the present invention by clinical research

[0151] In this embodiment, the following experiments were carried out on powdered drug I, drug II and drug III respectively.

[0152] In order to evaluate the efficacy and safety of Qiangxin Fumai Mixture in the treatment of bradyarrhythmia sick sinus syndrome (yang deficiency and blood stasis syndrome), a randomized controlled, multi-center clinical research method was adopted.

[0153] After the medicine is decocted as follows, take it: take a pair of medicine, wrap it well, add an appropriate amount of water to soak for 50-60 minutes, boil it with a strong fire (high fire), and then fry it with a slow fire (low fire) for about 30 minutes to filter out the medicine liquid. Take the medicinal liquid and take it warm.

[0154] A total of 171 patients who were diagnosed with sick sinus syndrome (the syndrome of yang deficiency and blood stasis in traditional Chinese medicine) wer...

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Abstract

The invention discloses a medicine for treating slow arrhythmia sick sinus syndromes and a preparation method thereof. The active components of the medicine for treating slow arrhythmia sick sinus syndrome are prepared from the following raw materials in weight proportion: 1 to 90g of red ginseng, 1 to 90g of processed Radix Aconiti Lateralis, 1 to 90g of Radix Glycyrrhizae Preparata, 1 to 90g of cassia twig, 1 to 90g of Panax pseudo-ginseng and 1 to 90g of Poria cocos. The medicine is obviously superior to atropine in the aspect of improving clinical symptoms, can improve the heart functions of patients and improve the quality of life of the patients; the medicine is superior to the atropine in the aspects of increasing the heart rate and therapeutic effect indexes of Holter, electrocardiogram and the like, improving EF and CO values, an electrocardiogram ST segment and the like in the ultrasonic heart function indexes of hearts; obvious adverse effects are not generated in treatment groups in the research process, and the medicine is clinically safe and valid. Therefore, the medicine has huge popularization and application values in the field of treating the slow arrhythmia sick sinus syndromes.

Description

technical field [0001] The invention relates to a medicine for treating bradyarrhythmia sick sinus syndrome and a preparation method thereof. Background technique [0002] Sick sinus syndrome (referred to as sick sinus syndrome, Sick Sinus Sydrome, SSS) belongs to the category of bradyarrhythmia, and is a common and refractory disease in middle-aged and elderly people. All have, average 65-70 years old, with the increase of age, it is on the rise, and the incidence rate is about 0.17% after more than 50 years old. The 1-year survival rate is 85%-92%, the 5-year survival rate is 62%-65%, and the incidence of embolism is 15%, which seriously threatens people's health. The common causes are coronary heart disease, hypertension, myocarditis, cardiomyopathy, etc., and the unexplained cases accounted for 37%. In 1984, China’s health statistics summary reported that the percentage of cardiovascular disease deaths in total deaths in my country rose from 12.1% in 1957 to 43.8%. The...

Claims

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Application Information

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IPC IPC(8): A61K36/714A61P9/06
Inventor 刘如秀刘志明
Owner 吉林康乃尔药业有限公司
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