Medicine for treating slow arrhythmia sick sinus syndromes
A technology for sinoatrial node syndrome and arrhythmia, applied in drug combinations, cardiovascular system diseases, pharmaceutical formulations, etc., can solve problems such as blockage of evil spirits, blockage, and blockage of yang qi stagnation, and achieve great popularization and application. value, improving cardiac function, and improving quality of life
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Embodiment 1
[0037] Embodiment 1, preparation for the treatment of bradyarrhythmia sick sinus syndrome medicine (Qiangxinfumai granule)
[0038] One, the present embodiment has prepared the medicine of two dosage forms of granule and powder, and the mass ratio of each raw material in each dosage form is as follows respectively:
[0039] 1. Drug I: 4g red ginseng, 2g sunburned aconite, 5g sunburnt licorice, 2g cassia twig, 2g Panax notoginseng, 6g Poria cocos.
[0040] 2. Drug II: 8g red ginseng, 6g sunburned aconite, 9g sunburnt licorice, 6g cassia twig, 6g Tianqi, 10g poria cocos.
[0041] 3. Drug III: 12g red ginseng, 10g sunburned aconite, 13g sunburned licorice, 10g cassia twig, 10g Tianqi, 14g poria cocos.
[0042] 2. The preparation method of the drug
[0043] (1) Preparation method of granules
[0044] Take 352g of red ginseng, 264g of sunburnt aconite, 396g of sunburnt licorice, 264g of cassia twig, 264g of Panax notoginseng, and 440g of poria cocos.
[0045] Grind Panax notogi...
Embodiment 2
[0053] Embodiment 2, detect the effect of medicine of the present invention by basic research
[0054] In this example, the following experiments were carried out on the drug I, drug II, and drug III in the form of granules.
[0055] The data and results were statistically processed by SPSS software. The t-test was used for the comparison of the means of two samples, and the complete random analysis of variance was used for the multi-sample data.
[0056] 1. In vivo animal experiments:
[0057] Adult big-eared white rabbits, first grade, male or female, 12 weeks old, weighing 2.2-3.0kg (purchased from Beijing Fuhao Experimental Animal Breeding Center, license number: SCXK (Beijing) 2005-2009), were randomly divided into 5 groups, 8 in each group, as follows:
[0058] Normal control group: normal saline 10ml / kg, no modeling, silk thread only passed under the root of the right coronary artery and left without ligation;
[0059] Model control group: normal saline 10ml / kg, no a...
Embodiment 3
[0150] Embodiment 3, detect the effect of medicine of the present invention by clinical research
[0151] In this embodiment, the following experiments were carried out on powdered drug I, drug II and drug III respectively.
[0152] In order to evaluate the efficacy and safety of Qiangxin Fumai Mixture in the treatment of bradyarrhythmia sick sinus syndrome (yang deficiency and blood stasis syndrome), a randomized controlled, multi-center clinical research method was adopted.
[0153] After the medicine is decocted as follows, take it: take a pair of medicine, wrap it well, add an appropriate amount of water to soak for 50-60 minutes, boil it with a strong fire (high fire), and then fry it with a slow fire (low fire) for about 30 minutes to filter out the medicine liquid. Take the medicinal liquid and take it warm.
[0154] A total of 171 patients who were diagnosed with sick sinus syndrome (the syndrome of yang deficiency and blood stasis in traditional Chinese medicine) wer...
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