38 results about "Sinus Node Diseases" patented technology

The invention relates to a meglumine adenosine cyclophosphate powder injection medicine composition for injection and a preparation method thereof. Specifically, the invention relates to a medicine composition on one hand and the medicine composition comprises adenosine cyclophosphate, meglumine, mannitol and an optional acid-alkali regulator, wherein based on every 10 parts of adenosine cyclophosphate by weight, the medicine composition comprises the following materials in parts by weight: 5.5-6.5 parts of meglumine, 9-15 parts of mannitol and a proper use amount of the acid-alkali regulator; and the use amount of the acid-alkali regulator ensures that when the medicine composition is dissolved and diluted in water to prepare a solution every 1ml of which contains 10mg of adenosine cyclophosphate, the pH value of the solution is 5.5-7.0. The powder injection composition disclosed by the invention can be used for treating cardiac failure, myocarditis, sick sinus syndromes, coronary heart diseases and cardiomyopathy and can also be applied to adjuvant therapy of cardiac arrhythmia; and the meglumine adenosine cyclophosphate powder injection medicine composition for injection disclosed by the invention has good pharmaceutical properties.

A cardiac monitoring device for determining the occurrence of a sick sinus syndrome condition of a patient that includes electrodes to sense a cardiac signal, a sensing module electrically coupled to the electrodes having circuitry positioned therein to receive the sensed cardiac signal, and a processor coupled to the sensing module and configured to determine an RR interval variability during an RR interval variability session in response to the sensed cardiac signal, determine whether a P-wave occurs during the RR interval variability session, determine whether a sick sinus indicator is satisfied in response to a P-wave occurring, increment a sick sinus count in response to the sick sinus indicator being satisfied, determine whether a sick sinus burden is satisfied in response to the sick sinus count being incremented, and determine the occurrence of sick sinus syndrome in response to the sick sinus burden being satisfied.

The invention discloses a traditional Chinese medicine composition for treating bundle branch block and related heart diseases. The traditional Chinese medicine is made by combining Chinese herbal formulas of monkshood, dried radix rehmanniae, polygonum multiflorum, scrophulariae, salviae miltiorrhizae, red peony roots, raw hawthorns, rhizoma chuanxiong, cassia twig, raw fossil fragments, raw oyster shells, earthworms, amomum, rhizoma alismatis, astragalus, ephedra, radix glycyrrhizae, pulp of cornus and the like. The traditional Chinese medicine composition integrates tonifying and dredging and has the effects on promoting blood circulation and removing blood stasis, promoting circulation of qi and blood, enhancing metabolism and repairing important viscera trauma, and promoting metabolism and regeneration of brain cells, liver cells and myocardial cells. Heart system diseases comprise tachycardia, bradycardia, premature beat, atrial fibrillation and flutter, atrioventricular block, branch conduction block, sick sinus syndrome, pre-excitation syndrome, heart failure, carditis, pericarditis, part of neurosis and the like. The tradition Chinese medicine composition has the miracle effect on treating stagnation of the heart-blood, chest obstructions and chest pains and has the good curative effects on repairing rheumatic heart disease cardiac muscle valves and treating congenital heart disease valve defects and cardiac muscle inferior myocardial infarction.

Cell transplantation for constructing biological heart pacemaker is used embryo source dry / ancestral cell and adult mesogalia dry cell as cell sources. The process is carried out by oriented differentiation inducing for heart pacemaker cell by embryo source multifunctional dry cell, bone marrow adhering to obtain primary culture cell, clone culturing to obtain purifying system by diluting, applying paracrine factor endothelin-1 or nervous adjusting protein-1, extracellular matrix laminated adherent protein and fiber connecting protein etc. substrate glue, trans-dyeing pacemaker gene HCN4, andin-vitro inducing embryo source multifunctional dry cell. It is various and non-immunogenicity. It can be used to treat sick sinus syndrome.

The invention discloses a traditional Chinese medicine composition for treating sick sinus syndrome. The traditional Chinese medicine composition is prepared from radix astragali, honey-fried herba ephedrae, radix codonopsis, cornus officinalis, deerhorn glue, psoralea corylifolia, epimedium, tuber of dwarf lilyturf, radix scrophulariae, ligustrum lucidum, wolfberry, ligusticum wallichii, bitter orange, turmeric root tuber, lumbricus, licorice and monkshood. The traditional Chinese medicine composition can be used in clinic treatment of sick sinus syndrome.

The invention discloses a traditional Chinese medicine for treating chronic cardiac insufficiency, sick sinus syndrome, ischemic angina pectoris, coronary heart disease and the like, and a preparation method thereof. When the traditional Chinese medicine disclosed by the invention is used for clinical evidence, for deficiency of the heart and kidney-yin and stagnation of heart meridian by differentiation of symptoms and signs of traditional Chinese medicine, the total effective rate for treating congestive heart failure is 88.89%, the total effective rate for treating sick sinus syndrome is 85%, and the total effective rate for treating coronary heart disease caused angina pectoris is 90%. The traditional Chinese medicine is a multi-target good medicine convenient and easy to use for heart, and has conformance to the integral function of the heart. The invention is characterized in that the traditional Chinese medicine is a new medicine which is triggered by symptoms of disease, has a compliance mode of action, is capable of better adjusting the continuous coupling function of the heart, and is favorable to the comprehensive recovery and reconstruction of the integral function of the heart. The medicament disclosed by the invention has the following characteristics of exciting the pacemaker when the pacemaker is weak, strengthening the cardiac efficiency when the myocardial contractive power is weak, improving microcirculation and promoting tissue reconstruction and function recovery when the coronary flow is small, and the like, and the medicament is suitable for all kinds of heart diseases and favorable to comprehensive and integral function recovery of the heart.

The invention provides an oral medicine for treating the sick sinus syndrome and a preparation method of the oral medicine. The medicine comprises components in parts by mass as follows: 1-3 parts of prepared lateral roots of aconite, 1-3 parts of dried ginger, 1-3 parts of radix glycyrrhizae preparata, 1-3 parts of Chinese angelica, 1-3 parts of red paeony roots, 1-3 parts of szechuan lovage rhizome, 1-3 parts of safflower, 1-3 parts of danshen roots, 1-3 parts of ladybell root, 1-3 parts of astragalus membranaceus, 1-3 parts of epimedium herb and 1-3 parts of manchurian wildginger. The preparation method of the oral medicine comprises steps as follows: high-quality and first-grade prepared lateral roots of aconite, dried ginger, radix glycyrrhizae preparata, Chinese angelica, red paeony roots, szechuan lovage rhizome, safflower, danshen roots, ladybell root, astragalus membranaceus, epimedium herb and manchurian wildginger are purchased in parts by mass and ground to granules for standby; the ground granular medicines are put into a cloth bag, an opening of the cloth bag is tied, then the cloth bag is soaked in cooled boiled water for about half an hour until medicine tissue is fully soaked, then the well soaked medicines and a supernatant liquid for soaking the medicines are put into a medicine decocting machine together, cooled boiled water is added until the water level is 35 mm higher than the medicines, the medicines are decocted twice, the medicines are decocted for 30 minutes for the first time, after a medicine liquid is filtered, then medium-temperature boiled water is added until the water level is 30 mm higher than the medicines, the medicines are decocted for 25 minutes for the second time, and the medicine liquids obtained after two times of decoction are mixed and condensed to form 1200 mm of a 50% traditional Chinese medicine liquid.

A cardiac monitoring device for determining the occurrence of a sick sinus syndrome condition in a patient, the cardiac monitoring device comprising: electrodes for sensing cardiac signals; a sensing module electrically coupled to the electrodes, the sensing module having circuitry positioned therein to receive the sensed cardiac signal; and a processor coupled to the sensing module and configured to: respond to determining RR interval variability during a RR interval variability session from the sensed cardiac signal; determining whether a P wave occurs during the RR interval variability session; determining whether a disease condition is met in response to the occurrence of a P wave. a sinus index; incrementing a sick sinus count in response to meeting the sick sinus index; determining whether a sick sinus burden is met in response to incrementing the sick sinus count; and determining a sick sinus in response to satisfying the sick sinus burden occurrence of the syndrome.

The invention provides a traditional Chinese medicine composition for treating bradyarrhythmia, which comprises the following raw material medicine in weight percentage: 20-40 parts of Chinese ephedra, 2-4 parts of cassia twig, 1-3 parts of magnolia vine fruit, 15-25 parts of aconite root, 10-20 parts of dried rehmannia root, 5-15 parts of astragalus root, 2-6 parts of asarum herb, 10-20 parts of lilyturf root and 4-8 parts of prepared licorice root. The invention also provides an application of the traditional Chinese medicine composition in the treatment of bradyarrhythmia, particularly in the treatment of sick sinus syndrome and atrioventricular block. The clinical test and animal test show that the traditional Chinese medicine composition has high total effective rate of treating the bradyarrhythmia, works better than the isoprenaline, and has the remarkable significance in treatment of sick sinus syndrome and atrioventricular block; meanwhile, the acute toxicity test shows that the traditional Chinese medicine composition is extremely low in toxicity, thereby being easy to be accepted by patients; and additionally, the traditional Chinese medicine composition is less in components of the raw material medicine, rich, easily obtained, low in price, simple in preparation process, and suitable for universal popularization and application.

The invention provides an application of a Chinese medicine composition in preparing medicines for treating sick sinus syndrome. The Chinese medicine composition comprises ginseng, dwarf lilyturf root, Cornus officinalis, radix salvia miltiorrhiza, fried spine date seed, parasitic loranthus, red paeony root, ground beetle, Nardostachyos Root and Rhizome, and other traditional Chinese medicines. Clinical experiments prove that the Chinese medicine composition has substantial clinic curative effect for treating sick sinus syndrome.

The invention relates to a meglumine adenosine cyclophosphate powder injection medicine composition for injection and a preparation method thereof. Specifically, the invention relates to a medicine composition on one hand and the medicine composition comprises adenosine cyclophosphate, meglumine, mannitol and an optional acid-alkali regulator, wherein based on every 10 parts of adenosine cyclophosphate by weight, the medicine composition comprises the following materials in parts by weight: 5.5-6.5 parts of meglumine, 9-15 parts of mannitol and a proper use amount of the acid-alkali regulator; and the use amount of the acid-alkali regulator ensures that when the medicine composition is dissolved and diluted in water to prepare a solution every 1ml of which contains 10mg of adenosine cyclophosphate, the pH value of the solution is 5.5-7.0. The powder injection composition disclosed by the invention can be used for treating cardiac failure, myocarditis, sick sinus syndromes, coronary heart diseases and cardiomyopathy and can also be applied to adjuvant therapy of cardiac arrhythmia; and the meglumine adenosine cyclophosphate powder injection medicine composition for injection disclosed by the invention has good pharmaceutical properties.

The invention discloses a deoxyribonucleic acid (DNA) library for detecting disease-causing genes of ion channel diseases by using a targeted high-flux semiconductor sequencing technology and application thereof. In particular, a primer pond is designed according to 74 disease-causing genes of ion channel diseases, a sample genome DNA is subjected to super-multiple polymerase chain reaction (PCR) amplification, and amplification products are sequenced by using the high-flux semiconductor sequence technology in order to find disease-causing mutation and lay bases on the aspects of genetics and molecular biology for clinical diagnosis.. The DNA library has the characteristics of accuracy, rapidness, flexibility and low cost. Through 74 gene detection areas, various common fatal ion channel diseases such as long QT syndrome, short QT syndrome, Brugada syndrome, catecholaminergic polymorphic ventricular tachycardia, familial atrial fibrillation, sick sinus syndrome and cardiac conduction block can be detected. The DNA library has important significance and a clinical value to diagnosis and identification of the ion channel diseases.