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Absolute ethyl alcohol injection containing docetaxel and application thereof in preparing medicaments for treating tumors under ultrasonic guidance

A kind of technology of docetaxel and absolute ethanol

Inactive Publication Date: 2012-04-18
FUJIAN MEDICAL UNIV UNION HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005]According to the characteristics of dual blood supply of liver tissue, chemotherapy for liver cancer mostly adopts vascular interventional regional chemotherapy, such as hepatic artery infusion, portal vein infusion chemotherapy, etc., but regional perfusion will still have some Some patients may experience systemic adverse reactions when chemotherapy drugs enter the systemic circulation. TACE is not recommended for patients with moderate to severe liver function impairment, and some patients with hypovascular liver cancer have poor therapeutic effects.

Method used

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  • Absolute ethyl alcohol injection containing docetaxel and application thereof in preparing medicaments for treating tumors under ultrasonic guidance
  • Absolute ethyl alcohol injection containing docetaxel and application thereof in preparing medicaments for treating tumors under ultrasonic guidance
  • Absolute ethyl alcohol injection containing docetaxel and application thereof in preparing medicaments for treating tumors under ultrasonic guidance

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Experimental program
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Effect test

Embodiment 1

[0023] Embodiment 1: Preparation of medicated absolute ethanol

[0024] Anhydrous ethanol injection containing docetaxel was prepared by direct dissolution method. Precisely measure 5ml of dehydrated ethanol with a purity of 99.7%, add 10mg of docetaxel raw material with a purity of 99.5%, vortex and oscillate to fully dissolve to obtain dehydrated ethanol containing the drug, remove impurities and eliminate Bacteria, the medicated anhydrous ethanol after sterilization can be directly used for intratumoral injection.

[0025] The purity of the above-mentioned anhydrous ethanol matrix material is 99.7%, and the purity of docetaxel is 99.5%, and the materials are all commercially available products.

Embodiment 2

[0026] Example 2: Ultrasound-guided local injection of drug-containing ethanol in the treatment of transplanted liver cancer with portal vein tumor thrombus in rabbits

[0027] The method of laparotomy and portal vein intubation, the VX2 tumor strain was directly planted in the portal vein of rabbits, and the growth of the tumor thrombus was observed by ultrasound after operation. When the tumor thrombus involved the first branch of the portal vein in about 3 weeks, 40 experimental rabbits with tumor thrombus were selected and randomly selected. They were divided into a model group, an anhydrous ethanol intratumoral injection group, a dopafil (docetaxel injection) intratumoral injection group, and a drug-containing anhydrous ethanol intratumoral injection group, with 10 rats in each group. In the intratumoral injection group, different reagents were injected into the portal vein tumor thrombus under the guidance of ultrasound, so that the drugs could be evenly distributed. Adm...

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Abstract

The invention relates to an absolute ethyl alcohol injection containing docetaxel and application thereof in preparing medicaments for treating tumors under ultrasonic guidance. The absolute ethyl alcohol injection containing docetaxel can locally treat malignant tumors and cancer emboli in blood vessels around the malignant tumors under ultrasonic guidance. The purity of absolute ethyl alcohol is not less than 99.7%, the purity of docetaxel as a crude drug is not less than 99.5%, and the feeding ratio of the absolute ethyl alcohol to the docetaxel is 1ml / 2mg. The preparation method comprisesthe following steps of directly dissolving the docetaxel in the absolute ethyl alcohol and removing bacteria by adopting an organic-phase filter membrane filter of 0.22 mu m. The drug-contained absolute ethyl alcohol of the invention can exert the docetaxel to inhibit the growth of tumors during the chemical ablation of the absolute ethyl alcohol, and the absolute ethyl alcohol injection can havethe effects of reducing the consumption of the absolute ethyl alcohol, relieving the pains of patients and obviously reducing the whole-body toxic or side effect of the docetaxel through locally mesenchymal drug administration under ultrasonic guidance and is a locally mesenchymal treatment method having great clinical application potential.

Description

Technical field: [0001] The invention relates to an injection for locally treating malignant tumors, which is used for combining tumor chemical ablation agents and interstitial chemotherapy drugs, and belongs to the field of drug development for local interventional therapy of tumors. Background technique: [0002] Percutaneous ethanol injection (PEI) is currently one of the recognized methods for local treatment of liver cancer. The penetration of absolute ethanol into tumor tissue can immediately cause rapid dehydration, necrosis and platelet aggregation of tumor cells and their vascular endothelium, resulting in microvascular embolism inside the tumor. , protein coagulation, and then cause cancer tissue ischemia, coagulation necrosis and fibrous tissue formation. Since the coagulation effect of absolute ethanol on tissue is 1:1, it is difficult to inject an equal volume of ethanol for larger tumors, and the drug distribution in the tumor is uneven. In the past, the indic...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/337A61K31/045A61K9/08A61P35/00
Inventor 林礼务薛恩生陈志奎
Owner FUJIAN MEDICAL UNIV UNION HOSPITAL
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