Chinese medicinal compound with function of treating diabetes and preparation method and application thereof

A diabetes and action technology, applied in the field of traditional Chinese medicine compound and its preparation, can solve the problems of lack of clinical efficacy research, treating symptoms but not the root cause, and inconsistent treatment, and achieves the effects of enhancing immune function, high content of active ingredients and lowering blood lipids

Active Publication Date: 2010-09-15
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many drugs for the treatment of diabetes. Although the western medicines used clinically have certain curative effects, most of them have relatively large adverse reactions, such as rebound after drug withdrawal, liver and kidney damage, rhabdomyolysis and other side effects. , and traditional Chinese medicine has its unique advantages in the treatment of diabetes. Traditional Chinese medicine has a long history of preventing and treating diabetes combined with hyperlipidemia. Proven prescriptions, lack of systematic and comprehensive clinical efficacy research, and the basis of traditional Chinese medicine prescriptions are different, and the treatment principles are not uniform. Therefore, based on traditional Chinese medicine, according to the pathogenesis of diabetes, actively search and work hard to explore the treatment of this disease. Efficient, non-toxic, and easy to carry medicine, which is of great significance

Method used

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  • Chinese medicinal compound with function of treating diabetes and preparation method and application thereof
  • Chinese medicinal compound with function of treating diabetes and preparation method and application thereof
  • Chinese medicinal compound with function of treating diabetes and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] 1. Composition of raw materials of traditional Chinese medicine compound:

[0032] 12 grams of Polygonatum, 10 grams of Sunburned Silkworm, 10 grams of Ghost Arrow Feather, 12 grams of Lycium barbarum, and 15 grams of Eupatorium.

[0033] 2. A method for preparing a Chinese medicine compound composition preparation, comprising the following steps:

[0034] (1) Take 10 grams of broiled silkworm, 10 grams of ghost arrow feathers, 12 grams of wolfberry, and 15 grams of Eupatorium, decoct twice with 8 times the amount of water, 1.5 hours for the first time, 1 hour for the second time, and fry together Boil the liquid, filter, concentrate to obtain the concentrated liquid, and set aside;

[0035] (2) get Polygonatum 12 grams, soak 12 hours with the concentration of 55% ethanol, filter out the dregs after the soaking liquid and use 5 times the concentration of 55% ethanol to reflux extract 2 times, each time for 0.5 hour, merge the soaking liquid and extract liquid, concent...

Embodiment 2

[0038] 1. Composition of raw materials of traditional Chinese medicine compound:

[0039] Rhizoma Polygonatum 10 grams, Sunburn Silkworm 8 grams, Ghost Arrow Feather 8 grams, Lycium barbarum 10 grams, Eupatorium 12 grams.

[0040] 2. A method for preparing a Chinese medicine compound composition preparation, comprising the following steps:

[0041] (1) Take 8 grams of sunburned silkworm, 8 grams of ghost arrow feathers, 10 grams of Chinese wolfberry, and 12 grams of eupatorium, decoct twice with 6 times the amount of water for 1.5 hours each time, combine the decoction liquid, filter, concentrate, Get the concentrated solution for later use;

[0042] (2) get Polygonatum 10 grams, soak 16 hours with the concentration of 55% ethanol, filter out the dregs after soaking liquid and then use 8 times the concentration of 55% ethanol to reflux extract 2 times, each time for 1 hour, merge the soaking liquid and extract liquid, concentrated under reduced pressure to obtain a concentra...

Embodiment 3

[0045] 1. Composition of raw materials of traditional Chinese medicine compound:

[0046] 20 grams of Huang Jing, 15 grams of broiled silkworm, 15 grams of ghost arrow feathers, 20 grams of wolfberry, and 20 grams of eupatorium.

[0047] 2. A method for preparing a Chinese medicine compound composition preparation, comprising the following steps:

[0048] (1) Take 15 grams of broiled silkworm, 15 grams of ghost arrow feather, 20 grams of Chinese wolfberry, and 20 grams of Eupatorium, decoct twice with 8 times the amount of water for 1.5 hours each time, combine the decoction liquid, filter, concentrate, Get the concentrated solution for later use;

[0049] (2) get Polygonatum 20 grams, soak 12 hours in 50% ethanol with a concentration, filter out the dregs after soaking liquid and then use 6 times the concentration of 50% ethanol to reflux extract 2 times, each time for 1.5 hours, merge the soaking liquid and extract liquid, concentrated under reduced pressure to obtain a conc...

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Abstract

The invention discloses a Chinese medicinal compound with function of treating diabetes and a preparation method and application thereof. The Chinese medicinal compound consists of the following raw materials in part by weight: 8 to 20 parts of sealwort, 5 to 15 parts of roasted stiff silkworm, 5 to 15 parts of winged euonymus twig, 8 to 20 parts of Chinese wolfberry and 10 to 20 parts of hiraute shiny bugleweed herb. The Chinese medicinal compound provided by the invention is prepared and formulated by adopting the theory of syndrome differentiation and treatment according to the Chinese medicinal theory; experimental results show that the Chinese medicinal compound provided by the invention has multi-link and multi-target combined action, and can correct glucose metabolism turbulence, reduce blood sugar, improve pancreatic B cell function, improve insulin resistance and enhance immunologic function; and the experimental results show that the Chinese medicinal compound provided by the invention can effectively reduce serum total cholesterol, triglyceride, serum free fatty acid and urine micro-albumin, has good effects of resisting lipid peroxidation, improving blood flowage and preventing or delaying atherosclerosis, and can be used for preventing and treating diabetes mellitus associated with hyperlipaemia and cardiovascular diseases.

Description

technical field [0001] The invention relates to a medicine, in particular to a traditional Chinese medicine compound with the function of treating diabetes, its preparation method and its application. Background technique [0002] Diabetes is a common and frequently-occurring disease worldwide, and has become the third largest disease after tumors and cardiovascular diseases. Diabetes combined with hyperlipidemia is one of the most common comorbid diseases. At present, it is clear that lipid metabolism disorder in diabetes is the main risk factor for the incidence of cardiovascular and cerebrovascular complications such as coronary heart disease, hypertension, myocardial infarction and stroke. affect people's quality of life. At present, there are many drugs for the treatment of diabetes. Although the western medicines used clinically have certain curative effects, most of them have relatively large adverse reactions, such as rebound after drug withdrawal, liver and kidney...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8969A61P3/06A61P3/10A61P9/00A61K35/64
Inventor 王旭周仲瑛
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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