Methods for the directed expansion of epitopes for use as antibody ligands

An antibody and epitope technology, which can be used in the preparation methods of peptides, pharmaceutical formulations, antibody medical components, etc., and can solve problems such as logistics and cost obstacles and limitations
CN101848731AInactive Publication Date: 2010-09-29PEPTIMMUNE
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
PEPTIMMUNE
Publication Date
2010-09-29
Estimated Expiration
Not applicable · inactive patent

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Abstract

The instant invention comprises a process for selecting and manufacturing antibodies useful for therapeutic, prophylactic, diagnostic or research purposes using epitope peptide mixtures synthesized by the solid phase synthesis, such process defined by a set of rules regarding the identity and the frequency of occurrence of amino acids that substitute a base or native amino acid of a known epitope. The resulting antibodies are related to but distinct from antibodies that bind to the known epitope.
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Description

[0001] Related patents

[0002] This application claims U.S. Provisional Application 60 / 928,225, filed May 7, 2007, U.S. Provisional Application 60 / 999,283, filed October 16, 2007, U.S. Provisional Application 60 / 999,284, filed October 16, 2007 and priority of US provisional application 61 / 124,689, filed April 17, 2008. This application is also a continuation-in-part of US Application 11 / 787,229, filed April 13, 2007, which claims priority to US Provisional Application 60 / 792,085, filed April 13, 2006. The contents of all applications listed above are incorporated herein by reference in their entirety. Background of the invention

[0003] In recent years, antibodies have solidified their status as an effective class of therapeutic drugs for a variety of diseases and conditions. At present, 21 kinds of antibody-based drugs have been approved in the world, and a large number are in the process of being completed.

[0004] A single antibody may be specific for one antigen, or...

Claims

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