Chiral alpha-(trichloromethyl) amine compound and preparation method thereof

Abstract

The invention discloses a chiral alpha-(trichloromethyl) amine compound and a preparation method thereof. The chiral alpha-(trichloromethyl) amine compound is a potential bioactive molecule synthesis building block and can serve as an important midbody for synthesizing chiral chloric amine compounds, such as 2,2-dichloro aziridine. The preparation method of the invention has moderate technological condition and abundant and cheap raw materials, and the prepared alpha-(trichloromethyl) amine has high optical purity and is convenient to industrially apply. The alpha-(trichloromethyl) amine prepared by the invention can be widely applied in the fields of asymmetric synthesis and medicine research and development. The structural general formula is disclosed in formula (3).

Description

technical field The invention relates to chiral α-(trichloromethyl)amine compounds and a preparation method thereof. Background technique The structural units of α-(trichloromethyl)amine compounds exist in biologically active molecules, see literature: (a) Bringmann, G.; Feineis, D.; God, R.; Maksimenka, K.; Muhlbacher, J.; K. Tetrahedron 2004, 60, 8143; (b) FAHMY, Mohamed, Abdel, Hamid. WO 91 / 12228, 1991.) reports. α-(trichloromethyl)amines are also very useful organic synthons, which can be converted into 2,2-dichloroaziridines (Zaugg, H.E.; Denet, R.W.J.Org.Chem.1971, 36, 1937-1941), α-amino acid (Shinkevich, E.Y.; Novikov, M.S.; Khlebnikov, A.F. Synthesis 2007, 2, 225) and other important organic compounds. Although α-(trichloromethyl)amines have broad application prospects in the field of life sciences, the preparation methods of chiral α-(trichloromethyl)amines are very limited: based on trichloroethyleneimine as a precursor Only two cases of synthesis have ...

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Problems solved by technology

In addition, the literature Dilman, A.D.; Arkhipov, D.E.; Levin, V.V.; Belyakov, P.A.; Korlyukov, A.A.; 3 Preparation of racemic α-(trichloromethyl)amine by addition of salicylaldimine, but based on TMSCCl 3 The preparation of chiral α-(trichloromethyl)amine by addition of chiral imine is still a blank

At present, as the above-mentioned document Miltz, W.; Steglich, W.Synthesis 1990, 9, the preparation method reported in 750 needs to utilize expensive chiral enamine: above-mentioned document Zajac, M.; Peters, R.Org.Lett. The method reported in 2007, September, 2007 has the problem that the raw material sultone is not easy to prepare and the optical purity is not high

In addition, the above-mentioned preparation methods all have universal defects and cannot meet the needs of the development of related fields.

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