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Technology for extracting and preparing policosanol

A preparation process, the technology of pliol, which is applied in the preparation of organic compounds, preparation of oxygenated compounds, separation/purification of hydroxyl compounds, etc., can solve the problems of low pletilol content and insignificant pharmacological functions, and improve the product quality. The effect of purity

Inactive Publication Date: 2012-09-26
ZHONGSHAN BAILING BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] There are several problems in these processes. First, it is only suitable for extracting pliol from sucrose wax with high octacosanol content; second, the extracted pliol content is low, so the pharmacological function is not significant

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Take 50 grams of domestic sucrose wax, add 500 milliliters of methanol and 10 grams of sodium hydroxide, heat up to a reflux state, and maintain the reflux state for 18 hours. Vacuum distillation to remove methanol, add 150 ml of petroleum ether and 300 ml of water, stir thoroughly for 30 minutes, let stand to separate layers, discard the water phase, wash twice with 300 ml of water, and take the petroleum ether phase. The temperature was lowered to 0°C, crystals were precipitated, filtered, and dried to obtain 10.3 g of crude product. Add 10.3 g of the crude product to a reaction flask containing 200 ml of butyl acetate, raise the temperature to 80° C. and stir to dissolve, add 1 g of activated carbon, stir for 30 minutes to decolorize, and filter to obtain the filtrate. The charcoal cake was washed with 10 ml of butyl acetate. Combine the filtrate and washings, lower the temperature to 5°C and maintain for 1 hour, filter, wash with 20 ml of frozen butyl acetate, and ...

Embodiment 2

[0030] Take 50 grams of domestic cane wax, add 750 milliliters of 95% ethanol and 20 grams of sodium hydroxide, heat up to a reflux state, and maintain the reflux state for 12 hours. Ethanol was removed by vacuum distillation, 200 ml of methyl isobutyl ketone and 300 ml of water were added, fully stirred for 30 minutes, the layers were left to stand, the water phase was discarded, and washed twice with 300 ml of water to obtain the methyl isobutyl phase. The temperature was lowered to 0°C, crystals were precipitated, filtered, and dried to obtain 9.7 g of crude product. Add 9.7 g of the crude product into a reaction flask containing 300 ml of methanol, raise the temperature to reflux and stir to dissolve, add 1 g of activated carbon, stir for 30 minutes to decolorize, and filter to obtain the filtrate. The charcoal cake was washed with 10 ml of methanol. The filtrate and washings were combined, distilled to half the volume, cooled to 0°C and kept stirring for 1 hour, filtered...

Embodiment 3

[0032] Take 50 grams of domestic cane wax, add 750 milliliters of isobutanol and 10 grams of potassium hydroxide, heat up to a reflux state, and maintain the reflux state for 18 hours. Add 300 ml of water, stir thoroughly for 30 minutes, let stand to separate layers, discard the water phase, wash twice with 300 ml of water, and take the isobutanol phase. Half of the isobutanol was removed by vacuum distillation (a certain amount of water was azeotropically distilled out), the temperature was lowered to 0° C. and maintained for 1 hour, crystals were precipitated, filtered, and dried to obtain 9.3 g of crude product. In a reaction flask, add 200 ml of methanol and 100 ml of ethyl acetate, stir evenly, add 9.3 g of the crude product from the previous step, heat up to 60°C, stir to dissolve, add 0.5 g of activated carbon, stir for 30 minutes to decolorize, and filter to obtain the filtrate . The charcoal cake was washed with 10 ml of methanol. Combine the filtrate and washings, ...

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Abstract

The invention discloses technology for extracting and preparing policosanol, which comprises the following steps of: a, taking cane wax, adding lower alcohol in an amount of 2 to 40 times that of the cane wax and solid caustic soda in an amount of 0.1 to 1 time that of the cane wax, and performing reflux saponification for 4 to 24 hours under normal pressure; b, removing a solvent through distillation, adding an organic solvent to dissolve the saponified matter, repeatedly washing until the water layer is neutral, taking an organic phase, distilling to remove a part of the solvent, reducing the temperature for crystallization, and filtering and drying so as to obtain an octacosanol-containing coarse product; c, dissolving the coarse product by using a solvent in an amount of 5 to 100 times that of the coarse product, adding active carbon in an amount of 0.01 to 1 time, stirring to decolor for 5 minutes to 2 hours, filtering to remove the partial solvent through vacuum distillation, reducing the temperature for crystallization, and filtering and drying so as to obtain a product, wherein the content of the octacosanol is 30 to 75 percent, and the content of the total alcohol is 70 to 90 percent; and d, after dissolving the product, performing column chromatography absorption, eluting by using hydrocarbon, alcohol, ketone and ester solvents or mixture thereof, collecting corresponding distilled substances, performing vacuum concentration, reducing the temperature for crystallization, and filtering and drying so as to obtain the policosanol, wherein the content of the octacosanol is over 90 percent, and the content of the total alcohol is over 95 percent.

Description

technical field [0001] The invention relates to a process for extracting and preparing pliol. Background technique [0002] Polyol is a series of natural high-carbon fatty alcohols including C24, C26, C27, C28, and C30. It is mainly found in natural products such as cane wax, rice bran wax, beeswax, wheat germ oil, and wormwood. Among them, octacosanol has a strong pharmacological activity to promote physiological functions, and has been found to have the following functions after research: (1) enhance energy, endurance and physical strength; (2) strengthen heart function and prevent cardiovascular diseases; (3) improve 4) Improve the adaptability of the human body environment; it can be used to prevent and treat syndrome X, complications of atherosclerosis, gastric ulcer, improve sexual performance, and improve local ischemia. It is an ideal natural health food additive with broad market development prospects. [0003] The main component of sucrose wax is esters (accounti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C31/02C07C29/76C07C29/78C07C27/02
Inventor 张和平
Owner ZHONGSHAN BAILING BIOTECHNOLOGY CO LTD
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