Traditional Chinese medicine composite with function of inhibiting alpha-glucuroide and xanthine oxidase and preparation method and applications thereof

A technology of xanthine oxidase and glucosidase, which is applied in the direction of drug combination, pharmaceutical formula, medical preparation containing active ingredients, etc.

Inactive Publication Date: 2010-11-10
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Drynaria and its composition are used to simultaneously screen the two enzyme inhibitors, but there is no report

Method used

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  • Traditional Chinese medicine composite with function of inhibiting alpha-glucuroide and xanthine oxidase and preparation method and applications thereof
  • Traditional Chinese medicine composite with function of inhibiting alpha-glucuroide and xanthine oxidase and preparation method and applications thereof
  • Traditional Chinese medicine composite with function of inhibiting alpha-glucuroide and xanthine oxidase and preparation method and applications thereof

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Experimental program
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Effect test

Embodiment 1

[0067] In conjunction with specific embodiments, the present invention is further described as follows:

[0068] Proportion of raw materials: drynaria rhizome 1 mass part, night jelly 1 mass part

[0069] In the present invention, Drynaria fortunei is the rhizome of Drynaria fortunei (Kunze) J.Sm, a perennial epiphytic fern of the family Aquaphyceae. Bitter in the mouth, warm in nature. Return kidney, Liver Channel. It has the effects of invigorating the kidney and supporting yang, strengthening bones, relieving injuries and relieving pain, warming the spleen and stopping diarrhea. Rhizoma drynaria has the functions of the above two enzyme inhibitors in this prescription. By nourishing the kidney and warming the spleen, it can regulate the spleen to transport water and grain, transform qi and blood, reduce postprandial hyperglycemia and hyperuricemia, and treat impaired glucose tolerance and diabetes. , obesity, hyperuricemia, and complications such as osteoporosis play an ...

Embodiment 2

[0076](1) Preparation of water extract of Rhizoma Drynariae: Add 20 times distilled water to Rhizoma Rhizoma Rhizoma Rhizoma Drynariae, soak in cold at room temperature for 2 hours, decoct in water for 1 hour, filter, add distilled water and repeat decoction once; combine twice The filtrate was cooled to room temperature and then centrifuged at 3000rpm / min for 10min. The supernatant part was concentrated on a boiling water bath. After heating and concentrating, the distilled water was adjusted to 0.5g crude drug / mL.

[0077] (2) Preparation of Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Extract: Prepare the water extract according to the above method, add ethanol to the water extract concentrate to reach a concentration of 50vt%, mix well, centrifuge at 3000rpm / min for 10min in a refrigerator at 4°C overnight, and take the supernatant The liquid part was concentrated on a boiling water bath, and distilled water was added to make up to volume.

[0078] (3) Preparation of Rh...

Embodiment 3

[0080] (1) Preparation of the water extract compatible with Rhizoma Rhizoma Drynariae and Caulis Rhizoma: add 15 times the weight of distilled water to the medicinal materials that are compatible with Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizoma Rhizome at 0.5:1 weight ratio, cold soak at room temperature for 1 hour, Decoct in water for 1 hour, filter, add distilled water and repeat the decoction once; combine the filtrates twice, cool to room temperature, centrifuge at 3000rpm / min for 10min, concentrate part of the supernatant on a boiling water bath, heat and concentrate to 0.5g with distilled water Crude drug / mL.

[0081] (2) Preparation of drynaria rhizoma drynariae and Caulis Nocturia compatible extract: prepare the water extract according to the above method, add ethanol concentration to the water extract concentrate to reach 45vt%, mix well, centrifuge at 3000rpm / min after overnight in 4°C refrigerator , 10min, take the supernatant part of the boiling water bath to c...

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Abstract

The invention discloses a traditional Chinese medicine composite with a function of inhibiting alpha-glucuroide and xanthine oxidase and a preparation method and applications thereof. The bulk pharmaceutical chemical of the traditional Chinese medicine composite comprises drynaria rhizome, and also can comprise tuber fleeceflower stem, wherein, the weight ratio of drynaria rhizome to tuber fleeceflower stem is (0.5-2): 1, the preferential weight ratio is 1:1. The traditional Chinese medicine composite is based on two enzyme inhibitors of alpha-glucuroide and xanthine oxidase, and has double functions of reducing postprandial plasma glucose and blood uric acid. The invention has rich resource and low price, is safe and non-toxic, and has consistent function with Glucobay and allopurinol, thus the invention can be used for treating the diseases of glucose tolerance defect, diabetes, obesity, hyperuricemia and gout and the like.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a medicine capable of inhibiting alpha-glucosidase and xanthine oxidase, a preparation method and application thereof. Background technique [0002] Postprandial hyperglycemia is a clinical feature of impaired glucose tolerance (IGT), a common symptom of type 1 and type 2 diabetes, and is associated with IGT and diabetic complications [1.A Ceriello and S Colagiuri International Diabetes Federation guideline for management of postmeal glucose: a review of recommendations [J]. Diabet Med, 2008, 25(10): 151-11156.]. Timely control of postprandial hyperglycemia in the IGT phase can restore blood sugar to normal in 1 / 3 of the high-risk population and reduce the occurrence of diabetes and its complications in 1 / 3 of the high-risk population. [0003] For this reason, at the 43rd EASD Annual Meeting in 2007, IDF released the "Guidelines for Postprandia...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/11A61K36/704A61P3/10A61P3/04A61P19/06A61K125/00
Inventor 吴慧平席昱陈美娟许婷婷严令耕陈建伟张喆席蓓莉赵凤鸣哈团柱
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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