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Medical application of caulis polygoni multiflori

A technology of nocturnal vines and drugs, which is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, and drug combinations.

Inactive Publication Date: 2012-10-24
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report on the simultaneous screening of these two enzyme inhibitors with the compound composition of Nocturna and Sargentina

Method used

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  • Medical application of caulis polygoni multiflori
  • Medical application of caulis polygoni multiflori
  • Medical application of caulis polygoni multiflori

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1: Preparation of the water extract or extract or polysaccharide of Caulis japonica.

[0026] Preparation of the water extract of the vine: Take 50g of the decoction pieces of the vine, add 20 times the weight of distilled water, soak at room temperature for 2 hours, decoct in water for 1 hour, filter, add distilled water and repeat the decoction once; combine the filtrates twice, cool After reaching room temperature, centrifuge at 3000rpm / min for 10min, concentrate the supernatant part on a boiling water bath, add distilled water to make it 0.5g crude drug / mL.

[0027] Preparation of Caulis japonica extract: Prepare the water extract according to the above method for preparing the water extract of Caulis japonica, add ethanol to reach a concentration of 50vt%, mix well, centrifuge at 3000rpm / min for 10min in a refrigerator at 4°C overnight, take the supernatant and concentrate , add distilled water to make up to 0.5g crude drug / mL.

[0028] The preparation of ...

Embodiment 2

[0029] Embodiment 2: the preparation of the aqueous extract or extract or polysaccharide of S.

[0030]Preparation of the water extract of S. sanctana: take 50g of decoction slices of S. tulana, add 20 times the weight of distilled water, soak at room temperature for 2 hours, decoct in water for 1 hour, filter, add distilled water and repeat the decoction once; combine the filtrates twice, and cool After reaching room temperature, centrifuge at 3000rpm / min for 10min, concentrate the supernatant part on a boiling water bath, add distilled water to make it 0.5g crude drug / mL.

[0031] Preparation of S. sanctana extract: Prepare the water extract according to the preparation method of the above-mentioned S. sanctana water extract, add ethanol to reach a concentration of 50vt%, mix well, centrifuge at 3000rpm / min for 10min in a refrigerator at 4°C overnight, and take the supernatant to concentrate , add distilled water to make up to 0.5g crude drug / mL.

[0032] The preparation of...

Embodiment 3

[0033] Example 3: Preparation of aqueous extracts or extracts or polysaccharides of Caulis japonica and Caulis Sargentina compatible.

[0034] Preparation of the compatible water extract of Caulis radix and Caulis Sinensis: Take 50g decoction pieces of Caulis syringae and 50g decoction pieces of Caulis Sargentina, add 20 times the weight of distilled water, soak at room temperature for 2 hours, decoct in water for 1 hour, filter, and then add distilled water Repeat the decoction once; combine the two filtrates, cool to room temperature and centrifuge at 3000rpm / min for 10min, concentrate the supernatant on a boiling water bath, add distilled water to make up to 0.5g crude drug / mL.

[0035] Preparation of the compatible extract of Caulis radix and Caulis Sargentina: prepare the water extract according to the above-mentioned preparation method for the compatible water extract of Caulis radix and Caulis Sargentina, add ethanol to a concentration of 50vt%, mix well, and centrifuge ...

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Abstract

The invention discloses application of caulis polygoni multiflori aqueous extracts or extracting paste or amylase to the preparation of medicine for treating glucose tolerance lack, diabetes, adiposity, hyperuricemia or uarthritis. The invention also discloses the application of aqueous extracts or extracting paste prepared from caulis polygoni multiflori and sargentg loryvine according to a weight ratio of 1 / 1 to the preparation of medicine for treating glucose tolerance lack, diabetes, adiposity, hyperuricemia or uarthritis. The invention is obtained through sieving from 70 kinds of traditional Chinese medicine and 16 kinds of compositions which do not have the hyperglycemic, blood uric acid reduction, alpha-glucosaccharase inhabiting agents and xanthine oxidase inhabiting agents till now, and consists of the caulis polygoni multiflori or the caulis polygoni multiflori and the sargentg loryvine. The invention discovers the inhabiting effects on the alpha-glucosaccharase and the xanthine oxidase for the first time.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to the new medical application of the vine of night jelly. Background technique [0002] Postprandial hyperglycemia is a clinical feature of impaired glucose tolerance (IGT), a common symptom of type 1 and type 2 diabetes, and is associated with IGT and diabetic complications [A Ceriello and S Colagiuri International Diabetes Federation guideline for management of postmeal glucose: a review of recommendations [J]. Diabet Med, 2008, 25(10): 151-11156.]. Timely control of postprandial hyperglycemia in the IGT phase can restore blood sugar to normal in 1 / 3 of the high-risk population and reduce the occurrence of diabetes and its complications in 1 / 3 of the high-risk population. [0003] For this reason, at the 43rd EASD Annual Meeting in 2007, IDF released the "Guidelines for Postprandial Blood Glucose Management" and listed α-glucosidase inhibitors (...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/704A61P3/04A61P3/10A61P19/06
Inventor 吴慧平哈团柱张喆席昱陈建伟倪荷芳戴晓明詹瑧张旭瞿融郜明江亚兵
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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