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Device for simulating the stomach of a monogastric mammal or of a human being

A mammal and simulation device technology, applied in the field of simulation devices, can solve problems such as inconvenient management and control of substances

Inactive Publication Date: 2012-03-14
UNIV DAUVERGNE CLERMONT FERRAND 1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] Finally, the instruments described in WO-A-94 / 09895 and WO-A-2007 / 010238 do not allow convenient management and control of the input and / or output of substances, such as the substances to be tested, at a defined moment in the digestion simulation

Method used

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  • Device for simulating the stomach of a monogastric mammal or of a human being
  • Device for simulating the stomach of a monogastric mammal or of a human being
  • Device for simulating the stomach of a monogastric mammal or of a human being

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Experimental program
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Embodiment Construction

[0037] figure 1 , 2 , 3, 7 and 8 the device 1 shown comprises two compression chambers C 2 、C 3 . These chambers are delimited by tubular casings 2 and 3 of cylindrical cross-section and are advantageously made, at least in part, of a chemically and biologically neutral and easily sterilizable transparent material, such as glass or polymethacrylic acid ester. This transparent material makes it possible to observe the chamber C 2 and C 3 content.

[0038] The sleeves 2 and 3 are inserted into correspondingly shaped holes provided on the square plates 4a, 4b, 4c, 4d. exist Figure 7 In the embodiment shown, some rods 5 connect the corners of the plate 4 with an intermediate unit 8, the main unit, which has the general shape of a cube and defines an intermediate chamber C 8 , called the main chamber. The plates 4 a to 4 d and the rod 5 thus form a supporting and protective frame for the bushings 2 , 3 .

[0039] At each end 40, 41 of the bracket, the end plates 4a, 4d ...

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Abstract

The invention relates to a device for simulating the stomach of a monogastric mammal or of a human being that includes at least two compression chambers (C2, C3) connected together by an intermediate chamber. Each compression chamber (C2, C3) includes a piston (72, 73) adapted for urging the content of a compression chamber (C2, C3) towards the other compression chamber (C2, C3). The device includes means (20) capable of generating turbulent flow of the device content when passing through the intermediate chamber (C8). The intermediate chamber (C8) is formed in an intermediate block (8) provided with an access means (11a, 12, 16) for supplying products (12) and / or tapping the content of the device at any moment of the operation cycle thereof.

Description

technical field [0001] The present invention relates to a device for simulating the stomach of a monogastric mammal or human. Background technique [0002] This device allows in vitro studies of the digestion of food, and the properties of certain substances that are eaten or can be eaten, such as food supplements, xenobiotics, pathogens or pharmaceuticals. Studies with the aid of this device evaluate the effect of the gastric environment on these substances, such as the time required for the solid components to degrade into particles fine enough to continue their journey in the intestinal tract, the release kinetics of the active ingredient, the The interaction between various substances in the internal environment, and / or the survival of microorganisms. [0003] In order to reflect the gastric environment, such a device must have certain features and perform multiple functions. The device must have an effective volume suitable to ensure effective simulation of digestive ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G09B23/32G09B23/36
CPCG09B23/36G09B23/32
Inventor M·阿尔里克S·G·J·德尼
Owner UNIV DAUVERGNE CLERMONT FERRAND 1