Electric hydrogel sticking agent for instantaneous pulse electric field transdermal drug administration and preparation method thereof
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A conductive hydrogel, transdermal drug delivery technology, applied in the direction of conductive adhesives, electrotherapy, adhesives, etc., can solve the problems of low added value of drugs, weak market competitiveness, poor economic benefits, etc., to solve the inconvenience of medication , Promote transdermal absorption, large drug loading effect
Inactive Publication Date: 2010-12-29
NORTHWEST UNIV
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Problems solved by technology
One of the main reasons is that the low level of preparations leads to low added value of drugs, weak market competitiveness and poor economic benefits
Method used
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Effect test
Embodiment 1
[0026] Embodiment 1: Preparation of traditional Chinese medicine conductive hydrogel patch
[0027] ① Weigh 3.4g Viscomate NP-700, 1.6g NP-800, 0.08g EDTA, 0.28g aluminum glycolate, 3g kaolin, 5.5g PVP-k900, 0.15g silver nitrate, mix them well, then add to 40g glycerin , stir evenly to obtain the glycerol phase (phase A).
[0028] ②Weigh 0.28g of tartaric acid, add it into 31g of water, stir evenly to obtain the water phase (phase B).
[0029] ③ Slowly add phase B to phase A one by one, and stir slowly at low speed for 10 minutes to obtain a viscous paste.
[0030] ④ Weigh 15g of Sophora flavescens or Gentiana chinensis paste-like traditional Chinese medicine extract and add it to the paste in ③, then slowly stir and knead at a low speed for 5 minutes to obtain a spare paste.
[0031] ⑤ Then spread the spare paste evenly on the medical non-woven fabric with a thickness of about 1.0mm, covering the isolation layer; cut it into a patch of a certain size, and place it for 24 ho...
Embodiment 2
[0032] Embodiment 2: transdermal drug delivery under the action of transient pulse electric field
[0033] ① Connect the Chinese medicine conductive hydrogel patch to the positive and negative electrodes of the electric pulse instrument respectively, and apply it on the skin at intervals.
[0034] ②The electric pulse condition is pulse voltage 80V, pulse time 1.0ms, waveform is sine wave, pulse frequency 100 / min, and lasts for 1 minute in total.
[0035] Conclusion: The transdermal drug delivery method under the action of transient pulse electric field overcomes the barrier of the stratum corneum of the skin and promotes the transdermal absorption of the drug, and improves the transdermal absorption effect of the drug.
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Abstract
The invention discloses an electric hydrogel sticking agent for instantaneous pulse electric field transdermal drug administration and a preparation method thereof. The preparation method comprises the following steps of: weighing and evenly mixing NP-700, NP-800, PVP-k90, silver ion, EDTA, dihydroxyaluminium aminoacetate and kaolin, adding the mixture into glycerol with the prescription quantity, evenly stirring to obtain glycerol phase, weighing the tartaric acid with the prescription quantity, dissolving in the water to obtain water phase, adding the water phase into the glycerol phase, adding the Chinese traditional medicine extractive with the prescription quantity, stirring to obtain the grease of the Chinese traditional medicine electric hydrogel sticking agent, and coating the grease on a medical non-woven fabric, cutting, statically crosslinking and packing. The electric hydrogel sticking agent has the characteristics of large medicine loading rate, good electric performance, no stimulation, no anaphylaxis and comfortable application, can promote the transdermal absorption of multi-components of the Chinese traditional medicine by combining with the instantaneous pulse electric field, and solves the problem of the inconvenience of the drug administration of the patient who can not continuously administrate the drug caused by the gastrointestinal tract adverse reaction and the damage to the liver and kidneys of the long-term oral medicine.
Description
technical field [0001] The invention relates to a conductive hydrogel patch and a preparation method thereof, in particular to a conductive hydrogel patch for transdermal drug delivery in an instantaneous pulse electric field and a preparation method thereof, belonging to the field of transdermal drug delivery preparations. Background technique [0002] China's pharmaceutical industry has a huge number of products, but its output value is only equivalent to that of a multinational pharmaceutical company. One of the main reasons is that the low level of preparations leads to low added value of drugs, weak market competitiveness and poor economic benefits. In the international market, the price ratio of preparations and raw materials is about 10:1, and in the domestic market is about 3:1. The modernization of preparations has become the core of the modernization of national traditional Chinese medicine. The development of new traditional Chinese medicine drug delivery system ...
Claims
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