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Tulathromycin composition and use thereof in preparation of drugs for treating or preventing bacterial diseases of poultry

A technology of teramycin and composition, applied in the field of veterinary medicine, can solve the problems that do not involve the application of azacyclic macrolide antibiotic composition, etc., and achieve the effects of large apparent distribution volume, small dosage and wide distribution

Inactive Publication Date: 2011-01-05
LUOYANG HUIZHONG ANIMAL MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Patent ZL 01808630.6 discloses the application of azacyclic macrolide antibiotic composition in the treatment or prevention of mammalian bacterial or protozoan infection, but does not involve the application of azacyclic macrolide antibiotic composition in poultry

Method used

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  • Tulathromycin composition and use thereof in preparation of drugs for treating or preventing bacterial diseases of poultry
  • Tulathromycin composition and use thereof in preparation of drugs for treating or preventing bacterial diseases of poultry
  • Tulathromycin composition and use thereof in preparation of drugs for treating or preventing bacterial diseases of poultry

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Example 1 The Sensitivity Measurement of Clinical Isolated Bacterial Strains to Tyramycin

[0052] Detection of bacterial strain resistance: This operation is based on the U.S. NCCLS antimicrobial susceptibility test implementation standard, the diameter of the inhibition zone and the minimum inhibitory concentration (MIC) breakpoint value of the Enterobacteriaceae, which is the breakpoint value of the telamycin composition. Sensitivity criteria.

[0053] Test conditions: medium: Mueller-Hinton inoculum: pick up a single colony and inoculate it in broth, equivalent to 0.5 McFarland standard; incubation: 35°C±2°C; air: 16-18h;

[0054] Strains: isolated from the organs of clinically ill poultry;

[0055] Preparation of standard discs: ① Select Xinhua No. 1 medium-speed qualitative filter paper; use a puncher to punch discs with a diameter of 6 mm, and dry heat sterilization at 160 °C for 2 hours; ② Preparation of drug-containing discs: according to the US NCCLS The dru...

Embodiment 2

[0067] Example 2 Application of 5% W / W Tyramycin Composition in the Preparation of a Pharmaceutical Composition for the Treatment of Avian Bacterial Diseases

[0068] 1. The preparation of the soluble powder pharmaceutical composition of tyramycin (the same below) 5%W / W tyramycin composition

[0069] a. 5% W / W Tyramycin Phosphate (90% Phosphate of Formula I Compound and 10% Phosphate of Formula II Compound)

[0070]

[0071] b. Carrier: glucose powder to 1000g

[0072] Preparation steps: Take 68.36 g of telamycin phosphate and glucose powder, mix evenly, pulverize, and pass through an 80-mesh sieve to obtain a pharmaceutical composition of telamycin composition.

[0073] Pharmacokinetic Study of 2.5% W / W Tyramycin Soluble Powder on Chicken

[0074] After dissolving the soluble telamycin powder in purified water, give the chicken 10mg / kg body weight orally orally. 5, 10, 15, 30 min, 1, 2, 4, 8, 12 h, and 1, 2, 4, 6, 8, 10, 12, 15 d after administration, collect 1.5 mL of ...

Embodiment 3

[0089] Example 3 Application of 2% W / W Tyramycin Composition in the Preparation of Granular Pharmaceutical Composition for the Treatment of Avian Bacterial Diseases

[0090] 1. The preparation of the pharmaceutical composition of 2%W / W Tyramycin composition in terms of Tyramycin (the same below)

[0091] a. 2% W / W Tyramycin tartrate (90% tartrate of the compound of formula I and 10% tartrate of the compound of formula II) in terms of Tyramycin;

[0092] b. Carrier: dextrin 200g, sucrose up to 1000g.

[0093] Preparation steps: take sucrose, pulverize, mix with 31.17 g of telamycin tartrate and dextrin, granulate, and dry to obtain the pharmaceutical composition of telamycin composition.

[0094] 2. Therapeutic effect of oral different doses of 2% W / W Tyramycin composition on pullorum

[0095] Model preparation method: Inoculate drug-resistant Salmonella GXS0014 (clinical isolation) on MH agar plate and incubate at 37°C for 24 hours, pick a single colony and inoculate it in M...

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Abstract

The invention discloses an application of a tulathromycin composition in treatment or prevention of bacterial diseases of poultry. The invention further discloses a pharmaceutical composition containing tulathromycin and a preparation method thereof, and the composition has wide distribution in a poultry body, large apparent distribution volume, long half-life period and slow elimination, has the characteristics of small dosage and good efficacy when being used for treating the bacterial diseases of the poultry, and further has broad market prospects and value when being applied in the preparation of the drugs which are widely clinically used in veterinary.

Description

technical field [0001] The invention relates to the use of a telamycin composition in treating or preventing poultry bacterial diseases, and belongs to the field of veterinary medicine. Background technique [0002] Bacterial disease is the most important disease that harms all animals in our country. Bacterial diseases in poultry seriously endanger the aquaculture industry, which can cause animal feed remuneration to decrease, growth stagnation or even death, and cause serious economic losses to the aquaculture industry. Antibiotics are the most commonly used drugs against bacterial infections. Due to the abuse of antibiotics in China, drug-resistant strains are gradually increasing, and the efficacy of many antibacterial drugs is declining. In addition to the gradual standardization of the domestic veterinary drug industry, there are few good antibacterial drugs in China. Therefore, the majority of clinical veterinary workers urgently need good antibacterial drugs for ani...

Claims

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Application Information

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IPC IPC(8): A61K31/7052A61P31/04
Inventor 张许科刘兴金张晓会
Owner LUOYANG HUIZHONG ANIMAL MEDICINE
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